What is the effect of Estradiol vaginal for APOE4 carriers?
Phoenix has measured Estradiol vaginal against 1 exact outcome for APOE4 carriers. Member #EFF528's HDL cholesterol moved from 53 to 79 mg/dL in 338 days.
One intervention, every measured benefit and result that did not improve. See who it moved for, where it stayed neutral or went the other way, and the next hypothesis Phoenix can validate.
Phoenix APOE4 Research · Reviewed by Kevin Tran, APOE4/4 carrier and founder · Data through 2026-08-23 · How to read this research
How to read this
Observational research: real APOE4 carriers tracked over time, each compared with their own earlier self. Members chose their interventions, with no randomisation or placebo group. Everything else they changed is shown beside each result.
Read the full methods and limitsRead the 43-page study: what members tried, how their results changed, and what else they changed at the same time.
Data through 2026-08-23
Enter your APOE status and email to unlock every result and get the 43-page PDF.
Phoenix has measured Estradiol vaginal against 1 exact outcome for APOE4 carriers. Member #EFF528's HDL cholesterol moved from 53 to 79 mg/dL in 338 days.
| Outcome | Direction | What we observed |
|---|---|---|
| HDL cholesterol | Positive individual result | Member #EFF528's HDL cholesterol moved from 53 to 79 mg/dL in 338 days. |
Phoenix has measured Estradiol vaginal against 1 exact outcome for APOE4 carriers. Member #EFF528's HDL cholesterol moved from 53 to 79 mg/dL in 338 days.
Member #EFF528's HDL cholesterol moved from 53 to 79 mg/dL in 338 days. Support: 1 logged members, 1 members with repeats, 1 observations, 2 measurements.
Turn evidence into your next test
476 members have already tried, measured and logged. Join Phoenix and your next blood draw joins the same Navigator you are reading.
Full research index
Choose an outcome, like LDL cholesterol or sleep, or an intervention, like training: both paths open the same measured records.