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Total cholesterol: every measured intervention

Ranked only against the same measurement, in the same unit. See the positive, neutral, opposite-direction and still-collecting evidence before deciding what is worth your own test.

Phoenix APOE4 Research · Reviewed by Kevin Tran, APOE4/4 carrier and founder · Data through 2026-08-23 · How to read this research

How to read this

Observational research: real APOE4 carriers tracked over time, each compared with their own earlier self. Members chose their interventions, with no randomisation or placebo group. Everything else they changed is shown beside each result.

Read the full methods and limits

Questions about Total cholesterol

What can improve Total cholesterol for APOE4 carriers?

For APOE4 carriers, Phoenix has published positive evidence for Curcumin, Niacin, Ezetimibe, Probiotics, Psyllium, and Statin family against Total cholesterol. Member #1EB8E9's Total cholesterol moved from 232 to 202 mg/dL in 106 days. Member #4025C9's Total cholesterol moved from 239 to 205 mg/dL in 255 days. The same three members' total cholesterol fell alongside their LDL cholesterol. Two curated probiotic cases lowered total cholesterol; one moved from 199 to 171 mg/dL and the other fell 17.7%. Member #8DF8C2 lowered total cholesterol from 345 to 154 mg/dL in the same 70-day window as her LDL drop, on the same ezetimibe-and-psyllium combination. Member #5AA27F's total cholesterol fell 41.6% in the longer statin arc; paired values and exact elapsed days were not printed.

What has Phoenix measured against Total cholesterol?

Phoenix has measured 6 interventions against Total cholesterol: 6 positive. See the table below.

Every intervention measured against Total cholesterol

Interventions measured against Total cholesterol
InterventionWhat we observedEvidence status
CurcuminMember #1EB8E9's Total cholesterol moved from 232 to 202 mg/dL in 106 days.Repeated positive
NiacinMember #4025C9's Total cholesterol moved from 239 to 205 mg/dL in 255 days.Repeated positive
EzetimibeThe same three members' total cholesterol fell alongside their LDL cholesterol.Repeated positive
ProbioticsTwo curated probiotic cases lowered total cholesterol; one moved from 199 to 171 mg/dL and the other fell 17.7%.Repeated positive
PsylliumMember #8DF8C2 lowered total cholesterol from 345 to 154 mg/dL in the same 70-day window as her LDL drop, on the same ezetimibe-and-psyllium combination.Repeated positive
Statin familyMember #5AA27F's total cholesterol fell 41.6% in the longer statin arc; paired values and exact elapsed days were not printed.Repeated positive

What changed for real APOE4 carriers?

Search by health goal or intervention to see what changed for real members, including results that moved the wrong way.

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Cholesterol and heart risk · Lower total cholesterol · 6 interventions shown.

Health goalCholesterol and heart risk
SubgoalLower total cholesterol

Lower total cholesterol

Interventions tested: 6

Curcumin

SupplementsOutcomes: 1

Total cholesterol: Decrease 30–66 mg/dL

Cases: 2Case range

Details

Member #1EB8E9's Total cholesterol moved from 232 to 202 mg/dL in 106 days.

Curcumin

✓Repeated positive

Member #1EB8E9's Total cholesterol moved from 232 to 202 mg/dL in 106 days.

Selected member cases

  1. Phoenix memberAPOE3/462female

    Total cholesterol

    Before201After135mg/dL-32.8%

    223 days between measurements

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat Total cholesterol after a dated Curcumin window.

  2. Phoenix memberAPOE4/457female

    Total cholesterol

    Before232After202mg/dL-12.9%

    106 days between measurements

    Full stack credited: Curcumin (lead), Probiotics (co), Bergamot (co).

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat Total cholesterol after a dated Curcumin window.

logged members
2
members with repeats
2
observations
2
measurements
4

Full record

Ezetimibe

MedicationsOutcomes: 1

Total cholesterol: Decrease 14.9–79 mg/dL

Cases: 5Case range

Details

The same three members' total cholesterol fell alongside their LDL cholesterol.

Ezetimibe

✓Repeated positive

The same three members' total cholesterol fell alongside their LDL cholesterol.

Selected member cases

  1. Phoenix memberAPOE4/458female

    Total cholesterol

    Before122After107.1mg/dL-12.2%

    66 days between measurements

    Full stack credited: Ezetimibe (lead), Levothyroxine (co), Statin (undated).

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat Total cholesterol after a dated Ezetimibe window.

  2. Phoenix memberAPOE4/467female

    Total cholesterol

    Before269After190mg/dL-29.4%

    133 days between measurements

    Full stack credited: Ezetimibe (lead), Psyllium (co), Curcumin (undated).

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat Total cholesterol after a dated Ezetimibe window.

  3. Phoenix memberAPOE4/476female

    Total cholesterol

    Before146After113mg/dL-22.6%

    308 days between measurements

    Full stack credited: Ezetimibe (lead), Rosuvastatin (undated), Curcumin (undated), Berberine (undated).

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat Total cholesterol after a dated Ezetimibe window.

  4. Phoenix memberAPOE3/451female

    Total cholesterol

    Before271After239mg/dL-11.8%

    148 days between measurements

    Full stack credited: Ezetimibe (lead), Berberine (co).

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat Total cholesterol after a dated Ezetimibe window.

  5. Phoenix memberAPOE4/461male

    Total cholesterol

    Before281After204mg/dL-27.4%

    91 days between measurements

    Full stack credited: Ezetimibe (lead), Lactobacillus reuteri (co), Psyllium (co), Berberine (undated).

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat Total cholesterol after a dated Ezetimibe window.

logged members
5
members with repeats
5
observations
5
measurements
10

Full record

Niacin

SupplementsOutcomes: 1

Total cholesterol: Decrease 15–34 mg/dL

Cases: 2Case range

Details

Member #4025C9's Total cholesterol moved from 239 to 205 mg/dL in 255 days.

Niacin

✓Repeated positive

Member #4025C9's Total cholesterol moved from 239 to 205 mg/dL in 255 days.

Selected member cases

  1. Phoenix memberAPOE4/456female

    Total cholesterol

    Before239After205mg/dL-14.2%

    255 days between measurements

    Full stack credited: Niacin (lead), Niacinamide (co), Curcumin (co), Turmeric (co).

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat Total cholesterol after a dated Niacin window.

  2. Phoenix memberAPOE4/453female

    Total cholesterol

    Before212After197mg/dL-7.1%

    110 days between measurements

    Full stack credited: Niacinamide (lead), Curcumin (co).

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat Total cholesterol after a dated Niacin window.

logged members
2
members with repeats
2
observations
2
measurements
4

Full record

Probiotics

SupplementsOutcomes: 1

Total cholesterol: Decrease 28 mg/dL

Cases: 2

Details

Two curated probiotic cases lowered total cholesterol; one moved from 199 to 171 mg/dL and the other fell 17.7%.

Probiotics

✓Repeated positive

Two curated probiotic cases lowered total cholesterol; one moved from 199 to 171 mg/dL and the other fell 17.7%.

Selected member cases

  1. Phoenix member69female

    Total cholesterol fell 17.7%; the public report does not print the paired values.

    Full stack credited: Bergamot (lead), Red yeast rice (undated), Curcumin (undated), Lactobacillus reuteri (co).

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat Total cholesterol after a dated Probiotics window.

  2. Phoenix memberAPOE3/448female

    Total cholesterol

    Before199After171mg/dL-14.1%

    59 days between measurements

    Full stack credited: Statin (lead), Probiotics (co), Berberine (undated), Lysoveta (DHA-LPC) (undated).

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat Total cholesterol after a dated Probiotics window.

observations
2
measurements
4

Full record

Psyllium

SupplementsOutcomes: 1

Total cholesterol: Decrease 13.6–191 mg/dL

Cases: 3Case range

Details

Member #8DF8C2 lowered total cholesterol from 345 to 154 mg/dL in the same 70-day window as her LDL drop, on the same ezetimibe-and-psyllium combination.

Psyllium

✓Repeated positive

Member #8DF8C2 lowered total cholesterol from 345 to 154 mg/dL in the same 70-day window as her LDL drop, on the same ezetimibe-and-psyllium combination.

Selected member cases

  1. Phoenix memberAPOE4/455female

    Total cholesterol

    Before345After154mg/dL-55.4%

    70 days between measurements

    Full stack credited: Ezetimibe (lead), Psyllium (co).

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat Total cholesterol after a dated Psyllium window.

  2. Phoenix memberAPOE4/467female

    Total cholesterol

    Before145After129mg/dL-11%

    151 days between measurements

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat Total cholesterol after a dated Psyllium window.

  3. Phoenix memberAPOE4/464female

    Total cholesterol

    Before205After191.4mg/dL-6.6%

    162 days between measurements

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat Total cholesterol after a dated Psyllium window.

logged members
3
members with repeats
3
observations
3
measurements
6

Full record

Statin family

MedicationsOutcomes: 1

Total cholesterol: Decrease 23–107 mg/dL

Cases: 2Case range

Details

Member #5AA27F's total cholesterol fell 41.6% in the longer statin arc; paired values and exact elapsed days were not printed.

Statin family

✓Repeated positive

Member #5AA27F's total cholesterol fell 41.6% in the longer statin arc; paired values and exact elapsed days were not printed.

Selected member cases

  1. Phoenix memberAPOE3/462female

    Total cholesterol

    Before257After150mg/dL-41.6%

    353 days between measurements

    Full stack credited: Statin (lead), Citicoline (co), Curcumin (undated), Estradiol patch (undated).

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat Total cholesterol after a dated Statin family window.

  2. Phoenix memberAPOE4/455male

    Total cholesterol

    Before98After75mg/dL-23.5%

    174 days between measurements

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat Total cholesterol after a dated Statin family window.

logged members
2
members with repeats
2
observations
2
measurements
4

Full record

The Beat the Odds Study

The 43-page study: what members tried, how their bloodwork and wearable results changed, and what else changed alongside them.

Download the Beat the Odds Study

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