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Tirzepatide: what it changed, and what it did not

One intervention, every measured benefit and result that did not improve. See who it moved for, where it stayed neutral or went the other way, and the next hypothesis Phoenix can validate.

Phoenix APOE4 Research · Reviewed by Kevin Tran, APOE4/4 carrier and founder · Data through 2026-08-23 · How to read this research

How to read this

Observational research: real APOE4 carriers tracked over time, each compared with their own earlier self. Members chose their interventions, with no randomisation or placebo group. Everything else they changed is shown beside each result.

Read the full methods and limits

Key findings

Phoenix has measured Tirzepatide against 1 exact outcome for APOE4 carriers. Member #6FAEFA's Insulin moved from 6.3 to 4.2 uIU/mL in 70 days.

Tirzepatide evidence by outcome
OutcomeDirectionWhat we observed
InsulinPositive individual resultMember #6FAEFA's Insulin moved from 6.3 to 4.2 uIU/mL in 70 days.

Questions about Tirzepatide

What is the effect of Tirzepatide for APOE4 carriers?

Phoenix has measured Tirzepatide against 1 exact outcome for APOE4 carriers. Member #6FAEFA's Insulin moved from 6.3 to 4.2 uIU/mL in 70 days.

Does Tirzepatide change Insulin for APOE4 carriers?

Member #6FAEFA's Insulin moved from 6.3 to 4.2 uIU/mL in 70 days. Support: 1 logged members, 1 members with repeats, 1 observations, 2 measurements.

What changed for real APOE4 carriers?

Search by health goal or intervention to see what changed for real members, including results that moved the wrong way.

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Tirzepatide · 1 outcome shown.

Intervention categoryMedications
InterventionTirzepatide

Tirzepatide

MedicationsOutcomes: 1

Insulin: Decrease 2.1 uIU/mL

Cases: 1

Details

Member #6FAEFA's Insulin moved from 6.3 to 4.2 uIU/mL in 70 days.

Tirzepatide

✓Positive individual result

Member #6FAEFA's Insulin moved from 6.3 to 4.2 uIU/mL in 70 days.

Selected member cases

  1. Phoenix memberAPOE4/463female

    Insulin

    Before6.3After4.2uIU/mL-33.3%

    70 days between measurements

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat Insulin after a dated Tirzepatide window.

logged members
1
members with repeats
1
observations
1
measurements
2

Full record

The Beat the Odds Study

The 43-page study: what members tried, how their bloodwork and wearable results changed, and what else changed alongside them.

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