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Phoenix APOE4 Research · Reviewed by Kevin Tran, APOE4/4 carrier and founder · Data through 2026-08-23 · How to read this research
How to read this
Observational research: real APOE4 carriers tracked over time, each compared with their own earlier self. Members chose their interventions, with no randomisation or placebo group. Everything else they changed is shown beside each result.
Read the full methods and limitsPhoenix has measured ZenoWell taVNS against 3 exact outcomes for APOE4 carriers. Two curated ZenoWell cases carried 44 and 23 more deep-plus-REM minutes on use nights; five of 40 study members had valid wearable coverage. Member #291BD0's heart-rate variability was 3% higher on ZenoWell use nights. Member #25E479 averaged 522 total sleep minutes on use nights versus 494 on comparison nights across 77 nights.
| Outcome | Direction | What we observed |
|---|---|---|
| Deep plus REM sleep | Repeated positive | Two curated ZenoWell cases carried 44 and 23 more deep-plus-REM minutes on use nights; five of 40 study members had valid wearable coverage. |
| Heart-rate variability | Positive individual result | Member #291BD0's heart-rate variability was 3% higher on ZenoWell use nights. |
| Total sleep duration | Positive individual result | Member #25E479 averaged 522 total sleep minutes on use nights versus 494 on comparison nights across 77 nights. |
Phoenix has measured ZenoWell taVNS against 3 exact outcomes for APOE4 carriers. Two curated ZenoWell cases carried 44 and 23 more deep-plus-REM minutes on use nights; five of 40 study members had valid wearable coverage. Member #291BD0's heart-rate variability was 3% higher on ZenoWell use nights. Member #25E479 averaged 522 total sleep minutes on use nights versus 494 on comparison nights across 77 nights.
Two curated ZenoWell cases carried 44 and 23 more deep-plus-REM minutes on use nights; five of 40 study members had valid wearable coverage. Support: 40 logged members, 5 members with repeats, 2 observations, 228 nights, 228 measurements.
Member #291BD0's heart-rate variability was 3% higher on ZenoWell use nights. Support: 40 logged members, 5 members with repeats, 1 observations.
Member #25E479 averaged 522 total sleep minutes on use nights versus 494 on comparison nights across 77 nights. Support: 40 logged members, 5 members with repeats, 1 observations, 77 nights, 77 measurements.
Search by health goal or intervention to see what changed for real members, including results that moved the wrong way.
ZenoWell taVNS · 3 outcomes shown.
Deep + REM sleep: Increase 23–44 min
Cases: 2Case range
Two curated ZenoWell cases carried 44 and 23 more deep-plus-REM minutes on use nights; five of 40 study members had valid wearable coverage.
ZenoWell taVNS
✓Repeated positiveTwo curated ZenoWell cases carried 44 and 23 more deep-plus-REM minutes on use nights; five of 40 study members had valid wearable coverage.
Little published human data on this link yet.
Use nights carried 44 more deep plus REM minutes across 60 use and 91 non-use nights.
What else changed: no nearby starts were recorded.
Next study: repeat Deep plus REM sleep after a dated ZenoWell taVNS window.
Use nights carried 23 more deep plus REM minutes across 77 total nights.
What else changed: no nearby starts were recorded.
Next study: repeat Deep plus REM sleep after a dated ZenoWell taVNS window.
Heart-rate variability: Increase 3 %
Cases: 1
Member #291BD0's heart-rate variability was 3% higher on ZenoWell use nights.
ZenoWell taVNS
✓Positive individual resultMember #291BD0's heart-rate variability was 3% higher on ZenoWell use nights.
Heart-rate variability was 3% higher on use nights after the larger evidence window resolved July's opposite direction.
What else changed: no nearby starts were recorded.
Next study: repeat Heart-rate variability after a dated ZenoWell taVNS window.
Total sleep: Increase 28 min
Cases: 177 nights
Member #25E479 averaged 522 total sleep minutes on use nights versus 494 on comparison nights across 77 nights.
ZenoWell taVNS
✓Positive individual resultMember #25E479 averaged 522 total sleep minutes on use nights versus 494 on comparison nights across 77 nights.
Little published human data on this link yet.
Use nights averaged 522 total sleep minutes versus 494 on comparison nights across 77 nights.
What else changed: no nearby starts were recorded.
Next study: repeat Total sleep duration after a dated ZenoWell taVNS window.
The 43-page study: what members tried, how their bloodwork and wearable results changed, and what else changed alongside them.
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