Browse by health goal

Cholesterol and heart risk: what moved for Phoenix members

Keep LDL, ApoB, HDL, triglycerides and other lipid outcomes separate. Compare the interventions attached to each exact measurement before choosing what to test in yourself.

Research issue
Issue 01
Data through
2026-08-09
Evidence map version
v1.1.0
Explore the evidence Get the Evidence Map

How to read this

Phoenix research is longitudinal and observational: we follow real APOE4 carriers over time and compare each member with their own earlier self, with no placebo group, no randomisation, and members choosing their own interventions.

That means these are strong signals pointing at what to test next, not proof of cause. Most nutrition, supplement and lifestyle research you read online has exactly the same design. The difference is that we say so, and we show you the confounders.

Read the full methods and limits

What the Phoenix community is measuring

Browse exact outcomes and interventions. Each result keeps its source, measurement rule and audit record beside the claim.

Get the PDFJoin Phoenix in 7 minutes Open inside Phoenix

Cholesterol and heart risk

Keep LDL, ApoB, HDL, triglycerides and other lipid outcomes separate.

Most promising

Apolipoprotein B

Laboratory apolipoprotein B result · Aim: lower

Creatine monohydrate

✓Positive individual result

The Fine Tuner later recorded a clean 12.3% ApoB reduction; Issue 01 does not print the paired values or elapsed days.

Selected member cases

  1. Fine Tuner · APOE3/4 · female · age 50-59

    ApoB fell 12.3% in a later clean creatine window; paired values and elapsed days were not printed.

    What else changed: no nearby starts were recorded.

    Next study: repeat Apolipoprotein B after a dated Creatine monohydrate window.

1 selected member case · not a response rate

Logged members
119
Members with repeats
1
Observations
1
Measurements
2
Sources and context

Members with a logged creatine start and repeat ApoB result; the visible case is curated.

  • report-lines-248-343, reviewed by independent verifier

1 selected case shown with this evidence.

Statin family

✓Positive individual result

The ApoB Ace lowered ApoB from 98 to 59 mg/dL in 77 days; generic and named statin use counts are not summed.

Selected member cases

  1. ApoB Ace · APOE3/4 · female · age 60-69

    98 → 59 mg/dL · -39.8% · 77 days

    What else changed: no nearby starts were recorded.

    Next study: repeat Apolipoprotein B after a dated Statin family window.

1 selected member case · not a response rate

Logged members
1
Members with repeats
1
Observations
1
Measurements
2
Sources and context

Curated statin-family cases with a dated start and repeat ApoB result.

  • report-lines-215-245, reviewed by independent verifier

1 selected case shown with this evidence.

Vitamin C

✓Positive individual result

The Monthly Retester's ApoB moved from 135 to 110 mg/dL in 39 days; deterministic arithmetic gives a reduction of 18.5%.

Selected member cases

  1. Monthly Retester · APOE4/4 · female · age 50-59

    135 → 110 mg/dL · -18.5% · 39 days

    What else changed: no nearby starts were recorded.

    Next study: Human trial synthesis did not establish an overall lipid effect or ApoB result, so the Phoenix case needs replication.

1 selected member case · not a response rate

Observations
1
Measurements
2
Sources and context

Members with a logged vitamin C start and repeat ApoB result; the visible case is curated.

  • report-lines-248-343, reviewed by independent verifier

1 selected case shown with this evidence.

Not yet measured

Human trial synthesis did not establish an overall lipid effect or ApoB result, so the Phoenix case needs replication.

How to test it

Baseline
Record ApoB before the dated vitamin C start.
Duration
84 days
Adherence
Record dose and adherence throughout the window.
Retest
Repeat ApoB after 12 weeks.
Falsifier
Clean vitamin C windows do not reproduce lower ApoB.
Eligible-member target
40 members

HDL cholesterol

Laboratory HDL cholesterol result · Aim: higher

Lysoveta DHA-LPC

✓Repeated positive

Two clean curated cases raised HDL cholesterol by 18.7% and 11.5%; external literature does not establish this Lysoveta lipid effect.

Selected member cases

  1. Lysoveta HDL case two · genotype not disclosed · female · age not disclosed

    HDL cholesterol rose 11.5% in a second clean window; paired values and elapsed days were not printed.

    What else changed: no nearby starts were recorded.

    Next study: repeat HDL cholesterol after a dated Lysoveta DHA-LPC window.

  2. Omega Lifter · APOE4/4 · male · age 40-49

    61.5 → 73 mg/dL · +18.7% · 67 days

    What else changed: no nearby starts were recorded.

    Next study: repeat HDL cholesterol after a dated Lysoveta DHA-LPC window.

2 selected member cases · not a response rate

Logged members
2
Members with repeats
2
Observations
2
Measurements
4
Sources and context

Members with a logged Lysoveta start and repeat HDL cholesterol result; visible cases are curated.

  • report-lines-248-343, reviewed by independent verifier

2 selected cases shown with this evidence.

Butyrate

✓Positive individual result

One curated butyrate case raised HDL cholesterol 32.5% in 85 days; paired values were not published.

Selected member cases

  1. Butyrate HDL case · APOE4/4 · female · age 50-59

    HDL cholesterol rose 32.5% in an 85-day clean window; paired values were not printed.

    What else changed: no nearby starts were recorded.

    Next study: repeat HDL cholesterol after a dated Butyrate window.

1 selected member case · not a response rate

Logged members
1
Members with repeats
1
Observations
1
Measurements
2
Sources and context

Members with a logged butyrate start and repeat HDL cholesterol result; the visible case is curated.

  • report-lines-248-343, reviewed by independent verifier

1 selected case shown with this evidence.

Estradiol patch

✓Positive individual result

The Night Shift's HDL cholesterol moved from 32 to 41 mg/dL, about 28% higher, across six months.

Selected member cases

  1. Night Shift · APOE3/4 · female · age 50-59

    HDL cholesterol rose from 32 to 41 mg/dL across six months; exact elapsed days were not printed.

    What else changed: no nearby starts were recorded.

    Next study: repeat HDL cholesterol after a dated Estradiol patch window.

1 selected member case · not a response rate

Logged members
34
Members with repeats
1
Observations
1
Measurements
2
Sources and context

Curated estradiol-patch cases with repeat HDL cholesterol; broader estradiol-form users are support context only.

  • report-lines-215-245, reviewed by independent verifier

1 selected case shown with this evidence.

Lithium orotate

✓Positive individual result

One curated lithium-orotate case raised HDL cholesterol 24%; the report prints no paired values or elapsed days.

Selected member cases

  1. Lithium HDL case · genotype not disclosed · sex not disclosed · age not disclosed

    HDL cholesterol rose 24%; paired values and elapsed days were not printed.

    What else changed: no nearby starts were recorded.

    Next study: repeat HDL cholesterol after a dated Lithium orotate window.

1 selected member case · not a response rate

Logged members
77
Members with repeats
1
Observations
1
Measurements
2
Sources and context

Curated lithium-orotate cases with a named repeat lipid outcome.

  • report-lines-248-343, reviewed by independent verifier

1 selected case shown with this evidence.

LDL cholesterol

Laboratory LDL cholesterol result · Aim: lower

Probiotics

✓Repeated positive

Two probiotic strains in two clean curated cases lowered LDL cholesterol by 32.7% and 26.1%.

Selected member cases

  1. Probiotic Repeat · genotype not disclosed · female · age 60-69

    157 → 116 mg/dL · -26.1% · 87 days

    What else changed: no nearby starts were recorded.

    Next study: A human trial supports strain-specific LDL lowering, so Phoenix should record strain and dose rather than pool every probiotic.

  2. Triple Mover · APOE3/4 · female · age 40-49

    98 → 66 mg/dL · -32.7% · 56 days

    What else changed: no nearby starts were recorded.

    Next study: A human trial supports strain-specific LDL lowering, so Phoenix should record strain and dose rather than pool every probiotic.

2 selected member cases · not a response rate

Observations
2
Measurements
4
Sources and context

Members with a logged probiotic and repeat LDL result; the public cases are curated rather than exhaustive.

  • report-lines-248-343, reviewed by independent verifier

2 selected cases shown with this evidence.

Not yet measured

A human trial supports strain-specific LDL lowering, so Phoenix should record strain and dose rather than pool every probiotic.

How to test it

Baseline
Record LDL cholesterol before the dated probiotic start.
Duration
84 days
Adherence
Record strain, dose and adherence throughout the window.
Retest
Repeat LDL cholesterol after 12 weeks.
Falsifier
A predeclared strain-specific cohort does not reproduce lower LDL cholesterol.
Eligible-member target
40 members

Creatine monohydrate

✓Positive individual result

One clean curated case lowered LDL cholesterol from 104 to 67 mg/dL in 83 days; an unscoped flat creatine result is not classified as LDL-neutral.

Selected member cases

  1. Fine Tuner · APOE3/4 · female · age 50-59

    104 → 67 mg/dL · -35.6% · 83 days

    What else changed: no nearby starts were recorded.

    Next study: Human trials leave a null result plausible, so the Phoenix case needs a predeclared replication rather than a mechanism claim.

1 selected member case · not a response rate

Logged members
119
Members with repeats
59
Observations
1
Measurements
2
Sources and context

Creatine-family users with repeat LDL results provide support context; clean eligibility was not exhaustively published.

  • report-lines-248-343, reviewed by independent verifier
  • report-lines-129-156, reviewed by independent verifier

1 selected case shown with this evidence.

Not yet measured

Human trials leave a null result plausible, so the Phoenix case needs a predeclared replication rather than a mechanism claim.

How to test it

Baseline
Record LDL cholesterol before the dated creatine start.
Duration
84 days
Adherence
Record dose and adherence throughout the window.
Retest
Repeat LDL cholesterol after 12 weeks.
Falsifier
Clean creatine windows do not reproduce lower LDL cholesterol under a predeclared analysis.
Eligible-member target
40 members

Lithium orotate

✓Positive individual result

One curated lithium-orotate case lowered LDL cholesterol 15%; the report prints no paired values or elapsed days.

Selected member cases

  1. Lithium LDL case · genotype not disclosed · sex not disclosed · age not disclosed

    LDL cholesterol fell 15%; paired values and elapsed days were not printed.

    What else changed: no nearby starts were recorded.

    Next study: repeat LDL cholesterol after a dated Lithium orotate window.

1 selected member case · not a response rate

Logged members
77
Members with repeats
1
Observations
1
Measurements
2
Sources and context

Curated lithium-orotate cases with a named repeat lipid outcome.

  • report-lines-248-343, reviewed by independent verifier

1 selected case shown with this evidence.

Lysoveta DHA-LPC

✓Positive individual result

The Omega Lifter later recorded LDL cholesterol moving from 139 to 93 mg/dL, down 33.1%; elapsed days were not published.

Selected member cases

  1. Omega Lifter · APOE4/4 · male · age 40-49

    LDL cholesterol fell from 139 to 93 mg/dL, down 33.1%; elapsed days were not printed.

    What else changed: no nearby starts were recorded.

    Next study: repeat LDL cholesterol after a dated Lysoveta DHA-LPC window.

1 selected member case · not a response rate

Logged members
1
Members with repeats
1
Observations
1
Measurements
2
Sources and context

Members with a logged Lysoveta start and repeat LDL cholesterol result; the visible case is curated.

  • report-lines-248-343, reviewed by independent verifier

1 selected case shown with this evidence.

NMN

✓Positive individual result

One clean curated NMN case lowered LDL cholesterol 26.3% in 42 days; paired values were not published.

Selected member cases

  1. NMN LDL case · APOE3/4 · female · age 50-59

    LDL cholesterol fell 26.3% in a 42-day clean window; paired values were not printed.

    What else changed: no nearby starts were recorded.

    Next study: A small short product-specific human trial provides preliminary context, not a general NMN lipid verdict.

1 selected member case · not a response rate

Logged members
1
Members with repeats
1
Observations
1
Measurements
2
Sources and context

Members with a logged NMN start and repeat LDL result; the visible case is curated.

  • report-lines-248-343, reviewed by independent verifier

1 selected case shown with this evidence.

Not yet measured

A small short product-specific human trial provides preliminary context, not a general NMN lipid verdict.

How to test it

Baseline
Record LDL cholesterol before the dated NMN start.
Duration
84 days
Adherence
Record product, dose and adherence throughout the window.
Retest
Repeat LDL cholesterol after 12 weeks.
Falsifier
Clean NMN windows do not reproduce lower LDL cholesterol.
Eligible-member target
40 members

Plain omega-3

✓Positive individual result

The Long Gamer's LDL cholesterol moved from 129 to 99 mg/dL, down 23.3%, across a one-year clean window.

Selected member cases

  1. Long Gamer · APOE4/4 · male · age 60-69

    LDL cholesterol fell from 129 to 99 mg/dL, down 23.3%, across a one-year clean window.

    What else changed: no nearby starts were recorded.

    Next study: repeat LDL cholesterol after a dated Plain omega-3 window.

1 selected member case · not a response rate

Logged members
156
Members with repeats
1
Observations
1
Measurements
2
Sources and context

Members with plain omega-3 exposure and repeat LDL cholesterol; the visible case is curated.

  • report-lines-248-343, reviewed by independent verifier

1 selected case shown with this evidence.

Statin family

✓Positive individual result

The ApoB Ace's longer arc moved LDL cholesterol from 161 to 49 mg/dL, about 70% lower; the aggregate statin effect remains unresolved.

Selected member cases

  1. ApoB Ace · APOE3/4 · female · age 60-69

    LDL cholesterol fell from 161 to 49 mg/dL across nearly one year; exact elapsed days were not printed.

    What else changed: no nearby starts were recorded.

    Next study: repeat LDL cholesterol after a dated Statin family window.

1 selected member case · not a response rate

Logged members
1
Members with repeats
1
Observations
1
Measurements
2
Sources and context

Curated statin-family cases with repeat LDL cholesterol; overlapping catalogue use counts and aggregate cohorts are excluded.

  • report-lines-215-245, reviewed by independent verifier

1 selected case shown with this evidence.

Total cholesterol

Laboratory total cholesterol result · Aim: lower

Probiotics

✓Repeated positive

Two curated probiotic cases lowered total cholesterol; one moved from 199 to 171 mg/dL and the other fell 17.7%.

Selected member cases

  1. Probiotic Repeat · genotype not disclosed · female · age 60-69

    Total cholesterol fell 17.7%; the public report does not print the paired values.

    What else changed: no nearby starts were recorded.

    Next study: repeat Total cholesterol after a dated Probiotics window.

  2. Triple Mover · APOE3/4 · female · age 40-49

    199 → 171 mg/dL · -14.1% · 56 days

    What else changed: no nearby starts were recorded.

    Next study: repeat Total cholesterol after a dated Probiotics window.

2 selected member cases · not a response rate

Observations
2
Measurements
4
Sources and context

Members with a logged probiotic and repeat total cholesterol result; the visible cases are curated.

  • report-lines-248-343, reviewed by independent verifier

2 selected cases shown with this evidence.

Statin family

✓Positive individual result

The ApoB Ace's total cholesterol fell 41.6% in the longer statin arc; paired values and exact elapsed days were not printed.

Selected member cases

  1. ApoB Ace · APOE3/4 · female · age 60-69

    Total cholesterol fell 41.6% in the longer statin arc; paired values and exact elapsed days were not printed.

    What else changed: no nearby starts were recorded.

    Next study: repeat Total cholesterol after a dated Statin family window.

1 selected member case · not a response rate

Logged members
1
Members with repeats
1
Observations
1
Measurements
2
Sources and context

Curated statin-family cases with repeat total cholesterol.

  • report-lines-215-245, reviewed by independent verifier

1 selected case shown with this evidence.

Triglycerides

Laboratory triglyceride result · Aim: lower

Estradiol patch

✓Positive individual result

The Night Shift's triglycerides moved from 230 to 146 mg/dL, about 37% lower, across six months.

Selected member cases

  1. Night Shift · APOE3/4 · female · age 50-59

    Triglycerides fell from 230 to 146 mg/dL across six months; exact elapsed days were not printed.

    What else changed: no nearby starts were recorded.

    Next study: repeat Triglycerides after a dated Estradiol patch window.

1 selected member case · not a response rate

Logged members
34
Members with repeats
1
Observations
1
Measurements
2
Sources and context

Curated estradiol-patch cases with repeat triglycerides; broader estradiol-form users are support context only.

  • report-lines-215-245, reviewed by independent verifier

1 selected case shown with this evidence.

Plain omega-3

✓Positive individual result

The Long Gamer's triglycerides moved from 64 to 40 mg/dL, down 37.5%, across a one-year clean window.

Selected member cases

  1. Long Gamer · APOE4/4 · male · age 60-69

    Triglycerides fell from 64 to 40 mg/dL, down 37.5%, across a one-year clean window.

    What else changed: no nearby starts were recorded.

    Next study: repeat Triglycerides after a dated Plain omega-3 window.

1 selected member case · not a response rate

Logged members
156
Members with repeats
1
Observations
1
Measurements
2
Sources and context

Members with plain omega-3 exposure and repeat triglycerides; the visible case is curated.

  • report-lines-248-343, reviewed by independent verifier

1 selected case shown with this evidence.

Probiotics

✓Positive individual result

One clean curated case lowered triglycerides from 49 to 34 mg/dL in 56 days.

Selected member cases

  1. Triple Mover · APOE3/4 · female · age 40-49

    49 → 34 mg/dL · -30.6% · 56 days

    What else changed: no nearby starts were recorded.

    Next study: repeat Triglycerides after a dated Probiotics window.

1 selected member case · not a response rate

Observations
1
Measurements
2
Sources and context

Members with a logged probiotic and repeat triglyceride result; the visible case is curated.

  • report-lines-248-343, reviewed by independent verifier

1 selected case shown with this evidence.

What may work against

LDL cholesterol

Laboratory LDL cholesterol result · Aim: lower

Estradiol patch

↘Opposite direction

The Night Shift's LDL cholesterol moved opposite the goal, rising 13% while HDL and triglycerides improved.

Selected member cases

  1. Night Shift · APOE3/4 · female · age 50-59

    LDL cholesterol rose 13% across the same six-month estradiol-patch window; paired values were not printed.

    What else changed: no nearby starts were recorded.

    Next study: repeat LDL cholesterol after a dated Estradiol patch window.

1 selected member case · not a response rate

Logged members
34
Members with repeats
1
Observations
1
Measurements
2
Sources and context

Curated estradiol-patch cases with repeat LDL cholesterol; broader estradiol-form users are support context only.

  • report-lines-215-245, reviewed by independent verifier

1 selected case shown with this evidence.

Vitamin D3

↘Opposite direction

One clean curated APOE4/4 case moved opposite the goal, with LDL cholesterol rising 26% across 191 days.

Selected member cases

  1. Vitamin D LDL case · APOE4/4 · female · age not disclosed

    LDL cholesterol rose 26% across a 191-day clean Vitamin D3 window; paired values were not printed.

    What else changed: no nearby starts were recorded.

    Next study: A human repletion trial did not improve lipids and LDL was nonsignificantly higher, making a negative or null Phoenix replication plausible.

1 selected member case · not a response rate

Logged members
159
Members with repeats
1
Observations
1
Measurements
2
Sources and context

Members with a logged Vitamin D3 start and repeat LDL result; the visible case is curated.

  • report-lines-248-343, reviewed by independent verifier

1 selected case shown with this evidence.

Not yet measured

A human repletion trial did not improve lipids and LDL was nonsignificantly higher, making a negative or null Phoenix replication plausible.

How to test it

Baseline
Record LDL cholesterol before the dated Vitamin D3 start.
Duration
84 days
Adherence
Record dose and adherence throughout the window.
Retest
Repeat LDL cholesterol after 12 weeks.
Falsifier
A predeclared Vitamin D3 cohort consistently lowers LDL cholesterol beyond the planned direction-only test.
Eligible-member target
40 members

Still unanswered

Omega-3 Index

Laboratory Omega-3 Index result · Aim: higher

Plain omega-3

?Collecting evidence

The omega-3 family has 156 logged users but only four with both use and a repeat Omega-3 Index; clean eligibility is unknown.

0 selected member cases · not a response rate

Logged members
156
Members with repeats
4
Measurements
8
Sources and context

Members matched to the omega-3 family support question, not only the narrower live-stack catalogue label.

  • report-lines-129-156, reviewed by independent verifier

Collecting evidence

No answer yet on Omega-3 Index

Plain omega-3 is being tracked against Omega-3 Index, but Phoenix has not yet published a ranked result for this exact question.

This question needs 40 carriers with a dated start and a repeat test before Phoenix can answer it. Every carrier who logs one moves this page closer to an answer, including you.

Topic-specific updates about Plain omega-3 · No spam
Not yet measured

The consumed omega-3 family needs matched form, dose and repeat Index measurements rather than assumed status change.

How to test it

Baseline
Record an Omega-3 Index before the dated start.
Duration
112 days
Adherence
Record omega-3 form, dose and adherence throughout the window.
Retest
Repeat the Omega-3 Index after 16 weeks.
Falsifier
A predeclared matched-dose cohort does not raise the Omega-3 Index.
Eligible-member target
40 members

Audit history

These historical records remain beside the current evidence so you can see why their status changed.

LDL cholesterol

Psyllium

!Record under review

LDL cholesterol moved from 263 to 78 mg/dL in 70 days, but an undated ezetimibe entry may be the real actor.

Selected member cases

  1. Fiber Surprise · APOE4/4 · female · age 50-59

    263 → 78 mg/dL · -70.3% · 70 days

    What else changed: nearby starts included ezetimibe start date unknown.

    Next study: Psyllium and ezetimibe both have human LDL evidence, but the Phoenix case cannot assign the observed fall while the ezetimibe start is undated.

1 selected member case · not a response rate

Logged members
1
Members with repeats
1
Observations
1
Measurements
2
Sources and context

Members with a logged psyllium start and repeat LDL result; this case remains disputed because an ezetimibe start is undated.

  • report-lines-248-343, reviewed by independent verifier

1 selected case shown with this evidence.

Not yet measured

Psyllium and ezetimibe both have human LDL evidence, but the Phoenix case cannot assign the observed fall while the ezetimibe start is undated.

How to test it

Baseline
Record LDL cholesterol before every dated intervention start.
Duration
84 days
Adherence
Track psyllium and ezetimibe separately throughout the window.
Retest
Repeat LDL cholesterol after 12 weeks.
Falsifier
The dated combination does not outperform each intervention tracked separately.
Eligible-member target
40 members

This result is under review: The case stays visible but is excluded from active ranks until every start is dated.

Keep the map

Take every result into your next experiment.

Get the Issue 01 Evidence Map by email. It groups the same evidence by outcome and by intervention, including what worked, what did not, and what Phoenix wants to test next.

Instant PDF · Issue 02 lands in your inbox the day it publishes · No spam

Turn evidence into your next test

Magnesium and homocysteine is 7 members from an answer.

Forty carriers with a dated start and a repeat blood test close it. Creatine, vitamin D3 and B12 sit further back. Your next blood test is somebody else's answer, and theirs is yours.

Take the 7-minute assessment