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Statin family: what it changed, and what it did not

One intervention, every measured benefit and result that did not improve. See who it moved for, where it stayed neutral or went the other way, and the next hypothesis Phoenix can validate.

Phoenix APOE4 Research · Reviewed by Kevin Tran, APOE4/4 carrier and founder · Data through 2026-08-23 · How to read this research

How to read this

Observational research: real APOE4 carriers tracked over time, each compared with their own earlier self. Members chose their interventions, with no randomisation or placebo group. Everything else they changed is shown beside each result.

Read the full methods and limits

Key findings

Phoenix has measured Statin family against 5 exact outcomes for APOE4 carriers. Member #5AA27F lowered ApoB from 98 to 59 mg/dL in 77 days; generic and named statin use counts are not summed. Member #F111C1's HDL cholesterol moved from 36 to 43 mg/dL in 203 days. Member #5AA27F's longer arc moved LDL cholesterol from 161 to 49 mg/dL, about 70% lower; the aggregate statin effect remains unresolved. Member #5AA27F's total cholesterol fell 41.6% in the longer statin arc; paired values and exact elapsed days were not printed. Member #5AA27F's longer statin arc also lowered triglycerides from 67 to 53 mg/dL, both already inside the normal range.

Statin family evidence by outcome
OutcomeDirectionWhat we observed
Apolipoprotein BRepeated positiveMember #5AA27F lowered ApoB from 98 to 59 mg/dL in 77 days; generic and named statin use counts are not summed.
HDL cholesterolRepeated positiveMember #F111C1's HDL cholesterol moved from 36 to 43 mg/dL in 203 days.
LDL cholesterolRepeated positiveMember #5AA27F's longer arc moved LDL cholesterol from 161 to 49 mg/dL, about 70% lower; the aggregate statin effect remains unresolved.
Total cholesterolRepeated positiveMember #5AA27F's total cholesterol fell 41.6% in the longer statin arc; paired values and exact elapsed days were not printed.
TriglyceridesPositive individual resultMember #5AA27F's longer statin arc also lowered triglycerides from 67 to 53 mg/dL, both already inside the normal range.

Questions about Statin family

What is the effect of Statin family for APOE4 carriers?

Phoenix has measured Statin family against 5 exact outcomes for APOE4 carriers. Member #5AA27F lowered ApoB from 98 to 59 mg/dL in 77 days; generic and named statin use counts are not summed. Member #F111C1's HDL cholesterol moved from 36 to 43 mg/dL in 203 days. Member #5AA27F's longer arc moved LDL cholesterol from 161 to 49 mg/dL, about 70% lower; the aggregate statin effect remains unresolved. Member #5AA27F's total cholesterol fell 41.6% in the longer statin arc; paired values and exact elapsed days were not printed. Member #5AA27F's longer statin arc also lowered triglycerides from 67 to 53 mg/dL, both already inside the normal range.

Does Statin family change Apolipoprotein B for APOE4 carriers?

Member #5AA27F lowered ApoB from 98 to 59 mg/dL in 77 days; generic and named statin use counts are not summed. Support: 2 logged members, 2 members with repeats, 2 observations, 4 measurements.

Does Statin family change HDL cholesterol for APOE4 carriers?

Member #F111C1's HDL cholesterol moved from 36 to 43 mg/dL in 203 days. Support: 2 logged members, 2 members with repeats, 2 observations, 4 measurements.

Does Statin family change LDL cholesterol for APOE4 carriers?

Member #5AA27F's longer arc moved LDL cholesterol from 161 to 49 mg/dL, about 70% lower; the aggregate statin effect remains unresolved. Support: 4 logged members, 4 members with repeats, 4 observations, 8 measurements.

Does Statin family change Total cholesterol for APOE4 carriers?

Member #5AA27F's total cholesterol fell 41.6% in the longer statin arc; paired values and exact elapsed days were not printed. Support: 2 logged members, 2 members with repeats, 2 observations, 4 measurements.

Does Statin family change Triglycerides for APOE4 carriers?

Member #5AA27F's longer statin arc also lowered triglycerides from 67 to 53 mg/dL, both already inside the normal range. Support: 1 logged members, 1 members with repeats, 1 observations, 2 measurements.

What changed for real APOE4 carriers?

Search by health goal or intervention to see what changed for real members, including results that moved the wrong way.

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Statin family · 5 outcomes shown.

Intervention categoryMedications
InterventionStatin family

Statin family

MedicationsOutcomes: 5

Apolipoprotein B: Decrease 8–39 mg/dL

Cases: 2Case range

Details

Member #5AA27F lowered ApoB from 98 to 59 mg/dL in 77 days; generic and named statin use counts are not summed.

Statin family

✓Repeated positive

Member #5AA27F lowered ApoB from 98 to 59 mg/dL in 77 days; generic and named statin use counts are not summed.

Selected member cases

  1. Phoenix memberAPOE3/462female

    Apolipoprotein B

    Before98After59mg/dL-39.8%

    112 days between measurements

    Full stack credited: Statin (lead), Citicoline (co).

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat Apolipoprotein B after a dated Statin family window.

  2. Phoenix memberAPOE4/454male

    Apolipoprotein B

    Before69After61mg/dL-11.6%

    203 days between measurements

    Full stack credited: Statin (lead), Probiotics (co).

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat Apolipoprotein B after a dated Statin family window.

logged members
2
members with repeats
2
observations
2
measurements
4

Full record

HDL cholesterol: Increase 7–20 mg/dL

Cases: 2Case range

Details

Member #F111C1's HDL cholesterol moved from 36 to 43 mg/dL in 203 days.

Statin family

✓Repeated positive

Member #F111C1's HDL cholesterol moved from 36 to 43 mg/dL in 203 days.

Selected member cases

  1. Phoenix memberAPOE4/454male

    HDL cholesterol

    Before36After43mg/dL+19.4%

    203 days between measurements

    Full stack credited: Statin (lead), Omega-3 (co).

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat HDL cholesterol after a dated Statin family window.

  2. Phoenix memberAPOE4/466female

    HDL cholesterol

    Before47After67mg/dL+42.6%

    44 days between measurements

    Full stack credited: Rosuvastatin (lead), Omega-3 (co).

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat HDL cholesterol after a dated Statin family window.

logged members
2
members with repeats
2
observations
2
measurements
4

Full record

LDL cholesterol: Decrease 6–112 mg/dL

Cases: 4Case range

Details

Member #5AA27F's longer arc moved LDL cholesterol from 161 to 49 mg/dL, about 70% lower; the aggregate statin effect remains unresolved.

Statin family

✓Repeated positive

Member #5AA27F's longer arc moved LDL cholesterol from 161 to 49 mg/dL, about 70% lower; the aggregate statin effect remains unresolved.

Selected member cases

  1. Phoenix memberAPOE3/462female

    LDL cholesterol

    Before161After49mg/dL-69.6%

    353 days between measurements

    Full stack credited: Statin (lead), Citicoline (co), Curcumin (undated), Estradiol patch (undated).

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat LDL cholesterol after a dated Statin family window.

  2. Phoenix memberAPOE4/454male

    LDL cholesterol

    Before66After60mg/dL-9.1%

    203 days between measurements

    Full stack credited: Statin (lead), Tirzepatide (co), Probiotics (co), Curcumin (co).

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat LDL cholesterol after a dated Statin family window.

  3. Phoenix memberAPOE4/455male

    LDL cholesterol

    Before47After30mg/dL-36.2%

    174 days between measurements

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat LDL cholesterol after a dated Statin family window.

  4. Phoenix memberAPOE4/462male

    LDL cholesterol

    Before111After90mg/dL-18.9%

    157 days between measurements

    Consistent with established evidence

    Full stack credited: Atorvastatin (lead), Ezetimibe (co).

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat LDL cholesterol after a dated Statin family window.

logged members
4
members with repeats
4
observations
4
measurements
8

Full record

Total cholesterol: Decrease 23–107 mg/dL

Cases: 2Case range

Details

Member #5AA27F's total cholesterol fell 41.6% in the longer statin arc; paired values and exact elapsed days were not printed.

Statin family

✓Repeated positive

Member #5AA27F's total cholesterol fell 41.6% in the longer statin arc; paired values and exact elapsed days were not printed.

Selected member cases

  1. Phoenix memberAPOE3/462female

    Total cholesterol

    Before257After150mg/dL-41.6%

    353 days between measurements

    Full stack credited: Statin (lead), Citicoline (co), Curcumin (undated), Estradiol patch (undated).

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat Total cholesterol after a dated Statin family window.

  2. Phoenix memberAPOE4/455male

    Total cholesterol

    Before98After75mg/dL-23.5%

    174 days between measurements

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat Total cholesterol after a dated Statin family window.

logged members
2
members with repeats
2
observations
2
measurements
4

Full record

Triglycerides: Decrease 14 mg/dL

Cases: 1

Details

Member #5AA27F's longer statin arc also lowered triglycerides from 67 to 53 mg/dL, both already inside the normal range.

Statin family

✓Positive individual result

Member #5AA27F's longer statin arc also lowered triglycerides from 67 to 53 mg/dL, both already inside the normal range.

Selected member cases

  1. Phoenix memberAPOE3/462female

    Triglycerides

    Before67After53mg/dL-20.9%

    353 days between measurements

    Full stack credited: Statin (lead), Citicoline (co), Omega-3 (undated), Lysoveta (DHA-LPC) (undated), Curcumin (undated), Estradiol patch (undated).

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat Triglycerides after a dated Statin family window.

logged members
1
members with repeats
1
observations
1
measurements
2

Full record

The Beat the Odds Study

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