Ranked only against the same measurement, in the same unit. See the positive, neutral, opposite-direction and still-collecting evidence before deciding what is worth your own test.
Phoenix APOE4 Research · Reviewed by Kevin Tran, APOE4/4 carrier and founder · Data through 2026-08-23 · How to read this research
How to read this
Observational research: real APOE4 carriers tracked over time, each compared with their own earlier self. Members chose their interventions, with no randomisation or placebo group. Everything else they changed is shown beside each result.
Read the full methods and limitsFor APOE4 carriers, Phoenix has published positive evidence for CoQ10 / ubiquinol, Magnesium glycinate, Metformin, and Estradiol patch against Glucose. Member #B8D290's Glucose moved from 100 to 92 mg/dL in 174 days. Member #EFF528's Glucose moved from 97 to 88 mg/dL in 338 days. Member #2351C3's Glucose moved from 114 to 88 mg/dL in 718 days. Member #FBD61B's Glucose moved from 90.091 to 73.3341 mg/dL in 292 days.
Phoenix has measured 4 interventions against Glucose: 4 positive. See the table below.
| Intervention | What we observed | Evidence status |
|---|---|---|
| CoQ10 / ubiquinol | Member #B8D290's Glucose moved from 100 to 92 mg/dL in 174 days. | Repeated positive |
| Magnesium glycinate | Member #EFF528's Glucose moved from 97 to 88 mg/dL in 338 days. | Repeated positive |
| Metformin | Member #2351C3's Glucose moved from 114 to 88 mg/dL in 718 days. | Positive individual result |
| Estradiol patch | Member #FBD61B's Glucose moved from 90.091 to 73.3341 mg/dL in 292 days. | Positive individual result |
Search by health goal or intervention to see what changed for real members, including results that moved the wrong way.
Blood sugar · Improve glucose · 4 interventions shown.
Glucose: Decrease 8 mg/dL
Cases: 2Case range
Member #B8D290's Glucose moved from 100 to 92 mg/dL in 174 days.
CoQ10 / ubiquinol
✓Repeated positiveMember #B8D290's Glucose moved from 100 to 92 mg/dL in 174 days.
Glucose
Before89After81mg/dL-9%
77 days between measurements
Full stack credited: Magnesium Glycinate (undated), CoQ10 (lead).
What else changed: no nearby starts were recorded.
Next study: repeat Glucose after a dated CoQ10 / ubiquinol window.
Glucose
Before100After92mg/dL-8%
174 days between measurements
What else changed: no nearby starts were recorded.
Next study: repeat Glucose after a dated CoQ10 / ubiquinol window.
Glucose: Decrease 16.8 mg/dL
Cases: 1
Member #FBD61B's Glucose moved from 90.091 to 73.3341 mg/dL in 292 days.
Estradiol patch
✓Positive individual resultMember #FBD61B's Glucose moved from 90.091 to 73.3341 mg/dL in 292 days.
Glucose
Before90.1After73.3mg/dL-18.6%
292 days between measurements
Full stack credited: Estradiol transdermal gel (lead), Tirzepatide (undated).
What else changed: no nearby starts were recorded.
Next study: repeat Glucose after a dated Estradiol patch window.
Glucose: Decrease 7–13.7 mg/dL
Cases: 4Case range
Member #EFF528's Glucose moved from 97 to 88 mg/dL in 338 days.
Magnesium glycinate
✓Repeated positiveMember #EFF528's Glucose moved from 97 to 88 mg/dL in 338 days.
Glucose
Before86After76mg/dL-11.6%
110 days between measurements
Mixed or inconclusive
Full stack credited: Magnesium Glycinate (lead), CoQ10 (co).
Since this result, glucose climbed back to 86 mg/dL and then 89 mg/dL, at or above the original starting point, in the draws closest to Phoenix's data freeze. The printed drop reflects a single low reading that did not hold.
What else changed: no nearby starts were recorded.
Next study: repeat Glucose after a dated Magnesium glycinate window.
Glucose
Before97After88mg/dL-9.3%
338 days between measurements
What else changed: no nearby starts were recorded.
Next study: repeat Glucose after a dated Magnesium glycinate window.
Glucose
Before98.7After85mg/dL-13.9%
70 days between measurements
Full stack credited: Magnesium Glycinate (lead), Tirzepatide (co).
What else changed: no nearby starts were recorded.
Next study: repeat Glucose after a dated Magnesium glycinate window.
Glucose
Before87After80mg/dL-8%
68 days between measurements
Full stack credited: Magnesium Glycinate (undated), CoQ10 (lead), Ubiquinol (undated).
What else changed: no nearby starts were recorded.
Next study: repeat Glucose after a dated Magnesium glycinate window.
Glucose: Decrease 26 mg/dL
Cases: 1
Member #2351C3's Glucose moved from 114 to 88 mg/dL in 718 days.
Metformin
✓Positive individual resultMember #2351C3's Glucose moved from 114 to 88 mg/dL in 718 days.
Glucose
Before114After88mg/dL-22.8%
718 days between measurements
What else changed: no nearby starts were recorded.
Next study: repeat Glucose after a dated Metformin window.
The 43-page study: what members tried, how their bloodwork and wearable results changed, and what else changed alongside them.
Turn evidence into your next test
476 members have already tried, measured and logged. Join Phoenix and your next blood draw joins the same Navigator you are reading.
Full research index
Choose an outcome, like LDL cholesterol or sleep, or an intervention, like training: both paths open the same measured records.