One intervention, every measured benefit and result that did not improve. See who it moved for, where it stayed neutral or went the other way, and the next hypothesis Phoenix can validate.
Phoenix APOE4 Research · Reviewed by Kevin Tran, APOE4/4 carrier and founder · Data through 2026-08-23 · How to read this research
How to read this
Observational research: real APOE4 carriers tracked over time, each compared with their own earlier self. Members chose their interventions, with no randomisation or placebo group. Everything else they changed is shown beside each result.
Read the full methods and limitsPhoenix has measured Vitamin D3 against 1 exact outcome for APOE4 carriers. Three members raised their vitamin D level on a Vitamin D3-led combination: 28 to 102 ng/mL in 126 days, 32.1 to 65.8 ng/mL in 69 days, and 33 to 54 ng/mL in 120 days.
| Outcome | Direction | What we observed |
|---|---|---|
| Vitamin D level | Repeated positive | Three members raised their vitamin D level on a Vitamin D3-led combination: 28 to 102 ng/mL in 126 days, 32.1 to 65.8 ng/mL in 69 days, and 33 to 54 ng/mL in 120 days. |
Phoenix has measured Vitamin D3 against 1 exact outcome for APOE4 carriers. Three members raised their vitamin D level on a Vitamin D3-led combination: 28 to 102 ng/mL in 126 days, 32.1 to 65.8 ng/mL in 69 days, and 33 to 54 ng/mL in 120 days.
Three members raised their vitamin D level on a Vitamin D3-led combination: 28 to 102 ng/mL in 126 days, 32.1 to 65.8 ng/mL in 69 days, and 33 to 54 ng/mL in 120 days. Support: 161 logged members, 46 members with repeats, 2 observations, 92 measurements.
Search by health goal or intervention to see what changed for real members, including results that moved the wrong way.
Vitamin D3 · 2 outcomes shown.
LDL cholesterol: Increase 26 %
Cases: 1
Under review
One clean curated APOE4/4 case moved opposite the goal, with LDL cholesterol rising 26% across 191 days.
Vitamin D3
?Collecting evidenceOne clean curated APOE4/4 case moved opposite the goal, with LDL cholesterol rising 26% across 191 days.
Little published human data on this link yet.
Collecting evidence
Vitamin D3 is being tracked against LDL cholesterol, but Phoenix has not yet published a ranked result for this exact question.
Every carrier who logs a dated start and a repeat test moves this page closer to an answer, including you.
Get an email when Phoenix publishes a meaningful update. At most one combined update each week.
This result is under review: Not published as a finding: the only mechanism-plausible driver in this window has too little confirmed exposure before the after-draw for the window length, under the minimum-exposure rule adopted this release. The LDL rise is real. Phoenix does not attribute it to vitamin D3.
Vitamin D level: Increase 14.6–74 ng/mL
Cases: 5Case range
Three members raised their vitamin D level on a Vitamin D3-led combination: 28 to 102 ng/mL in 126 days, 32.1 to 65.8 ng/mL in 69 days, and 33 to 54 ng/mL in 120 days.
Vitamin D3
✓Repeated positiveThree members raised their vitamin D level on a Vitamin D3-led combination: 28 to 102 ng/mL in 126 days, 32.1 to 65.8 ng/mL in 69 days, and 33 to 54 ng/mL in 120 days.
Vitamin D level
Before28After102ng/mL+264.3%
126 days between measurements
Full stack credited: Vitamin D3 (lead), Lysoveta (DHA-LPC) (co).
What else changed: no nearby starts were recorded.
Next study: repeat Vitamin D level after a dated Vitamin D3 window.
Vitamin D level
Before49After69ng/mL+40.8%
207 days between measurements
Full stack credited: Vitamin D3 (lead), Lysoveta (DHA-LPC) (co), Omega-3 (co).
What else changed: no nearby starts were recorded.
Next study: repeat Vitamin D level after a dated Vitamin D3 window.
Vitamin D level
Before33After54ng/mL+63.6%
120 days between measurements
Full stack credited: Vitamin D3 (lead), Omega-3 (co).
What else changed: no nearby starts were recorded.
Next study: repeat Vitamin D level after a dated Vitamin D3 window.
Vitamin D level
Before62.1After76.7ng/mL+23.5%
147 days between measurements
Full stack credited: Vitamin D3 (lead), Lysoveta (DHA-LPC) (co), Omega-3 (co).
What else changed: no nearby starts were recorded.
Next study: repeat Vitamin D level after a dated Vitamin D3 window.
Vitamin D level
Before32After66ng/mL+106.3%
69 days between measurements
Full stack credited: Vitamin D3 (lead), Omega-3 (co).
What else changed: no nearby starts were recorded.
Next study: repeat Vitamin D level after a dated Vitamin D3 window.
The 43-page study: what members tried, how their bloodwork and wearable results changed, and what else changed alongside them.
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Choose an outcome, like LDL cholesterol or sleep, or an intervention, like training: both paths open the same measured records.