Estradiol patch: what it changed, and what it did not
One intervention, every measured benefit and result that did not improve. See who it moved for, where it stayed neutral or went the other way, and the next hypothesis Phoenix can validate.
Observational research: real APOE4 carriers tracked over time, each compared with their own earlier self. Members chose their interventions, with no randomisation or placebo group. Everything else they changed is shown beside each result.
Phoenix has measured Estradiol patch against 4 exact outcomes for APOE4 carriers. Member #FBD61B's Glucose moved from 90.091 to 73.3341 mg/dL in 292 days. Member #D9A2BF's HDL cholesterol moved from 32 to 41 mg/dL, about 28% higher, across six months. Member #D9A2BF's LDL cholesterol moved opposite the goal, rising 13% while HDL and triglycerides improved. Member #D9A2BF's triglycerides moved from 230 to 146 mg/dL, about 37% lower, across six months.
Estradiol patch evidence by outcome
Outcome
Direction
What we observed
Glucose
Positive individual result
Member #FBD61B's Glucose moved from 90.091 to 73.3341 mg/dL in 292 days.
HDL cholesterol
Repeated positive
Member #D9A2BF's HDL cholesterol moved from 32 to 41 mg/dL, about 28% higher, across six months.
LDL cholesterol
Opposite direction
Member #D9A2BF's LDL cholesterol moved opposite the goal, rising 13% while HDL and triglycerides improved.
Triglycerides
Positive individual result
Member #D9A2BF's triglycerides moved from 230 to 146 mg/dL, about 37% lower, across six months.
Questions about Estradiol patch
What is the effect of Estradiol patch for APOE4 carriers?
Phoenix has measured Estradiol patch against 4 exact outcomes for APOE4 carriers. Member #FBD61B's Glucose moved from 90.091 to 73.3341 mg/dL in 292 days. Member #D9A2BF's HDL cholesterol moved from 32 to 41 mg/dL, about 28% higher, across six months. Member #D9A2BF's LDL cholesterol moved opposite the goal, rising 13% while HDL and triglycerides improved. Member #D9A2BF's triglycerides moved from 230 to 146 mg/dL, about 37% lower, across six months.
Does Estradiol patch change Glucose for APOE4 carriers?
Member #FBD61B's Glucose moved from 90.091 to 73.3341 mg/dL in 292 days. Support: 1 logged members, 1 members with repeats, 1 observations, 2 measurements.
Does Estradiol patch change HDL cholesterol for APOE4 carriers?
Member #D9A2BF's HDL cholesterol moved from 32 to 41 mg/dL, about 28% higher, across six months. Support: 35 logged members, 2 members with repeats, 2 observations, 4 measurements.
Does Estradiol patch change LDL cholesterol for APOE4 carriers?
Member #D9A2BF's LDL cholesterol moved opposite the goal, rising 13% while HDL and triglycerides improved. Support: 35 logged members, 2 members with repeats, 2 observations, 4 measurements.
Does Estradiol patch change Triglycerides for APOE4 carriers?
Member #D9A2BF's triglycerides moved from 230 to 146 mg/dL, about 37% lower, across six months. Support: 34 logged members, 1 members with repeats, 1 observations, 2 measurements.
What changed for real APOE4 carriers?
Search by health goal or intervention to see what changed for real members, including results that moved the wrong way.
Member #D9A2BF's HDL cholesterol moved from 32 to 41 mg/dL, about 28% higher, across six months.
Estradiol patch
✓Repeated positive
Member #D9A2BF's HDL cholesterol moved from 32 to 41 mg/dL, about 28% higher, across six months.
Selected member cases
Phoenix memberAPOE4/457female
HDL cholesterol
Before46.4After59.2mg/dL+27.5%
292 days between measurements
Before46.4
After59.2
Consistent with established evidence
What else changed and what to test next
What else changed: no nearby starts were recorded.
Next study: One member raised HDL 28% and lowered triglycerides 37% on a confirmed estradiol patch start. Estrogen raising HDL is established; the patch route also avoids oral estrogens triglyceride-raising effect. The 42-member HRT cluster is the pool to confirm both markers.
Phoenix memberAPOE3/457female
HDL cholesterol
Before32After41mg/dL+28.1%
179 days between measurements
Before32
After41
Full stack credited: Estradiol patch (lead), Estradiol transdermal gel (co), Omega-3 (undated), Progesterone (co).
What else changed and what to test next
What else changed: no nearby starts were recorded.
Next study: One member raised HDL 28% and lowered triglycerides 37% on a confirmed estradiol patch start. Estrogen raising HDL is established; the patch route also avoids oral estrogens triglyceride-raising effect. The 42-member HRT cluster is the pool to confirm both markers.
logged members
35
members with repeats
2
observations
2
measurements
4
Not yet measured: how to test it
One member raised HDL 28% and lowered triglycerides 37% on a confirmed estradiol patch start. Estrogen raising HDL is established; the patch route also avoids oral estrogens triglyceride-raising effect. The 42-member HRT cluster is the pool to confirm both markers.
How to test it
Baseline
Blood draw before the dated estradiol start
Duration
90 days
Adherence
Confirmed active prescription for the full window
Retest
Repeat HDL cholesterol and triglycerides after at least 90 days
Falsifier
If 40 members with a dated estradiol start and repeat HDL and triglycerides show no consistent direction, the single-member result does not generalise to the HRT cluster.