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Apolipoprotein B: every measured intervention

Ranked only against the same measurement, in the same unit. See the positive, neutral, opposite-direction and still-collecting evidence before deciding what is worth your own test.

Phoenix APOE4 Research · Reviewed by Kevin Tran, APOE4/4 carrier and founder · Data through 2026-08-23 · How to read this research

How to read this

Observational research: real APOE4 carriers tracked over time, each compared with their own earlier self. Members chose their interventions, with no randomisation or placebo group. Everything else they changed is shown beside each result.

Read the full methods and limits

Questions about Apolipoprotein B

What can improve Apolipoprotein B for APOE4 carriers?

For APOE4 carriers, Phoenix has published positive evidence for Ezetimibe, Probiotics, Statin family, and Psyllium against Apolipoprotein B. Member #29E727 lowered ApoB from 131 to 90 mg/dL in 133 days on an ezetimibe-led combination. Member #1EB8E9's Apolipoprotein B moved from 122 to 94.1 mg/dL in 106 days. Member #5AA27F lowered ApoB from 98 to 59 mg/dL in 77 days; generic and named statin use counts are not summed. Member #61477B's Apolipoprotein B moved from 107 to 95 mg/dL in 115 days.

What has Phoenix measured against Apolipoprotein B?

Phoenix has measured 4 interventions against Apolipoprotein B: 4 positive. See the table below.

Every intervention measured against Apolipoprotein B

Interventions measured against Apolipoprotein B
Intervention	What we observed	Evidence status
Ezetimibe	Member #29E727 lowered ApoB from 131 to 90 mg/dL in 133 days on an ezetimibe-led combination.	Repeated positive
Probiotics	Member #1EB8E9's Apolipoprotein B moved from 122 to 94.1 mg/dL in 106 days.	Repeated positive
Statin family	Member #5AA27F lowered ApoB from 98 to 59 mg/dL in 77 days; generic and named statin use counts are not summed.	Repeated positive
Psyllium	Member #61477B's Apolipoprotein B moved from 107 to 95 mg/dL in 115 days.	Positive individual result

Cholesterol and heart risk · Lower ApoB · 5 interventions shown.

Health goalCholesterol and heart risk

SubgoalLower ApoB

Lower ApoB

Interventions tested: 5

Ezetimibe

MedicationsOutcomes: 1

Apolipoprotein B: Decrease 36–41 mg/dL

Cases: 2Case range

Details

Member #29E727 lowered ApoB from 131 to 90 mg/dL in 133 days on an ezetimibe-led combination.

Ezetimibe

✓Repeated positive

Member #29E727 lowered ApoB from 131 to 90 mg/dL in 133 days on an ezetimibe-led combination.

Selected member cases

Phoenix memberAPOE4/467female
Apolipoprotein B
Before131After90mg/dL-31.3%
133 days between measurements
Full stack credited: Ezetimibe (lead), Psyllium (co).
What else changed and what to test next
What else changed: no nearby starts were recorded.
Next study: repeat Apolipoprotein B after a dated Ezetimibe window.
Phoenix memberAPOE3/451female
Apolipoprotein B
Before147After111mg/dL-24.5%
207 days between measurements
Full stack credited: Ezetimibe (lead), Berberine (co).
What else changed and what to test next
What else changed: no nearby starts were recorded.
Next study: repeat Apolipoprotein B after a dated Ezetimibe window.

logged members: 2
members with repeats: 2
observations: 2
measurements: 4

Full record

Probiotics

SupplementsOutcomes: 1

Apolipoprotein B: Decrease 25.2–27.9 mg/dL

Cases: 2Case range

Details

Member #1EB8E9's Apolipoprotein B moved from 122 to 94.1 mg/dL in 106 days.

Probiotics

✓Repeated positive

Member #1EB8E9's Apolipoprotein B moved from 122 to 94.1 mg/dL in 106 days.

Selected member cases

Phoenix memberAPOE4/457female
Apolipoprotein B
Before135.2After110mg/dL-18.6%
39 days between measurements
What else changed and what to test next
What else changed: no nearby starts were recorded.
Next study: repeat Apolipoprotein B after a dated Probiotics window.
Phoenix memberAPOE4/457female
Apolipoprotein B
Before122After94.1mg/dL-22.9%
106 days between measurements
Full stack credited: Probiotics (lead), Bergamot (co).
What else changed and what to test next
What else changed: no nearby starts were recorded.
Next study: repeat Apolipoprotein B after a dated Probiotics window.

logged members: 2
members with repeats: 2
observations: 2
measurements: 4

Full record

Psyllium

SupplementsOutcomes: 1

Apolipoprotein B: Decrease 12 mg/dL

Cases: 1

Details

Member #61477B's Apolipoprotein B moved from 107 to 95 mg/dL in 115 days.

Psyllium

✓Positive individual result

Member #61477B's Apolipoprotein B moved from 107 to 95 mg/dL in 115 days.

Selected member cases

Phoenix memberAPOE4/464female
Apolipoprotein B
Before107After95mg/dL-11.2%
115 days between measurements
Mixed or inconclusive
Full stack credited: Psyllium (lead), Omega-3 (co).
Since this result, ApoB was unchanged at the next draw, then climbed back to 104 mg/dL, close to the 107 mg/dL starting point, in the draw closest to Phoenix's data freeze.
What else changed and what to test next
What else changed: no nearby starts were recorded.
Next study: repeat Apolipoprotein B after a dated Psyllium window.

logged members: 1
members with repeats: 1
observations: 1
measurements: 2

Full record

Statin family

MedicationsOutcomes: 1

Apolipoprotein B: Decrease 8–39 mg/dL

Cases: 2Case range

Details

Member #5AA27F lowered ApoB from 98 to 59 mg/dL in 77 days; generic and named statin use counts are not summed.

Statin family

✓Repeated positive

Member #5AA27F lowered ApoB from 98 to 59 mg/dL in 77 days; generic and named statin use counts are not summed.

Selected member cases

Phoenix memberAPOE3/462female
Apolipoprotein B
Before98After59mg/dL-39.8%
112 days between measurements
Full stack credited: Statin (lead), Citicoline (co).
What else changed and what to test next
What else changed: no nearby starts were recorded.
Next study: repeat Apolipoprotein B after a dated Statin family window.
Phoenix memberAPOE4/454male
Apolipoprotein B
Before69After61mg/dL-11.6%
203 days between measurements
Full stack credited: Statin (lead), Probiotics (co).
What else changed and what to test next
What else changed: no nearby starts were recorded.
Next study: repeat Apolipoprotein B after a dated Statin family window.

logged members: 2
members with repeats: 2
observations: 2
measurements: 4

Full record

Vitamin C

SupplementsOutcomes: 1

Apolipoprotein B: Decrease 18.5 %

Cases: 1

Context affected

Details

Member #1EB8E9's ApoB moved from 135 to 110 mg/dL in 39 days; deterministic arithmetic gives a reduction of 18.5%.

Vitamin C

?Collecting evidence

Member #1EB8E9's ApoB moved from 135 to 110 mg/dL in 39 days; deterministic arithmetic gives a reduction of 18.5%.

Not explained by the science yetVitamin C has no established mechanism for lowering ApoB particle count, and human RCTs on vitamin C and lipids are mostly null or mixed.

observations: 1
measurements: 2

Collecting evidence

No answer yet on Apolipoprotein B

Vitamin C is being tracked against Apolipoprotein B, but Phoenix has not yet published a ranked result for this exact question.

Every carrier who logs a dated start and a repeat test moves this page closer to an answer, including you.

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Context affected this result: Not printed as of Release 001: no ApoB-lowering mechanism for vitamin C, and the member's window carries six simultaneous starts with a real statin-class rival (rosuvastatin). This case is not included in the printed cases or test-next list.

Full record

The Beat the Odds Study

The 43-page study: what members tried, how their bloodwork and wearable results changed, and what else changed alongside them.

Download the Beat the Odds Study

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