Ranked only against the same measurement, in the same unit. See the positive, neutral, opposite-direction and still-collecting evidence before deciding what is worth your own test.
Phoenix APOE4 Research · Reviewed by Kevin Tran, APOE4/4 carrier and founder · Data through 2026-08-23 · How to read this research
How to read this
Observational research: real APOE4 carriers tracked over time, each compared with their own earlier self. Members chose their interventions, with no randomisation or placebo group. Everything else they changed is shown beside each result.
Read the full methods and limitsFor APOE4 carriers, Phoenix has published positive evidence for Berberine, Metformin, and Tirzepatide against Insulin. Member #EFF528's Insulin moved from 2.3 to 2.1 uIU/mL in 207 days. Member #15000A lowered fasting insulin from 12.6 to 6.5 uIU/mL in 162 days on metformin and tirzepatide, both undated. Member #6FAEFA's Insulin moved from 6.3 to 4.2 uIU/mL in 70 days.
Phoenix has measured 3 interventions against Insulin: 3 positive. See the table below.
| Intervention | What we observed | Evidence status |
|---|---|---|
| Berberine | Member #EFF528's Insulin moved from 2.3 to 2.1 uIU/mL in 207 days. | Positive individual result |
| Metformin | Member #15000A lowered fasting insulin from 12.6 to 6.5 uIU/mL in 162 days on metformin and tirzepatide, both undated. | Positive individual result |
| Tirzepatide | Member #6FAEFA's Insulin moved from 6.3 to 4.2 uIU/mL in 70 days. | Positive individual result |
Search by health goal or intervention to see what changed for real members, including results that moved the wrong way.
Blood sugar · Improve insulin · 3 interventions shown.
Insulin: Decrease 0.2 uIU/mL
Cases: 1
Member #EFF528's Insulin moved from 2.3 to 2.1 uIU/mL in 207 days.
Berberine
✓Positive individual resultMember #EFF528's Insulin moved from 2.3 to 2.1 uIU/mL in 207 days.
Insulin
Before2.3After2.1uIU/mL-8.7%
207 days between measurements
What else changed: no nearby starts were recorded.
Next study: repeat Insulin after a dated Berberine window.
Insulin: Decrease 6.1 uIU/mL
Cases: 1
Member #15000A lowered fasting insulin from 12.6 to 6.5 uIU/mL in 162 days on metformin and tirzepatide, both undated.
Metformin
✓Positive individual resultMember #15000A lowered fasting insulin from 12.6 to 6.5 uIU/mL in 162 days on metformin and tirzepatide, both undated.
Insulin
Before12.6After6.5uIU/mL-48.4%
162 days between measurements
Full stack credited: Metformin (lead), Tirzepatide (undated).
What else changed: no nearby starts were recorded.
Next study: repeat Insulin after a dated Metformin window.
Insulin: Decrease 2.1 uIU/mL
Cases: 1
Member #6FAEFA's Insulin moved from 6.3 to 4.2 uIU/mL in 70 days.
Tirzepatide
✓Positive individual resultMember #6FAEFA's Insulin moved from 6.3 to 4.2 uIU/mL in 70 days.
Insulin
Before6.3After4.2uIU/mL-33.3%
70 days between measurements
What else changed: no nearby starts were recorded.
Next study: repeat Insulin after a dated Tirzepatide window.
The 43-page study: what members tried, how their bloodwork and wearable results changed, and what else changed alongside them.
Turn evidence into your next test
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Choose an outcome, like LDL cholesterol or sleep, or an intervention, like training: both paths open the same measured records.