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The APOE4 Carrier's First 7 Days
A calm, science-backed 7-day plan for the week after you find out: your genotype, the 5 systems it touches, a baseline lab plan, and a 90-day starting point.
Read the guideThe Essential Guide to Thriving with APOE4
The mechanism, then the no-regret interventions across nutrition, exercise, sleep, stress, supplements and toxins.
Read the guideThe APOE4 Woman's Guide
Estrogen and the brain, the HRT timing window, transdermal vs oral, and the honest state of the APOE4 + HRT evidence.
Read the guideBloodwork & biomarkers
The APOE4 Blood Work Blueprint
Evidence-based biomarker targets across 6 systems, a traffic-light scoring system, and a checklist for your doctor.
Read the guideThe APOE4 Brain Biomarker Guide
pTau-217, NfL, and GFAP: what a blood test can and cannot tell you, and a script for the conversation with your doctor.
Read the guideThe APOE4 Lipid Playbook
Why ApoB beats LDL, how the 90 / 70 / 60 cardiovascular risk tiers work, and the statin-vs-ezetimibe-vs-PCSK9 decision in plain English.
Read the guideThe APOE4 Metabolic Guide
Glucose, insulin, fasting, and GLP-1s: the brain-glucose gradient, whether a CGM is worth wearing, and the honest state of the GLP-1 and SGLT2 evidence.
Read the guideDaily protocol
The APOE4 Sleep & Glymphatic Protocol
The study that found better sleep blunted the APOE4 allele's effect on Alzheimer's risk, the brain's nightly wash cycle, and what the evidence does not support.
Read the guideThe APOE4 Diet Playbook
What to actually eat: Mediterranean vs. keto, red meat and dairy in context, the fiber lever that moves your ApoB, and a 90-day plate-building plan.
Read the guideThe APOE4 Exercise Protocol
Zone 2, HIIT read honestly, resistance training, and how muscle talks to your brain, built around the genotype question.
Read the guideThe APOE4 Inflammation, Gut & Stress Guide
Why APOE4 runs a hotter immune system, the gut-brain axis, cortisol and your hippocampus, and what to test and target.
Read the guideThe APOE4 Supplement Guide
What to take, what to skip, and how to pick a brand: the DHA-delivery problem, B-vitamins and homocysteine, vitamin D, creatine, and what the evidence does not support yet.
Read the guideThe APOE4 Optimizer's Stack
For carriers past the basics: the core lab panel, what a CGM actually proves, sleep stages and HRV decoded, and how to run your own N-of-1 experiment.
Read the guideThe APOE4 Emerging Therapies Watchlist
Anti-amyloid drugs, ARIA risk by genotype, gene therapy, and the rest of the pipeline, explained in plain English with the honest limits.
Read the guideThe APOE4 Thermal & Device Therapy Guide
Sauna, cold exposure, and red light are not equally proven: the evidence tier for each, the exact sauna dose, and the safety rules.
Read the guideFamily & doctors
APOE4 Genetic Testing & Family Guide
What one vs two copies means, 23andMe vs WGS vs clinical testing, GINA and insurance, and the family conversation.
Read the guideThe APOE4 Brief for Genetic Counselors
A peer-level clinical reference: lifetime-risk by genotype, REVEAL disclosure-safety, GINA, and cascade testing.
Read the guideThe Clinician's APOE4 Brief
For GPs, internists, neurologists, cardiologists, and gynaecologists: what to say in three minutes, what to measure, and the 2024 Lancet reframe.
Read the guideThe Doctor Conversation Kit
The six asks, the exact words, what not to request, and the GINA insurance trap, with a tear-out one-page brief for your doctor.
Read the guideThe Caregiver's 90-Day Plan
For the first three months after a parent or spouse is diagnosed: home safety, the medical team, the papers that cannot wait, and protecting your own brain too.
Read the guide