NCT00746005 · COMPLETED
Efficacy of Fish Oil Supplementation on Cognition in MCI Patients and the Influence of the APOE4 Allele
This trial tested whether a high daily dose of fish oil, compared with a sunflower oil placebo, changes thinking and memory test results and blood flow in the brain over a short period. Participants had mild cognitive impairment. It is a supplement study with no phase label, so it is not a drug approval trial and proves nothing on its own.
You may qualify if
- Men and women
- Diagnosed as having amnestic MCI: based on specific memory disturbances (cut-off of 1 sd, single or multiple domain amnestic MCI, according to Busse A et al37)
- Presence of a principal caregiver willing to assist for a successful participation
- Informed consent signed
You're excluded if
- Current or recent (\<4 weeks) use of fish oil supplements
- Consumption of fish more than 2 times/week
- Current use of dementia (Alzheimer) medication
- Current use of acenocoumarol or other anti-thrombotic drugs (because of the high dose of fish oil)
- Serious liver disease
- Use of more than 4 glasses of alcohol per day
- Unable to participate as judged by the responsible medical physician
- Allergy to fish(oil)
- Swallowing problems
- Participation in another clinical trial less than 2 months before the start of the trial or at the same time
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2011-01-12