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Ezetimibe: what it changed, and what it did not

One intervention, every measured benefit and result that did not improve. See who it moved for, where it stayed neutral or went the other way, and the next hypothesis Phoenix can validate.

Phoenix APOE4 Research · Reviewed by Kevin Tran, APOE4/4 carrier and founder · Data through 2026-08-23 · How to read this research

How to read this

Observational research: real APOE4 carriers tracked over time, each compared with their own earlier self. Members chose their interventions, with no randomisation or placebo group. Everything else they changed is shown beside each result.

Read the full methods and limits

Key findings

Phoenix has measured Ezetimibe against 5 exact outcomes for APOE4 carriers. Member #29E727 lowered ApoB from 131 to 90 mg/dL in 133 days on an ezetimibe-led combination. Member #6FAEFA's HDL cholesterol moved from 74 to 89 mg/dL in 70 days. Three members lowered LDL cholesterol in windows where ezetimibe was the most mechanistically established component of a larger combination. The same three members' total cholesterol fell alongside their LDL cholesterol. Member #B50FCD's Triglycerides moved from 59.4 to 46.9 mg/dL in 85 days.

Ezetimibe evidence by outcome
OutcomeDirectionWhat we observed
Apolipoprotein BRepeated positiveMember #29E727 lowered ApoB from 131 to 90 mg/dL in 133 days on an ezetimibe-led combination.
HDL cholesterolRepeated positiveMember #6FAEFA's HDL cholesterol moved from 74 to 89 mg/dL in 70 days.
LDL cholesterolRepeated positiveThree members lowered LDL cholesterol in windows where ezetimibe was the most mechanistically established component of a larger combination.
Total cholesterolRepeated positiveThe same three members' total cholesterol fell alongside their LDL cholesterol.
TriglyceridesPositive individual resultMember #B50FCD's Triglycerides moved from 59.4 to 46.9 mg/dL in 85 days.

Questions about Ezetimibe

What is the effect of Ezetimibe for APOE4 carriers?

Phoenix has measured Ezetimibe against 5 exact outcomes for APOE4 carriers. Member #29E727 lowered ApoB from 131 to 90 mg/dL in 133 days on an ezetimibe-led combination. Member #6FAEFA's HDL cholesterol moved from 74 to 89 mg/dL in 70 days. Three members lowered LDL cholesterol in windows where ezetimibe was the most mechanistically established component of a larger combination. The same three members' total cholesterol fell alongside their LDL cholesterol. Member #B50FCD's Triglycerides moved from 59.4 to 46.9 mg/dL in 85 days.

Does Ezetimibe change Apolipoprotein B for APOE4 carriers?

Member #29E727 lowered ApoB from 131 to 90 mg/dL in 133 days on an ezetimibe-led combination. Support: 2 logged members, 2 members with repeats, 2 observations, 4 measurements.

Does Ezetimibe change HDL cholesterol for APOE4 carriers?

Member #6FAEFA's HDL cholesterol moved from 74 to 89 mg/dL in 70 days. Support: 4 logged members, 4 members with repeats, 4 observations, 8 measurements.

Does Ezetimibe change LDL cholesterol for APOE4 carriers?

Three members lowered LDL cholesterol in windows where ezetimibe was the most mechanistically established component of a larger combination. Support: 4 logged members, 4 members with repeats, 4 observations, 8 measurements.

Does Ezetimibe change Total cholesterol for APOE4 carriers?

The same three members' total cholesterol fell alongside their LDL cholesterol. Support: 5 logged members, 5 members with repeats, 5 observations, 10 measurements.

Does Ezetimibe change Triglycerides for APOE4 carriers?

Member #B50FCD's Triglycerides moved from 59.4 to 46.9 mg/dL in 85 days. Support: 1 logged members, 1 members with repeats, 1 observations, 2 measurements.

What changed for real APOE4 carriers?

Search by health goal or intervention to see what changed for real members, including results that moved the wrong way.

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Ezetimibe · 5 outcomes shown.

Intervention categoryMedications
InterventionEzetimibe

Ezetimibe

MedicationsOutcomes: 5

Apolipoprotein B: Decrease 36–41 mg/dL

Cases: 2Case range

Details

Member #29E727 lowered ApoB from 131 to 90 mg/dL in 133 days on an ezetimibe-led combination.

Ezetimibe

✓Repeated positive

Member #29E727 lowered ApoB from 131 to 90 mg/dL in 133 days on an ezetimibe-led combination.

Selected member cases

  1. Phoenix memberAPOE4/467female

    Apolipoprotein B

    Before131After90mg/dL-31.3%

    133 days between measurements

    Full stack credited: Ezetimibe (lead), Psyllium (co).

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat Apolipoprotein B after a dated Ezetimibe window.

  2. Phoenix memberAPOE3/451female

    Apolipoprotein B

    Before147After111mg/dL-24.5%

    207 days between measurements

    Full stack credited: Ezetimibe (lead), Berberine (co).

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat Apolipoprotein B after a dated Ezetimibe window.

logged members
2
members with repeats
2
observations
2
measurements
4

Full record

HDL cholesterol: Increase 9–15 mg/dL

Cases: 4Case range

Details

Member #6FAEFA's HDL cholesterol moved from 74 to 89 mg/dL in 70 days.

Ezetimibe

✓Repeated positive

Member #6FAEFA's HDL cholesterol moved from 74 to 89 mg/dL in 70 days.

Selected member cases

  1. Phoenix memberAPOE4/455female

    HDL cholesterol

    Before78After87mg/dL+11.5%

    21 days between measurements

    Full stack credited: Ezetimibe (lead), Omega-3 (co), Lysoveta (DHA-LPC) (undated).

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat HDL cholesterol after a dated Ezetimibe window.

  2. Phoenix memberAPOE4/455female

    HDL cholesterol

    Before69After78mg/dL+13%

    299 days between measurements

    Full stack credited: Ezetimibe (lead), Omega-3 (co).

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat HDL cholesterol after a dated Ezetimibe window.

  3. Phoenix memberAPOE4/458female

    HDL cholesterol

    Before65After74mg/dL+13.8%

    363 days between measurements

    Full stack credited: Ezetimibe (lead), Statin (undated), Omega-3 (co).

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat HDL cholesterol after a dated Ezetimibe window.

  4. Phoenix memberAPOE4/463female

    HDL cholesterol

    Before74After89mg/dL+20.3%

    70 days between measurements

    Full stack credited: Ezetimibe (lead), Lysoveta (DHA-LPC) (co), Omega-3 (co).

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat HDL cholesterol after a dated Ezetimibe window.

logged members
4
members with repeats
4
observations
4
measurements
8

Full record

LDL cholesterol: Decrease 22–52 mg/dL

Cases: 4Case range

Details

Three members lowered LDL cholesterol in windows where ezetimibe was the most mechanistically established component of a larger combination.

Ezetimibe

✓Repeated positive

Three members lowered LDL cholesterol in windows where ezetimibe was the most mechanistically established component of a larger combination.

Selected member cases

  1. Phoenix memberAPOE4/467female

    LDL cholesterol

    Before168After116mg/dL-31%

    133 days between measurements

    Full stack credited: Ezetimibe (lead), Estradiol (co), Psyllium (co), Curcumin (undated).

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat LDL cholesterol after a dated Ezetimibe window.

  2. Phoenix memberAPOE4/476female

    LDL cholesterol

    Before64After42mg/dL-34.4%

    308 days between measurements

    Full stack credited: Ezetimibe (lead), Rosuvastatin (undated), Curcumin (undated), Berberine (undated).

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat LDL cholesterol after a dated Ezetimibe window.

  3. Phoenix memberAPOE3/451female

    LDL cholesterol

    Before190After157mg/dL-17.4%

    148 days between measurements

    Full stack credited: Ezetimibe (lead), Berberine (co), Estradiol vaginal (undated).

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat LDL cholesterol after a dated Ezetimibe window.

  4. Phoenix memberAPOE4/461male

    LDL cholesterol

    Before128After83mg/dL-35.2%

    91 days between measurements

    Full stack credited: Ezetimibe (lead), Lactobacillus reuteri (co), Psyllium (co), Berberine (undated).

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat LDL cholesterol after a dated Ezetimibe window.

logged members
4
members with repeats
4
observations
4
measurements
8

Full record

Total cholesterol: Decrease 14.9–79 mg/dL

Cases: 5Case range

Details

The same three members' total cholesterol fell alongside their LDL cholesterol.

Ezetimibe

✓Repeated positive

The same three members' total cholesterol fell alongside their LDL cholesterol.

Selected member cases

  1. Phoenix memberAPOE4/458female

    Total cholesterol

    Before122After107.1mg/dL-12.2%

    66 days between measurements

    Full stack credited: Ezetimibe (lead), Levothyroxine (co), Statin (undated).

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat Total cholesterol after a dated Ezetimibe window.

  2. Phoenix memberAPOE4/467female

    Total cholesterol

    Before269After190mg/dL-29.4%

    133 days between measurements

    Full stack credited: Ezetimibe (lead), Psyllium (co), Curcumin (undated).

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat Total cholesterol after a dated Ezetimibe window.

  3. Phoenix memberAPOE4/476female

    Total cholesterol

    Before146After113mg/dL-22.6%

    308 days between measurements

    Full stack credited: Ezetimibe (lead), Rosuvastatin (undated), Curcumin (undated), Berberine (undated).

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat Total cholesterol after a dated Ezetimibe window.

  4. Phoenix memberAPOE3/451female

    Total cholesterol

    Before271After239mg/dL-11.8%

    148 days between measurements

    Full stack credited: Ezetimibe (lead), Berberine (co).

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat Total cholesterol after a dated Ezetimibe window.

  5. Phoenix memberAPOE4/461male

    Total cholesterol

    Before281After204mg/dL-27.4%

    91 days between measurements

    Full stack credited: Ezetimibe (lead), Lactobacillus reuteri (co), Psyllium (co), Berberine (undated).

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat Total cholesterol after a dated Ezetimibe window.

logged members
5
members with repeats
5
observations
5
measurements
10

Full record

Triglycerides: Decrease 12.5 mg/dL

Cases: 1

Details

Member #B50FCD's Triglycerides moved from 59.4 to 46.9 mg/dL in 85 days.

Ezetimibe

✓Positive individual result

Member #B50FCD's Triglycerides moved from 59.4 to 46.9 mg/dL in 85 days.

Selected member cases

  1. Phoenix memberAPOE4/458female

    Triglycerides

    Before59.4After46.9mg/dL-21%

    85 days between measurements

    Consistent with established evidence

    Full stack credited: Ezetimibe (lead), Lysoveta (DHA-LPC) (co).

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat Triglycerides after a dated Ezetimibe window.

logged members
1
members with repeats
1
observations
1
measurements
2

Full record

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