One intervention, every measured benefit and result that did not improve. See who it moved for, where it stayed neutral or went the other way, and the next hypothesis Phoenix can validate.
Phoenix APOE4 Research · Reviewed by Kevin Tran, APOE4/4 carrier and founder · Data through 2026-08-23 · How to read this research
How to read this
Observational research: real APOE4 carriers tracked over time, each compared with their own earlier self. Members chose their interventions, with no randomisation or placebo group. Everything else they changed is shown beside each result.
Read the full methods and limitsPhoenix has measured Niacin against 3 exact outcomes for APOE4 carriers. Member #4025C9's LDL cholesterol moved from 135 to 121 mg/dL in 255 days. Member #4025C9's Total cholesterol moved from 239 to 205 mg/dL in 255 days. Member #4025C9's Triglycerides moved from 119 to 76 mg/dL in 255 days.
| Outcome | Direction | What we observed |
|---|---|---|
| LDL cholesterol | Repeated positive | Member #4025C9's LDL cholesterol moved from 135 to 121 mg/dL in 255 days. |
| Total cholesterol | Repeated positive | Member #4025C9's Total cholesterol moved from 239 to 205 mg/dL in 255 days. |
| Triglycerides | Positive individual result | Member #4025C9's Triglycerides moved from 119 to 76 mg/dL in 255 days. |
Phoenix has measured Niacin against 3 exact outcomes for APOE4 carriers. Member #4025C9's LDL cholesterol moved from 135 to 121 mg/dL in 255 days. Member #4025C9's Total cholesterol moved from 239 to 205 mg/dL in 255 days. Member #4025C9's Triglycerides moved from 119 to 76 mg/dL in 255 days.
Member #4025C9's LDL cholesterol moved from 135 to 121 mg/dL in 255 days. Support: 2 logged members, 2 members with repeats, 2 observations, 4 measurements.
Member #4025C9's Total cholesterol moved from 239 to 205 mg/dL in 255 days. Support: 2 logged members, 2 members with repeats, 2 observations, 4 measurements.
Member #4025C9's Triglycerides moved from 119 to 76 mg/dL in 255 days. Support: 1 logged members, 1 members with repeats, 1 observations, 2 measurements.
Search by health goal or intervention to see what changed for real members, including results that moved the wrong way.
Niacin · 3 outcomes shown.
LDL cholesterol: Decrease 12–14 mg/dL
Cases: 2Case range
Member #4025C9's LDL cholesterol moved from 135 to 121 mg/dL in 255 days.
Niacin
✓Repeated positiveMember #4025C9's LDL cholesterol moved from 135 to 121 mg/dL in 255 days.
LDL cholesterol
Before135After121mg/dL-10.4%
255 days between measurements
Full stack credited: Niacin (lead), Niacinamide (co), Curcumin (co), Turmeric (co).
What else changed: no nearby starts were recorded.
Next study: repeat LDL cholesterol after a dated Niacin window.
LDL cholesterol
Before114After102mg/dL-10.5%
110 days between measurements
Full stack credited: Niacinamide (lead), Curcumin (co).
What else changed: no nearby starts were recorded.
Next study: repeat LDL cholesterol after a dated Niacin window.
Total cholesterol: Decrease 15–34 mg/dL
Cases: 2Case range
Member #4025C9's Total cholesterol moved from 239 to 205 mg/dL in 255 days.
Niacin
✓Repeated positiveMember #4025C9's Total cholesterol moved from 239 to 205 mg/dL in 255 days.
Total cholesterol
Before239After205mg/dL-14.2%
255 days between measurements
Full stack credited: Niacin (lead), Niacinamide (co), Curcumin (co), Turmeric (co).
What else changed: no nearby starts were recorded.
Next study: repeat Total cholesterol after a dated Niacin window.
Total cholesterol
Before212After197mg/dL-7.1%
110 days between measurements
Full stack credited: Niacinamide (lead), Curcumin (co).
What else changed: no nearby starts were recorded.
Next study: repeat Total cholesterol after a dated Niacin window.
Triglycerides: Decrease 43 mg/dL
Cases: 1
Member #4025C9's Triglycerides moved from 119 to 76 mg/dL in 255 days.
Niacin
✓Positive individual resultMember #4025C9's Triglycerides moved from 119 to 76 mg/dL in 255 days.
Triglycerides
Before119After76mg/dL-36.1%
255 days between measurements
Full stack credited: Niacin (lead), Niacinamide (co), Omega-3 (co), Curcumin (co).
What else changed: no nearby starts were recorded.
Next study: repeat Triglycerides after a dated Niacin window.
The 43-page study: what members tried, how their bloodwork and wearable results changed, and what else changed alongside them.
Turn evidence into your next test
476 members have already tried, measured and logged. Join Phoenix and your next blood draw joins the same Navigator you are reading.
Full research index
Choose an outcome, like LDL cholesterol or sleep, or an intervention, like training: both paths open the same measured records.