Ranked only against the same measurement, in the same unit. See the positive, neutral, opposite-direction and still-collecting evidence before deciding what is worth your own test.
Observational research: real APOE4 carriers tracked over time, each compared with their own earlier self. Members chose their interventions, with no randomisation or placebo group. Everything else they changed is shown beside each result.
For APOE4 carriers, Phoenix has published positive evidence for B-complex, Magnesium glycinate, Vitamin B12, Magnesium threonate, Folate, and Probiotics against Homocysteine. Member #4A4C53's Homocysteine moved from 7.5 to 6.5 µmol/L in 320 days. Member #EFF528's Homocysteine moved from 7 to 6 µmol/L in 207 days. The support cohort has 76 B12-family users and 19 with a repeat homocysteine result; clean eligibility is not published. Two clean curated cases lowered homocysteine by 28.8% and 31.9%; these are two cases, not a response rate. Member #8E1FD7's Homocysteine moved from 8.3 to 7 µmol/L in 175 days. One curated Lactobacillus reuteri case lowered homocysteine 9.9%; the paired values were not published.
What has Phoenix measured against Homocysteine?
Phoenix has measured 6 interventions against Homocysteine: 6 positive. See the table below.
Every intervention measured against Homocysteine
Interventions measured against Homocysteine
Intervention
What we observed
Evidence status
B-complex
Member #4A4C53's Homocysteine moved from 7.5 to 6.5 µmol/L in 320 days.
Repeated positive
Magnesium glycinate
Member #EFF528's Homocysteine moved from 7 to 6 µmol/L in 207 days.
Repeated positive
Vitamin B12
The support cohort has 76 B12-family users and 19 with a repeat homocysteine result; clean eligibility is not published.
Repeated positive
Magnesium threonate
Two clean curated cases lowered homocysteine by 28.8% and 31.9%; these are two cases, not a response rate.
Positive individual result
Folate
Member #8E1FD7's Homocysteine moved from 8.3 to 7 µmol/L in 175 days.
Positive individual result
Probiotics
One curated Lactobacillus reuteri case lowered homocysteine 9.9%; the paired values were not published.
Positive individual result
What changed for real APOE4 carriers?
Search by health goal or intervention to see what changed for real members, including results that moved the wrong way.
Member #4A4C53's Homocysteine moved from 7.5 to 6.5 µmol/L in 320 days.
B-complex
✓Repeated positive
Member #4A4C53's Homocysteine moved from 7.5 to 6.5 µmol/L in 320 days.
Selected member cases
Phoenix memberAPOE4/455female
Homocysteine
Before7.5After6.5µmol/L-13.3%
320 days between measurements
Before7.5
After6.5
Full stack credited: B Complex (lead), Magnesium Glycinate (co).
What else changed and what to test next
What else changed: no nearby starts were recorded.
Next study: repeat Homocysteine after a dated B-complex window.
Phoenix memberAPOE4/454female
Homocysteine
Before7.0After5.1µmol/L-27.1%
68 days between measurements
Before7.0
After5.1
Consistent with established evidence
Full stack credited: B Complex (lead), Vitamin B12 (undated), Folate (undated), Magnesium Glycinate (undated).
This member logs 63 recorded interventions in total, one of Phoenix's largest stacks, not a clean two-item comparison. B Complex is the only item with a formal homocysteine mechanism active the full window.
What else changed and what to test next
What else changed: no nearby starts were recorded.
Next study: repeat Homocysteine after a dated B-complex window.
Phoenix member54male
Homocysteine
Before16.0After12.0µmol/L-25%
60 days between measurements
Before16.0
After12.0
Consistent with established evidence
This member's entire recorded history is four items, the thinnest of the ten, and the comparison stays clean: one credited item, one not, no ambiguity.
What else changed and what to test next
What else changed: no nearby starts were recorded.
Next study: repeat Homocysteine after a dated B-complex window.
Two clean curated cases lowered homocysteine by 28.8% and 31.9%; these are two cases, not a response rate.
Magnesium threonate
✓Positive individual result
Two clean curated cases lowered homocysteine by 28.8% and 31.9%; these are two cases, not a response rate.
Little published human data on this link yet.
Selected member cases
Phoenix memberAPOE4/453male
Homocysteine
Before10.5After7.5µmol/L-28.8%
139 days between measurements
Before10.5
After7.5
Full stack credited: Vitamin B12 (lead), Magnesium threonate (co), Folate (undated), B Complex (undated).
What else changed and what to test next
What else changed: no nearby starts were recorded.
Next study: No human magnesium-threonate homocysteine study was found; B-vitamin exposure is the main alternative to separate.
logged members
142
members with repeats
33
observations
2
measurements
4
Not yet measured: how to test it
No human magnesium-threonate homocysteine study was found; B-vitamin exposure is the main alternative to separate.
How to test it
Baseline
Record a homocysteine result before the dated start.
Duration
84 days
Adherence
Track magnesium and B-vitamin use throughout the window.
Retest
Repeat homocysteine after the planned window.
Falsifier
Homocysteine does not fall in clean magnesium-threonate windows once B-vitamin exposure is dated and separated.
Eligible-member target
40 members
This result is under review: Not published as a finding under the minimum-exposure rule: magnesium threonate has only 6 days of confirmed exposure before the after-draw in a 791-day window, and the other plausible co-drivers are undated and untagged. The other member in this pair keeps this result.