Ranked only against the same measurement, in the same unit. See the positive, neutral, opposite-direction and still-collecting evidence before deciding what is worth your own test.
Phoenix APOE4 Research · Reviewed by Kevin Tran, APOE4/4 carrier and founder · Data through 2026-08-23 · How to read this research
How to read this
Observational research: real APOE4 carriers tracked over time, each compared with their own earlier self. Members chose their interventions, with no randomisation or placebo group. Everything else they changed is shown beside each result.
Read the full methods and limitsFor APOE4 carriers, Phoenix has published positive evidence for Training and workouts and ZenoWell taVNS against Heart-rate variability. Member #B2E9BC's next-day HRV was 29% to 32% higher across two computations. A separate case was not published as a finding. Member #291BD0's heart-rate variability was 3% higher on ZenoWell use nights.
Phoenix has measured 2 interventions against Heart-rate variability: 2 positive. See the table below.
| Intervention | What we observed | Evidence status |
|---|---|---|
| Training and workouts | Member #B2E9BC's next-day HRV was 29% to 32% higher across two computations. A separate case was not published as a finding. | Positive individual result |
| ZenoWell taVNS | Member #291BD0's heart-rate variability was 3% higher on ZenoWell use nights. | Positive individual result |
Search by health goal or intervention to see what changed for real members, including results that moved the wrong way.
Recovery · Improve heart-rate variability · 2 interventions shown.
Heart-rate variability: Increase 30.5 %
Cases: 1
Member #B2E9BC's next-day HRV was 29% to 32% higher across two computations. A separate case was not published as a finding.
Training and workouts
✓Positive individual resultMember #B2E9BC's next-day HRV was 29% to 32% higher across two computations. A separate case was not published as a finding.
Next-day HRV was 29% to 32% higher across two independent computations.
What else changed: no nearby starts were recorded.
Next study: repeat Heart-rate variability after a dated Training and workouts window.
This result was not published as a finding: A different July case did not meet Phoenix’s review standard.
Heart-rate variability: Increase 3 %
Cases: 1
Member #291BD0's heart-rate variability was 3% higher on ZenoWell use nights.
ZenoWell taVNS
✓Positive individual resultMember #291BD0's heart-rate variability was 3% higher on ZenoWell use nights.
Heart-rate variability was 3% higher on use nights after the larger evidence window resolved July's opposite direction.
What else changed: no nearby starts were recorded.
Next study: repeat Heart-rate variability after a dated ZenoWell taVNS window.
The 43-page study: what members tried, how their bloodwork and wearable results changed, and what else changed alongside them.
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