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Niacin: what it changed, and what it did not

One intervention, every measured benefit and result that did not improve. See who it moved for, where it stayed neutral or went the other way, and the next hypothesis Phoenix can validate.

Phoenix APOE4 Research · Reviewed by Kevin Tran, APOE4/4 carrier and founder · Data through 2026-08-23 · How to read this research

How to read this

Observational research: real APOE4 carriers tracked over time, each compared with their own earlier self. Members chose their interventions, with no randomisation or placebo group. Everything else they changed is shown beside each result.

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The Phoenix Beat the Odds Study

The study behind the Navigator.

Read the 43-page study: what members tried, how their results changed, and what else they changed at the same time.

476
Phoenix members
30,737
Biomarker readings
139
Members with 2+ blood draws
176
Intervention signals

Data through 2026-08-23

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Key findings

Phoenix has measured Niacin against 3 exact outcomes for APOE4 carriers. Member #4025C9's LDL cholesterol moved from 135 to 121 mg/dL in 255 days. Member #4025C9's Total cholesterol moved from 239 to 205 mg/dL in 255 days. Member #4025C9's Triglycerides moved from 119 to 76 mg/dL in 255 days.

Niacin evidence by outcome
OutcomeDirectionWhat we observed
LDL cholesterolRepeated positiveMember #4025C9's LDL cholesterol moved from 135 to 121 mg/dL in 255 days.
Total cholesterolRepeated positiveMember #4025C9's Total cholesterol moved from 239 to 205 mg/dL in 255 days.
TriglyceridesPositive individual resultMember #4025C9's Triglycerides moved from 119 to 76 mg/dL in 255 days.

Questions about Niacin

What is the effect of Niacin for APOE4 carriers?

Phoenix has measured Niacin against 3 exact outcomes for APOE4 carriers. Member #4025C9's LDL cholesterol moved from 135 to 121 mg/dL in 255 days. Member #4025C9's Total cholesterol moved from 239 to 205 mg/dL in 255 days. Member #4025C9's Triglycerides moved from 119 to 76 mg/dL in 255 days.

Does Niacin change LDL cholesterol for APOE4 carriers?

Member #4025C9's LDL cholesterol moved from 135 to 121 mg/dL in 255 days. Support: 2 logged members, 2 members with repeats, 2 observations, 4 measurements.

Does Niacin change Total cholesterol for APOE4 carriers?

Member #4025C9's Total cholesterol moved from 239 to 205 mg/dL in 255 days. Support: 2 logged members, 2 members with repeats, 2 observations, 4 measurements.

Does Niacin change Triglycerides for APOE4 carriers?

Member #4025C9's Triglycerides moved from 119 to 76 mg/dL in 255 days. Support: 1 logged members, 1 members with repeats, 1 observations, 2 measurements.

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