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Vitamin B12: what it changed, and what it did not

One intervention, every measured benefit and result that did not improve. See who it moved for, where it stayed neutral or went the other way, and the next hypothesis Phoenix can validate.

Phoenix APOE4 Research · Reviewed by Kevin Tran, APOE4/4 carrier and founder · Data through 2026-08-23 · How to read this research

How to read this

Observational research: real APOE4 carriers tracked over time, each compared with their own earlier self. Members chose their interventions, with no randomisation or placebo group. Everything else they changed is shown beside each result.

Read the full methods and limits

Key findings

Phoenix has measured Vitamin B12 against 2 exact outcomes for APOE4 carriers. The support cohort has 76 B12-family users and 19 with a repeat homocysteine result; clean eligibility is not published. The support cohort has 76 B12-family users and 15 with a repeat vitamin B12 level; clean eligibility is not published.

Vitamin B12 evidence by outcome
OutcomeDirectionWhat we observed
HomocysteineRepeated positiveThe support cohort has 76 B12-family users and 19 with a repeat homocysteine result; clean eligibility is not published.
Vitamin B12 levelPositive individual resultThe support cohort has 76 B12-family users and 15 with a repeat vitamin B12 level; clean eligibility is not published.

Questions about Vitamin B12

What is the effect of Vitamin B12 for APOE4 carriers?

Phoenix has measured Vitamin B12 against 2 exact outcomes for APOE4 carriers. The support cohort has 76 B12-family users and 19 with a repeat homocysteine result; clean eligibility is not published. The support cohort has 76 B12-family users and 15 with a repeat vitamin B12 level; clean eligibility is not published.

Does Vitamin B12 change Homocysteine for APOE4 carriers?

The support cohort has 76 B12-family users and 19 with a repeat homocysteine result; clean eligibility is not published. Support: 78 logged members, 21 members with repeats, 2 observations, 42 measurements.

Does Vitamin B12 change Vitamin B12 level for APOE4 carriers?

The support cohort has 76 B12-family users and 15 with a repeat vitamin B12 level; clean eligibility is not published. Support: 77 logged members, 16 members with repeats, 1 observations, 32 measurements.

What changed for real APOE4 carriers?

Search by health goal or intervention to see what changed for real members, including results that moved the wrong way.

Vitamin B12 · 2 outcomes shown.

Intervention categorySupplements
InterventionVitamin B12

Vitamin B12

SupplementsOutcomes: 2

Homocysteine: Status Not enough data

Vitamin B12 level: Status Not enough data

The Beat the Odds Study

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