Browse by intervention

Estradiol vaginal: what it changed, and what it did not

One intervention, every measured benefit and result that did not improve. See who it moved for, where it stayed neutral or went the other way, and the next hypothesis Phoenix can validate.

Phoenix APOE4 Research · Reviewed by Kevin Tran, APOE4/4 carrier and founder · Data through 2026-08-23 · How to read this research

How to read this

Observational research: real APOE4 carriers tracked over time, each compared with their own earlier self. Members chose their interventions, with no randomisation or placebo group. Everything else they changed is shown beside each result.

Read the full methods and limits
The Phoenix Beat the Odds Study

The study behind the Navigator.

Read the 43-page study: what members tried, how their results changed, and what else they changed at the same time.

476
Phoenix members
30,737
Biomarker readings
139
Members with 2+ blood draws
176
Intervention signals

Data through 2026-08-23

Unlock the Navigator. Get the study.

Enter your APOE status and email to unlock every result and get the 43-page PDF.

Instant report access · the next edition in your inbox the day it publishes · No spam

Key findings

Phoenix has measured Estradiol vaginal against 1 exact outcome for APOE4 carriers. Member #EFF528's HDL cholesterol moved from 53 to 79 mg/dL in 338 days.

Estradiol vaginal evidence by outcome
OutcomeDirectionWhat we observed
HDL cholesterolPositive individual resultMember #EFF528's HDL cholesterol moved from 53 to 79 mg/dL in 338 days.

Questions about Estradiol vaginal

What is the effect of Estradiol vaginal for APOE4 carriers?

Phoenix has measured Estradiol vaginal against 1 exact outcome for APOE4 carriers. Member #EFF528's HDL cholesterol moved from 53 to 79 mg/dL in 338 days.

Does Estradiol vaginal change HDL cholesterol for APOE4 carriers?

Member #EFF528's HDL cholesterol moved from 53 to 79 mg/dL in 338 days. Support: 1 logged members, 1 members with repeats, 1 observations, 2 measurements.

Turn evidence into your next test

I built this so nobody has to be the first to try something.

476 members have already tried, measured and logged. Join Phoenix and your next blood draw joins the same Navigator you are reading.

Join Phoenix