Mild cognitive impairment trials.
557 Mild cognitive impairment trials, curated for APOE4 carriers — 290 of them recruiting. Each one translated into plain English, with our read on what it means for an APOE4 carrier.
- Studies APOE4 response; supplement, MCI onlyNCT00746005Efficacy of Fish Oil Supplementation on Cognition in MCI Patients and the Influence of the APOE4 Allele
This trial tested whether a high daily dose of fish oil, compared with a sunflower oil placebo, changes thinking and memory test results and blood flow in the…
- Open to carriers, not 4-specificNCT01482351Mild Cognitive Impairment and Obstructive Sleep Apnea
This study looked at whether sticking with CPAP, the mask-and-airflow machine for sleep apnea, is linked to memory, thinking, and daily function after one year…
- Observational only, China-based populationNCT03653156China Cognition and Aging Study
This is a large observational study based in China, not a drug or treatment trial. Researchers are building a national database by following thousands of…
- Exclusively enrolls APOE4 homozygotesNCT03887741Plasmapheresis Versus Plasma Infusion from Young APOE3 Homozygotes Into MCI APOE4 Homozygotes to Slow Disease Progression
This trial is testing whether it is safe to give plasma from young APOE3 carriers to people who are APOE4 homozygous and already showing mild cognitive…
- Studies APOE4 effect; device, not drugNCT04012346Modulation of Cognition and Brain Connectivity by Noninvasive Brain Stimulation in Patients With Mild Cognitive Impairment Due to Alzheimer's Disease
This study uses repetitive transcranial magnetic stimulation, a noninvasive device that sends magnetic pulses through the scalp, to see whether it changes…
- Directly recruits APOE4 carriersNCT04430517Effects of Nicotinamide Riboside on Bioenergetics and Oxidative Stress in Mild Cognitive Impairment/Alzheimer's Dementia
This early-phase trial is testing nicotinamide riboside, a form of vitamin B3, in people who already have mild cognitive impairment or mild Alzheimer's…
- Requires at least one APOE4 alleleNCT05245903Passive Sensor Identification of Digital Biomarkers to Assess Effects of Orally Administered Nicotinamide Riboside
This trial is testing whether a supplement called nicotinamide riboside (a form of vitamin B3) produces measurable changes in brain energy metabolism in people…
- Mentions APOE4, enrollment unconfirmed; MCI onlyNCT05321498Study to Assess the Efficacy of XPro1595 in Patients With Mild Cognitive Impairment With Biomarkers of Inflammation
This trial tests a drug called XPro1595 against a placebo in people with mild cognitive impairment (MCI) who show signs of brain inflammation. Researchers will…
- Drug trial — APOE4 carriers excludedNCT05986721Clinical Trial of AGB101 for Mild Cognitive Impairment
This trial tests AGB101, a once-daily pill (220 mg), against a placebo for 78 weeks in people with mild cognitive impairment likely due to Alzheimer's.…
- APOE4 carriers central to studyNCT06335836The Effects of Social Isolation and Social Interaction on the Risk of Dementia Progression and Brain Function in SCD (Subjective Cognitive Decline, SCD)
This trial is studying how social isolation and social interaction affect the brain and the risk of progressing from subjective cognitive decline to more…
- APOE4 genotyped, non-drug device trialNCT06467253Comparison of Two Non-invasive Neuromodulation Techniques as Synergistic Therapy to Cognitive Stimulation in Amnestic Mild Cognitive Impairment (aMCI)
This trial is testing two types of non-invasive brain stimulation — repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current…
- Genotype-stratified, carriers likely eligibleNCT07027072Study to Evaluate the Efficacy and Safety of KDS2010 in Patients With Alzheimer's Disease With Mild Cognitive Impairment and Mild Dementia Due to Alzheimer's Disease
This trial is testing KDS2010, an experimental oral drug taken once daily, in people who have early Alzheimer's-related memory problems — either mild cognitive…
- APOE4 4/4 carriers excludedNCT07456462Making Antibody Treatments More Effective in Early Alzheimer's Disease Using 3Tesla Magnetica Resonance
This study is testing whether advanced MRI scans and blood tests can predict how well lecanemab or donanemab are working in people with early Alzheimer's…
- Exclusively recruits APOE4 carriersNCT07516119Predicting Pre-dementia
This observational study is testing whether a multimodal prediction model — combining genetic risk scores, blood biomarkers, health record data, and wearable…
- APOE4 carriers explicitly excludedNCT07612449Percepta for Cognitive Optimization
This trial is testing a dietary supplement called Percepta, made from cat's claw bark extract and oolong tea extract, to see whether it improves cognitive…
- Exclusively recruits APOE4 carriersNCT07646054Digital Lifestyle Coaching for Alzheimer's Disease Prevention in APOE4 Carriers
This trial is testing whether a year-long digital lifestyle coaching program can improve blood-based markers linked to Alzheimer's risk. Twelve hundred…
- APOE4 subgroup specifically analyzedNCT07766993Developing and Testing an AI-Based Cognitive Intervention Program
This trial is testing whether an AI-guided lifestyle program — covering diet, exercise, mental activity, sleep, social connection, and stress — can help…
- Observational surgery study, APOE4 measuredNCT07885085Postsurgical Pain and Opioid Use in Older Adults: Effects of Mild Cognitive Impairment
This is an observational study, so nothing is being tested as a treatment. Researchers will follow older adults with and without mild cognitive impairment…
- Observational study, not APOE4-specificISRCTN52227045Life-style and multi-omics to approach cognitive decline and dementia
This is an observational study, not a drug test. Researchers in Spain will follow over 300 people aged 45 to 80 with subjective cognitive decline or mild…
- Supplement study, APOE4 not addressedISRCTN52580708The effectiveness of a supplement containing standardized Cosmos caudatus extract on memory, mood and cognitive-related biomarkers in the ageing population with mild cognitive impairment
This trial is testing whether a daily capsule made from Cosmos caudatus, a Malaysian leafy plant, improves memory, mood, and blood markers linked to thinking…
- Device study, genotype not specifiedISRCTN55017737Understanding mild cognitive impairment through multimodal biomarkers and brain stimulation
This study looks at brain stimulation, using a device that sends a weak electrical current through the scalp, in older adults with mild cognitive impairment…
- Device study, not APOE4-specificISRCTN66816361Acceptance and validation of virtual reality technologies for enhancing wellbeing and the early detection of cognitive decline in older adults
This European study looks at whether older adults with memory complaints or mild cognitive impairment find virtual reality tools acceptable and easy to use.…
- Lifestyle pilot, not APOE4-specific, MCI onlyISRCTN77616491Developing a brain health programme for people with Mild Cognitive Impairment to reduce dementia risk
This small UK study is testing whether a group brain health programme can work in an NHS clinic. It mixes health education, group talks and memory training for…
- Assessment tool study, not APOE4-specificISRCTN87242816Adaptation and validation of the Erlangen activities of daily living test to the Latin American cultural area
This study is testing a Spanish-language, Mexico-adapted version of a hands-on test that measures everyday skills, like the tasks of daily living, in people…
- Open to carriers, not 4-specificNCT01532739Making Memory Better for Seniors With Mild Cognitive Impairment
This trial tests a group-based cognitive training program for people with Mild Cognitive Impairment (MCI). It focuses on everyday memory problems and pairs…
- Observational study, not APOE4-specificNCT01555411Akershus Cardiac Examination (ACE) 1950 Study
This is an observational study, meaning no drug or treatment is being tested. Researchers in Akershus County, Norway, are following a large group of people…
- Device study, MCI only, not 4-specificNCT01888029Influence of tDCS on Cortical Plasticity in Patients With Mild Cognitive Impairment (MCI)
This study tests whether a gentle electrical current applied to the scalp, called tDCS, changes how adaptable the brain's movement area is in people with mild…
- Non-drug study, genotype not requiredNCT02386670Prevention of Alzheimer's Disease With CR Plus tDCS in Mild Cognitive Impairment and Depression (PACt-MD)
This trial tests whether gentle electrical brain stimulation through the scalp (tDCS), paired with computer-based brain training (cognitive remediation), slows…
- Imaging study, genotype not mentionedNCT02420470The Early Warning System for the Diabetic Encephalopathy
This study uses advanced brain MRI scans to look for early changes in the brains of people with type 2 diabetes or prediabetes. Researchers want to see whether…
- Open to carriers, genotype not consideredNCT02525198The Cognitive Ageing Nutrition and Neurogenesis (CANN) Trial
This trial is testing a dietary supplement that combines fatty acids (like omega-3s) and flavonoids (plant-based compounds) to see whether the combination…
- Open to carriers, not 4-specificNCT02814526Exercise in Adults With Mild Memory Problems
This trial tests whether aerobic exercise (like treadmill walking) does more for brain health than stretching and balance routines in older adults with mild…
- Exercise study, not APOE4-specificNCT02913053The Effects of an Extensive Exercise Program on the Progression of Mild Cognitive Impairment
This study compares three groups of people with mild cognitive impairment: a 12-month aerobic exercise program, a stretching and toning program, and a group…
- Observational only, no treatment involvedNCT02951598A Study of Health Care Use and Costs in Participants With Early Stage Alzheimer's Disease (AD)
This study is not testing a treatment. It is an observational study tracking how people with early-stage Alzheimer's disease or MCI use health care, what that…
- Imaging study, genotype not specifiedNCT02958670Imaging Tau Deposition in the Brain of Elderly Subjects
This study uses a brain scan with a tracer called 18F-AV-1451 to see where tau protein builds up in older adults. Tau and amyloid are two proteins linked to…
- Non-drug trial, genotype not consideredNCT02959502Home-Based CR and tDCS to Enhance Cognition in Persons With Mild Cognitive Impairment and Late Life Depression
This trial is testing a home-based combination of cognitive rehabilitation (structured mental exercises) and transcranial direct current stimulation (tDCS, a…
- Observational gait study, not APOE4-specificNCT03020381Gait as Predictor of Dementia and Falls. The Gait and Brain Cohort Study
This is an observational study, not a drug test. Researchers watch how older adults walk while doing a simple thinking task, such as talking or counting. They…
- Parkinson's trial, genotype not relevantNCT03025334tDCS on Parkinson's Disease Cognition
This trial is testing whether a non-invasive brain stimulation technique called high-definition transcranial direct current stimulation (HD-tDCS) can improve…
- Open to carriers, genotype not trackedNCT03113461MCI: CPAP Treatment of OSA (Memories2)
This trial is testing whether CPAP — the device used to treat sleep apnea — can slow the progression of memory problems in people who already have mild…
- Observational only, genotype not requiredNCT03136679Discovery of Novel Biomarkers That Will Lead to the Early Detection of Alzheimer's Disease
This study is collecting blood and urine samples from people with varying degrees of cognitive impairment to search for new biological markers that might…
- Observational study, not APOE4-specificNCT03140865Wake Forest Alzheimer's Disease Clinical Core
This is an observational study, not a drug test. Researchers at Wake Forest follow people with normal thinking, mild cognitive impairment, or mild Alzheimer's.…
- Surgery study, genotype not specifiedNCT03147937Cognitive Changes After Major Joint Replacement - Full Trial (Cognigram 2)
This study tracks changes in thinking and memory in people age 50 and older having a hip or knee replacement. Researchers use a computer-based cognitive test…
- Observational only, genotype not relevantNCT03162081Medication Misuse and Dependence Among Elderly
This study is looking at how older adults use — and sometimes misuse — prescription medications, particularly drugs that can be habit-forming. Researchers are…
- Observational study, not APOE4-specificNCT03174938The Swedish BioFINDER 2 Study
BioFINDER 2 is an observational study in Sweden. It uses brain scans (amyloid and tau PET), spinal fluid tests, and MRI to track how Alzheimer's and related…
- Explicitly lists APOE4-positive carriersNCT03233646Retinal Imaging in Neurodegenerative Disease
This study uses non-invasive eye-imaging technology — optical coherence tomography (OCT) and wide-field retinal photography — to look for early signs of…
- Open to carriers, not 4-specificNCT03263247Cognitive Training in Patients With MCI Using fMRI
This trial is testing whether two types of cognitive training — a visual memory technique and an alphabet-search exercise — improve brain function in people…
- Imaging study, not APOE4-specificNCT03372317Tau PET in Imaging and Cognition: Healthy Adults From 55-90
This study uses a brain scan tracer called 18F-MK-6240 to look for tau, a protein that builds up in Alzheimer's, in healthy older adults and people with mild…
- Observational study, genotype not specifiedNCT03402919Comprehensive Assessment of Neurodegeneration and Dementia
This is an observational study, meaning no drug or treatment is being tested. Researchers across Canada will follow people aged 50 to 90 over time, including…
- Behavioral study, genotype not consideredNCT03430401Computer-based Cognitive Rehabilitation Program for Healthy Older Adults, Older People With Mild Cognitive Impairment and Mild Dementia
This trial tests a computer-based memory training program delivered via iPad. Participants learn specific strategies for encoding — or storing — memories more…
- Non-drug study, genotype not requiredNCT03444181ALzheimer and MUsic THerapy: Effects of Music Lessons on Brain Plasticity, Mood, and Quality of Life in Alzheimer Patients
This trial is testing whether a year of music lessons designed for people with Alzheimer's disease can slow brain shrinkage, improve mood, and raise quality of…
- Open to carriers, not 4-specificNCT03493178Glutathione in Mild Cognitive Impairment
This trial is testing whether two dietary supplements, glycine and N-acetylcysteine (NAC), can raise glutathione levels in people with mild cognitive…
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Educational, not medical advice. Trial decisions belong between you and your physician.