NCT03402919 · RECRUITING
Comprehensive Assessment of Neurodegeneration and Dementia
This is an observational study, meaning no drug or treatment is being tested. Researchers across Canada will follow people aged 50 to 90 over time, including people with memory problems, Parkinson's, and healthy comparison volunteers. Participants get cognitive testing, brain imaging, and biological samples collected. The goal is to better understand how these conditions develop and change.
You may qualify if
- Has subjective or objective cognitive impairment
- Written informed consent must be obtained and documented (from the patient or, where jurisdictions allow it, from a caregiver/family member)
- Sufficient proficiency in English or French to undertake self report and neuropsychological testing
- Geographic accessibility to the study site
- Must have a study partner who can participate as required in the protocol (provide corroborative information)
- Up to 12 years of education
- Fits into one of the following groups: Cognitively Unimpaired, Subjective Cognitive Impairment, Mild Cognitive Impairment, Vascular Mild Cognitive Impairment, Parkinson's Disease, Parkinson's Disease with Mild Cognitive Impairment
You're excluded if
- The presence of other significant known chronic brain disease such as: moderate to severe chronic static leukoencephalopathy (including previous traumatic injury), multiple sclerosis, a serious developmental handicap, malignant tumors, Parkinson's disease (other than for the Parkinson's cohort), and other rarer brain illnesses
- Ongoing alcohol or drug abuse which in the opinion of the investigator may interfere with the subject's ability to comply with the study procedures
- Symptomatic stroke within the previous year
- Unable to undergo MRI scan due to medical contraindications or inability to tolerate the procedure
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-01-20