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Probiotics: what it changed, and what it did not

One intervention, every measured benefit and result that did not improve. See who it moved for, where it stayed neutral or went the other way, and the next hypothesis Phoenix can validate.

Phoenix APOE4 Research · Reviewed by Kevin Tran, APOE4/4 carrier and founder · Data through 2026-08-23 · How to read this research

How to read this

Observational research: real APOE4 carriers tracked over time, each compared with their own earlier self. Members chose their interventions, with no randomisation or placebo group. Everything else they changed is shown beside each result.

Read the full methods and limits

Key findings

Phoenix has measured Probiotics against 5 exact outcomes for APOE4 carriers. Member #1EB8E9's Apolipoprotein B moved from 122 to 94.1 mg/dL in 106 days. One curated Lactobacillus reuteri case lowered homocysteine 9.9%; the paired values were not published. Two probiotic strains in two clean curated cases lowered LDL cholesterol by 32.7% and 26.1%. Two curated probiotic cases lowered total cholesterol; one moved from 199 to 171 mg/dL and the other fell 17.7%. One clean curated case lowered triglycerides from 49 to 34 mg/dL in 59 days.

Probiotics evidence by outcome
OutcomeDirectionWhat we observed
Apolipoprotein BRepeated positiveMember #1EB8E9's Apolipoprotein B moved from 122 to 94.1 mg/dL in 106 days.
HomocysteinePositive individual resultOne curated Lactobacillus reuteri case lowered homocysteine 9.9%; the paired values were not published.
LDL cholesterolRepeated positiveTwo probiotic strains in two clean curated cases lowered LDL cholesterol by 32.7% and 26.1%.
Total cholesterolRepeated positiveTwo curated probiotic cases lowered total cholesterol; one moved from 199 to 171 mg/dL and the other fell 17.7%.
TriglyceridesPositive individual resultOne clean curated case lowered triglycerides from 49 to 34 mg/dL in 59 days.

Questions about Probiotics

What is the effect of Probiotics for APOE4 carriers?

Phoenix has measured Probiotics against 5 exact outcomes for APOE4 carriers. Member #1EB8E9's Apolipoprotein B moved from 122 to 94.1 mg/dL in 106 days. One curated Lactobacillus reuteri case lowered homocysteine 9.9%; the paired values were not published. Two probiotic strains in two clean curated cases lowered LDL cholesterol by 32.7% and 26.1%. Two curated probiotic cases lowered total cholesterol; one moved from 199 to 171 mg/dL and the other fell 17.7%. One clean curated case lowered triglycerides from 49 to 34 mg/dL in 59 days.

Does Probiotics change Apolipoprotein B for APOE4 carriers?

Member #1EB8E9's Apolipoprotein B moved from 122 to 94.1 mg/dL in 106 days. Support: 2 logged members, 2 members with repeats, 2 observations, 4 measurements.

Does Probiotics change Homocysteine for APOE4 carriers?

One curated Lactobacillus reuteri case lowered homocysteine 9.9%; the paired values were not published. Support: 1 observations, 2 measurements.

Does Probiotics change LDL cholesterol for APOE4 carriers?

Two probiotic strains in two clean curated cases lowered LDL cholesterol by 32.7% and 26.1%. Support: 2 observations, 4 measurements.

Does Probiotics change Total cholesterol for APOE4 carriers?

Two curated probiotic cases lowered total cholesterol; one moved from 199 to 171 mg/dL and the other fell 17.7%. Support: 2 observations, 4 measurements.

Does Probiotics change Triglycerides for APOE4 carriers?

One clean curated case lowered triglycerides from 49 to 34 mg/dL in 59 days. Support: 1 observations, 2 measurements.

What changed for real APOE4 carriers?

Search by health goal or intervention to see what changed for real members, including results that moved the wrong way.

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Probiotics · 5 outcomes shown.

Intervention categorySupplements
InterventionProbiotics

Probiotics

SupplementsOutcomes: 5

Apolipoprotein B: Decrease 25.2–27.9 mg/dL

Cases: 2Case range

Details

Member #1EB8E9's Apolipoprotein B moved from 122 to 94.1 mg/dL in 106 days.

Probiotics

✓Repeated positive

Member #1EB8E9's Apolipoprotein B moved from 122 to 94.1 mg/dL in 106 days.

Selected member cases

  1. Phoenix memberAPOE4/457female

    Apolipoprotein B

    Before135.2After110mg/dL-18.6%

    39 days between measurements

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat Apolipoprotein B after a dated Probiotics window.

  2. Phoenix memberAPOE4/457female

    Apolipoprotein B

    Before122After94.1mg/dL-22.9%

    106 days between measurements

    Full stack credited: Probiotics (lead), Bergamot (co).

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat Apolipoprotein B after a dated Probiotics window.

logged members
2
members with repeats
2
observations
2
measurements
4

Full record

Homocysteine: Decrease 9.9 %

Cases: 1

Details

One curated Lactobacillus reuteri case lowered homocysteine 9.9%; the paired values were not published.

Probiotics

✓Positive individual result

One curated Lactobacillus reuteri case lowered homocysteine 9.9%; the paired values were not published.

Little published human data on this link yet.

Selected member cases

  1. Phoenix member69female

    Homocysteine fell 9.9%; the public report does not print the paired values.

    Full stack credited: Folate (undated), Vitamin B12 (lead), B Complex (undated), Magnesium Glycinate (undated).

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat Homocysteine after a dated Probiotics window.

observations
1
measurements
2

Full record

LDL cholesterol: Decrease 32–41 mg/dL

Cases: 2Case range

Details

Two probiotic strains in two clean curated cases lowered LDL cholesterol by 32.7% and 26.1%.

Probiotics

✓Repeated positive

Two probiotic strains in two clean curated cases lowered LDL cholesterol by 32.7% and 26.1%.

Selected member cases

  1. Phoenix member69female

    LDL cholesterol

    Before157After116mg/dL-26.1%

    87 days between measurements

    Full stack credited: Bergamot (lead), Red yeast rice (undated), Curcumin (undated), Lactobacillus reuteri (co).

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: A human trial supports strain-specific LDL lowering, so Phoenix should record strain and dose rather than pool every probiotic.

  2. Phoenix memberAPOE3/448female

    LDL cholesterol

    Before98After66mg/dL-32.7%

    59 days between measurements

    Full stack credited: Statin (lead), Probiotics (co), Berberine (undated), Lysoveta (DHA-LPC) (undated).

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: A human trial supports strain-specific LDL lowering, so Phoenix should record strain and dose rather than pool every probiotic.

observations
2
measurements
4
Not yet measured: how to test it

A human trial supports strain-specific LDL lowering, so Phoenix should record strain and dose rather than pool every probiotic.

How to test it

Baseline
Record LDL cholesterol before the dated probiotic start.
Duration
84 days
Adherence
Record strain, dose and adherence throughout the window.
Retest
Repeat LDL cholesterol after 12 weeks.
Falsifier
A predeclared strain-specific cohort does not reproduce lower LDL cholesterol.
Eligible-member target
40 members

Full record

Total cholesterol: Decrease 28 mg/dL

Cases: 2

Details

Two curated probiotic cases lowered total cholesterol; one moved from 199 to 171 mg/dL and the other fell 17.7%.

Probiotics

✓Repeated positive

Two curated probiotic cases lowered total cholesterol; one moved from 199 to 171 mg/dL and the other fell 17.7%.

Selected member cases

  1. Phoenix member69female

    Total cholesterol fell 17.7%; the public report does not print the paired values.

    Full stack credited: Bergamot (lead), Red yeast rice (undated), Curcumin (undated), Lactobacillus reuteri (co).

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat Total cholesterol after a dated Probiotics window.

  2. Phoenix memberAPOE3/448female

    Total cholesterol

    Before199After171mg/dL-14.1%

    59 days between measurements

    Full stack credited: Statin (lead), Probiotics (co), Berberine (undated), Lysoveta (DHA-LPC) (undated).

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat Total cholesterol after a dated Probiotics window.

observations
2
measurements
4

Full record

Triglycerides: Decrease 15 mg/dL

Cases: 1

Details

One clean curated case lowered triglycerides from 49 to 34 mg/dL in 59 days.

Probiotics

✓Positive individual result

One clean curated case lowered triglycerides from 49 to 34 mg/dL in 59 days.

Little published human data on this link yet.

Selected member cases

  1. Phoenix memberAPOE3/448female

    Triglycerides

    Before49After34mg/dL-30.6%

    59 days between measurements

    Full stack credited: Statin (lead), Probiotics (co), Berberine (undated), Lysoveta (DHA-LPC) (undated).

    What else changed and what to test next

    What else changed: no nearby starts were recorded.

    Next study: repeat Triglycerides after a dated Probiotics window.

observations
1
measurements
2

Full record

The Beat the Odds Study

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