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Psyllium: what it changed, and what it did not

One intervention, every measured benefit and result that did not improve. See who it moved for, where it stayed neutral or went the other way, and the next hypothesis Phoenix can validate.

Phoenix APOE4 Research · Reviewed by Kevin Tran, APOE4/4 carrier and founder · Data through 2026-08-23 · How to read this research

How to read this

Observational research: real APOE4 carriers tracked over time, each compared with their own earlier self. Members chose their interventions, with no randomisation or placebo group. Everything else they changed is shown beside each result.

Read the full methods and limits

Key findings

Phoenix has measured Psyllium against 4 exact outcomes for APOE4 carriers. Member #61477B's Apolipoprotein B moved from 107 to 95 mg/dL in 115 days. LDL cholesterol moved from 263 to 78 mg/dL in 70 days, but an undated ezetimibe entry may be the real actor. Member #8DF8C2 lowered total cholesterol from 345 to 154 mg/dL in the same 70-day window as her LDL drop, on the same ezetimibe-and-psyllium combination. Member #8DF8C2 lowered triglycerides from 70 to 40 mg/dL in the same 70-day window, with an estradiol patch active the full window alongside ezetimibe and Lysoveta.

Psyllium evidence by outcome
OutcomeDirectionWhat we observed
Apolipoprotein BPositive individual resultMember #61477B's Apolipoprotein B moved from 107 to 95 mg/dL in 115 days.
LDL cholesterolRepeated positiveLDL cholesterol moved from 263 to 78 mg/dL in 70 days, but an undated ezetimibe entry may be the real actor.
Total cholesterolRepeated positiveMember #8DF8C2 lowered total cholesterol from 345 to 154 mg/dL in the same 70-day window as her LDL drop, on the same ezetimibe-and-psyllium combination.
TriglyceridesPositive individual resultMember #8DF8C2 lowered triglycerides from 70 to 40 mg/dL in the same 70-day window, with an estradiol patch active the full window alongside ezetimibe and Lysoveta.

Questions about Psyllium

What is the effect of Psyllium for APOE4 carriers?

Phoenix has measured Psyllium against 4 exact outcomes for APOE4 carriers. Member #61477B's Apolipoprotein B moved from 107 to 95 mg/dL in 115 days. LDL cholesterol moved from 263 to 78 mg/dL in 70 days, but an undated ezetimibe entry may be the real actor. Member #8DF8C2 lowered total cholesterol from 345 to 154 mg/dL in the same 70-day window as her LDL drop, on the same ezetimibe-and-psyllium combination. Member #8DF8C2 lowered triglycerides from 70 to 40 mg/dL in the same 70-day window, with an estradiol patch active the full window alongside ezetimibe and Lysoveta.

Does Psyllium change Apolipoprotein B for APOE4 carriers?

Member #61477B's Apolipoprotein B moved from 107 to 95 mg/dL in 115 days. Support: 1 logged members, 1 members with repeats, 1 observations, 2 measurements.

Does Psyllium change LDL cholesterol for APOE4 carriers?

LDL cholesterol moved from 263 to 78 mg/dL in 70 days, but an undated ezetimibe entry may be the real actor. Support: 2 logged members, 2 members with repeats, 2 observations, 4 measurements.

Does Psyllium change Total cholesterol for APOE4 carriers?

Member #8DF8C2 lowered total cholesterol from 345 to 154 mg/dL in the same 70-day window as her LDL drop, on the same ezetimibe-and-psyllium combination. Support: 3 logged members, 3 members with repeats, 3 observations, 6 measurements.

Does Psyllium change Triglycerides for APOE4 carriers?

Member #8DF8C2 lowered triglycerides from 70 to 40 mg/dL in the same 70-day window, with an estradiol patch active the full window alongside ezetimibe and Lysoveta. Support: 1 logged members, 1 members with repeats, 1 observations, 2 measurements.

What changed for real APOE4 carriers?

Search by health goal or intervention to see what changed for real members, including results that moved the wrong way.

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Psyllium · 4 outcomes shown.

Intervention categorySupplements
InterventionPsyllium

Psyllium

SupplementsOutcomes: 4

Apolipoprotein B: Decrease 12 mg/dL

Cases: 1

Details

Member #61477B's Apolipoprotein B moved from 107 to 95 mg/dL in 115 days.

Psyllium

✓Positive individual result

Member #61477B's Apolipoprotein B moved from 107 to 95 mg/dL in 115 days.

Selected member cases

  1. Phoenix memberAPOE4/464female

    Apolipoprotein B

    Before107After95mg/dL-11.2%

    115 days between measurements

    Mixed or inconclusive

    Full stack credited: Psyllium (lead), Omega-3 (co).

    Since this result, ApoB was unchanged at the next draw, then climbed back to 104 mg/dL, close to the 107 mg/dL starting point, in the draw closest to Phoenix's data freeze.

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat Apolipoprotein B after a dated Psyllium window.

logged members
1
members with repeats
1
observations
1
measurements
2

Full record

LDL cholesterol: Decrease 4–185 mg/dL

Cases: 2Case range

Details

LDL cholesterol moved from 263 to 78 mg/dL in 70 days, but an undated ezetimibe entry may be the real actor.

Psyllium

✓Repeated positive

LDL cholesterol moved from 263 to 78 mg/dL in 70 days, but an undated ezetimibe entry may be the real actor.

Selected member cases

  1. Phoenix memberAPOE4/455female

    LDL cholesterol

    Before263After78mg/dL-70.3%

    70 days between measurements

    Full stack credited: Ezetimibe (lead), Psyllium (co), Estradiol patch (co).

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: Psyllium and ezetimibe both have human LDL evidence, but the Phoenix case cannot assign the observed fall while the ezetimibe start is undated.

  2. Phoenix memberAPOE4/467female

    LDL cholesterol

    Before57After53mg/dL-7%

    151 days between measurements

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: Psyllium and ezetimibe both have human LDL evidence, but the Phoenix case cannot assign the observed fall while the ezetimibe start is undated.

logged members
2
members with repeats
2
observations
2
measurements
4
Not yet measured: how to test it

Psyllium and ezetimibe both have human LDL evidence, but the Phoenix case cannot assign the observed fall while the ezetimibe start is undated.

How to test it

Baseline
Record LDL cholesterol before every dated intervention start.
Duration
84 days
Adherence
Track psyllium and ezetimibe separately throughout the window.
Retest
Repeat LDL cholesterol after 12 weeks.
Falsifier
The dated combination does not outperform each intervention tracked separately.
Eligible-member target
40 members

This result is under review: The case stays visible but is excluded from active ranks until every start is dated.

Full record

Total cholesterol: Decrease 13.6–191 mg/dL

Cases: 3Case range

Details

Member #8DF8C2 lowered total cholesterol from 345 to 154 mg/dL in the same 70-day window as her LDL drop, on the same ezetimibe-and-psyllium combination.

Psyllium

✓Repeated positive

Member #8DF8C2 lowered total cholesterol from 345 to 154 mg/dL in the same 70-day window as her LDL drop, on the same ezetimibe-and-psyllium combination.

Selected member cases

  1. Phoenix memberAPOE4/455female

    Total cholesterol

    Before345After154mg/dL-55.4%

    70 days between measurements

    Full stack credited: Ezetimibe (lead), Psyllium (co).

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat Total cholesterol after a dated Psyllium window.

  2. Phoenix memberAPOE4/467female

    Total cholesterol

    Before145After129mg/dL-11%

    151 days between measurements

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat Total cholesterol after a dated Psyllium window.

  3. Phoenix memberAPOE4/464female

    Total cholesterol

    Before205After191.4mg/dL-6.6%

    162 days between measurements

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat Total cholesterol after a dated Psyllium window.

logged members
3
members with repeats
3
observations
3
measurements
6

Full record

Triglycerides: Decrease 30 mg/dL

Cases: 1

Details

Member #8DF8C2 lowered triglycerides from 70 to 40 mg/dL in the same 70-day window, with an estradiol patch active the full window alongside ezetimibe and Lysoveta.

Psyllium

✓Positive individual result

Member #8DF8C2 lowered triglycerides from 70 to 40 mg/dL in the same 70-day window, with an estradiol patch active the full window alongside ezetimibe and Lysoveta.

Selected member cases

  1. Phoenix memberAPOE4/455female

    Triglycerides

    Before70After40mg/dL-42.9%

    70 days between measurements

    Full stack credited: Ezetimibe (lead), Lysoveta (DHA-LPC) (undated), Estradiol patch (co).

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat Triglycerides after a dated Psyllium window.

logged members
1
members with repeats
1
observations
1
measurements
2

Full record

The Beat the Odds Study

The 43-page study: what members tried, how their bloodwork and wearable results changed, and what else changed alongside them.

Download the Beat the Odds Study

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