Ranked only against the same measurement, in the same unit. See the positive, neutral, opposite-direction and still-collecting evidence before deciding what is worth your own test.
Observational research: real APOE4 carriers tracked over time, each compared with their own earlier self. Members chose their interventions, with no randomisation or placebo group. Everything else they changed is shown beside each result.
What can improve HDL cholesterol for APOE4 carriers?
For APOE4 carriers, Phoenix has published positive evidence for Estradiol patch, Ezetimibe, Plain omega-3, Statin family, and Estradiol vaginal against HDL cholesterol. Member #D9A2BF's HDL cholesterol moved from 32 to 41 mg/dL, about 28% higher, across six months. Member #6FAEFA's HDL cholesterol moved from 74 to 89 mg/dL in 70 days. Member #58A103's HDL cholesterol moved from 85 to 93 mg/dL in 118 days. Member #F111C1's HDL cholesterol moved from 36 to 43 mg/dL in 203 days. Member #EFF528's HDL cholesterol moved from 53 to 79 mg/dL in 338 days.
What has Phoenix measured against HDL cholesterol?
Phoenix has measured 5 interventions against HDL cholesterol: 5 positive. See the table below.
Every intervention measured against HDL cholesterol
Interventions measured against HDL cholesterol
Intervention
What we observed
Evidence status
Estradiol patch
Member #D9A2BF's HDL cholesterol moved from 32 to 41 mg/dL, about 28% higher, across six months.
Repeated positive
Ezetimibe
Member #6FAEFA's HDL cholesterol moved from 74 to 89 mg/dL in 70 days.
Repeated positive
Plain omega-3
Member #58A103's HDL cholesterol moved from 85 to 93 mg/dL in 118 days.
Repeated positive
Statin family
Member #F111C1's HDL cholesterol moved from 36 to 43 mg/dL in 203 days.
Repeated positive
Estradiol vaginal
Member #EFF528's HDL cholesterol moved from 53 to 79 mg/dL in 338 days.
Positive individual result
What changed for real APOE4 carriers?
Search by health goal or intervention to see what changed for real members, including results that moved the wrong way.
Health goalCholesterol and heart riskSubgoalImprove HDL cholesterol
Improve HDL cholesterol
Interventions tested: 7
Butyrate
SupplementsOutcomes: 1
HDL cholesterol:Increase 32.5 %32.5%
Cases: 1
Under review
Details
One curated butyrate case raised HDL cholesterol 32.5% in 85 days; paired values were not published.
Butyrate
?Collecting evidence
One curated butyrate case raised HDL cholesterol 32.5% in 85 days; paired values were not published.
Not explained by the science yetShort-chain fatty acid research on human metabolic outcomes is early and mostly preclinical; no established mechanism raises HDL from oral butyrate.
logged members
1
members with repeats
1
observations
1
measurements
2
Collecting evidence
No answer yet on HDL cholesterol
Butyrate is being tracked against HDL cholesterol, but Phoenix has not yet published a ranked result for this exact question.
Every carrier who logs a dated start and a repeat test moves this page closer to an answer, including you.
Follow Butyrate research.
Get an email when Phoenix publishes a meaningful update. At most one combined update each week.
This result is under review: Not printed as of Release 001: the published +32.5% HDL case could not be re-confirmed against the member it was attributed to in the 23-Aug data pull. Held pending a correct member match, not printed as a finding.
Member #D9A2BF's HDL cholesterol moved from 32 to 41 mg/dL, about 28% higher, across six months.
Estradiol patch
✓Repeated positive
Member #D9A2BF's HDL cholesterol moved from 32 to 41 mg/dL, about 28% higher, across six months.
Selected member cases
Phoenix memberAPOE4/457female
HDL cholesterol
Before46.4After59.2mg/dL+27.5%
292 days between measurements
Before46.4
After59.2
Consistent with established evidence
What else changed and what to test next
What else changed: no nearby starts were recorded.
Next study: One member raised HDL 28% and lowered triglycerides 37% on a confirmed estradiol patch start. Estrogen raising HDL is established; the patch route also avoids oral estrogens triglyceride-raising effect. The 42-member HRT cluster is the pool to confirm both markers.
Phoenix memberAPOE3/457female
HDL cholesterol
Before32After41mg/dL+28.1%
179 days between measurements
Before32
After41
Full stack credited: Estradiol patch (lead), Estradiol transdermal gel (co), Omega-3 (undated), Progesterone (co).
What else changed and what to test next
What else changed: no nearby starts were recorded.
Next study: One member raised HDL 28% and lowered triglycerides 37% on a confirmed estradiol patch start. Estrogen raising HDL is established; the patch route also avoids oral estrogens triglyceride-raising effect. The 42-member HRT cluster is the pool to confirm both markers.
logged members
35
members with repeats
2
observations
2
measurements
4
Not yet measured: how to test it
One member raised HDL 28% and lowered triglycerides 37% on a confirmed estradiol patch start. Estrogen raising HDL is established; the patch route also avoids oral estrogens triglyceride-raising effect. The 42-member HRT cluster is the pool to confirm both markers.
How to test it
Baseline
Blood draw before the dated estradiol start
Duration
90 days
Adherence
Confirmed active prescription for the full window
Retest
Repeat HDL cholesterol and triglycerides after at least 90 days
Falsifier
If 40 members with a dated estradiol start and repeat HDL and triglycerides show no consistent direction, the single-member result does not generalise to the HRT cluster.
One curated lithium-orotate case raised HDL cholesterol 24%; the report prints no paired values or elapsed days.
Lithium orotate
?Collecting evidence
One curated lithium-orotate case raised HDL cholesterol 24%; the report prints no paired values or elapsed days.
Not explained by the science yetLow-dose lithium orotate is a nutritional supplement with no established lipid mechanism; the psychiatric-dose lithium carbonate literature is a different drug and dose entirely.
logged members
77
members with repeats
1
observations
1
measurements
2
Collecting evidence
No answer yet on HDL cholesterol
Lithium orotate is being tracked against HDL cholesterol, but Phoenix has not yet published a ranked result for this exact question.
Every carrier who logs a dated start and a repeat test moves this page closer to an answer, including you.
Follow Lithium orotate research.
Get an email when Phoenix publishes a meaningful update. At most one combined update each week.
Context affected this result: Not printed as of Release 001: low-dose lithium orotate has no established lipid mechanism in humans, and it never leads a printed combination. It is not published as a driver.
Member #58A103's HDL cholesterol moved from 85 to 93 mg/dL in 118 days.
Plain omega-3
✓Repeated positive
Member #58A103's HDL cholesterol moved from 85 to 93 mg/dL in 118 days.
Selected member cases
Phoenix memberAPOE3/458female
HDL cholesterol
Before85After93mg/dL+9.4%
118 days between measurements
Before85
After93
What else changed and what to test next
What else changed: no nearby starts were recorded.
Next study: repeat HDL cholesterol after a dated Plain omega-3 window.
Phoenix memberAPOE4/451female
HDL cholesterol
Before61After74mg/dL+21.3%
191 days between measurements
Before61
After74
Mixed or inconclusive
Since this result, HDL swung to 57 mg/dL, below the original baseline, before recovering to 77 mg/dL. The two lowest readings came from one lab and the three highest from another, a lab-to-lab comparability question underneath the printed rise.
What else changed and what to test next
What else changed: no nearby starts were recorded.
Next study: repeat HDL cholesterol after a dated Plain omega-3 window.