Subjective cognitive decline trials.
60 Subjective cognitive decline trials, curated for APOE4 carriers — 42 of them recruiting. Each one translated into plain English, with our read on what it means for an APOE4 carrier.
- APOE4 carriers central to studyNCT06335836The Effects of Social Isolation and Social Interaction on the Risk of Dementia Progression and Brain Function in SCD (Subjective Cognitive Decline, SCD)
This trial is studying how social isolation and social interaction affect the brain and the risk of progressing from subjective cognitive decline to more…
- APOE4-focused, but prior participants onlyNCT07730671PENSA+: Extended Follow-up of a Multimodal Lifestyle Intervention to Prevent Cognitive Decline in APOE-ε4 Carriers
PENSA+ is a follow-up study checking whether the effects of an earlier lifestyle program last about five years later. The original program combined several…
- Observational study, not APOE4-specificISRCTN52227045Life-style and multi-omics to approach cognitive decline and dementia
This is an observational study, not a drug test. Researchers in Spain will follow over 300 people aged 45 to 80 with subjective cognitive decline or mild…
- Lifestyle pilot, not APOE4-specific, MCI onlyISRCTN77616491Developing a brain health programme for people with Mild Cognitive Impairment to reduce dementia risk
This small UK study is testing whether a group brain health programme can work in an NHS clinic. It mixes health education, group talks and memory training for…
- Observational gait study, not APOE4-specificNCT03020381Gait as Predictor of Dementia and Falls. The Gait and Brain Cohort Study
This is an observational study, not a drug test. Researchers watch how older adults walk while doing a simple thinking task, such as talking or counting. They…
- Observational study, genotype not specifiedNCT03402919Comprehensive Assessment of Neurodegeneration and Dementia
This is an observational study, meaning no drug or treatment is being tested. Researchers across Canada will follow people aged 50 to 90 over time, including…
- Lifestyle study, genotype not requiredNCT03772977The Brain Health Champion Study
This trial tests whether more frequent, personalized coaching on brain-healthy habits produces better follow-through than standard doctor advice alone.…
- Observational only, genotype not specifiedNCT03851523Longitudinal Study for the Characterization of the Phases of Subjective Perception of Cognitive Decline and Mild Cognitive Impairment of Alzheimer's Disease.
This observational study tracks people over time to understand the very earliest signs of Alzheimer's disease — specifically, what happens when someone feels…
- Open to carriers, genotype not requiredNCT05014893Neural Mechanisms of Cognitive Assessment and Rehabilitation for Cognitive Decline
This study looks at how and why cognitive function declines, and tests whether a combination of cognitive training, exercise, and games can improve or restore…
- Open to carriers, not 4-specificNCT05331144Impact of Intensive Treatment of SBP on Brain Perfusion, Amyloid, and Tau (IPAT Study)
This Phase 2 trial is testing whether aggressively lowering systolic blood pressure — using two common prescription medications, losartan and amlodipine —…
- Lifestyle study, genotype not consideredNCT05534607Natives Engaged in Alzheimers Research - 'Ike Kupuna
This trial is testing whether a traditional hula dancing program called Ola Mau i ka Hula can improve vascular risk factors — things like blood pressure, blood…
- Open to carriers, not 4-specificNCT05881239Digital Accessible Remote Olfactory Mediated Health Assessments for Preclinical AD
This study is testing a smell-based assessment tool called the AROMHA Brain Health Test to see whether changes in the sense of smell can help identify early…
- Observational study, genotype not consideredNCT05893524Uppsala-Dalarna Dementia and Gait Project
This project is testing whether a simple walking-and-talking test called the TUG dual-task can help detect early signs of cognitive decline and predict future…
- Behavioral study, genotype not consideredNCT06005038CogT pSOPT Intervention Study
This trial is testing a personalized computer-based brain training program called pSOPT for people with mild or subjective cognitive impairment. The program…
- Open to carriers, not 4-specificNCT06058611Effects of a Computerised Cognitive Stimulation Versus Stimulating Leisure Activities
This trial compares two non-drug approaches for older adults with mild or subjective cognitive impairment: a personalized computerized cognitive stimulation…
- Observational only, genotype not consideredNCT06089096Sleep Apnea and Cognitive Function in Subjects With Subjective or Mild Cognitive Impairment
This study is testing whether people with early memory concerns — either mild cognitive impairment or subjective cognitive complaints — also have undiagnosed…
- Family history required, genotype not trackedNCT06095063dTMS for Subjective Cognitive Decline
This trial is testing whether deep transcranial magnetic stimulation (dTMS) — a non-invasive device that uses magnetic pulses to stimulate specific brain…
- Sleep-focused study, genotype not requiredNCT06150352Sleep Apnea, Neurocognitive Decline and Brain Imaging in Patients With Subjective or Mild Cognitive Impairment
This trial is studying whether treating obstructive sleep apnea with CPAP or similar devices helps slow cognitive decline in people who already notice memory…
- Open to carriers, not 4-specificNCT06340659Concurrent Aerobic Exercise and Cognitive Training to Prevent Alzheimer's in At-risk Older Adults (The Exergames Telerehabilitation Study)
This trial compares two home-based, telehealth exercise programs for older adults who notice they are forgetting things more than before. One group does…
- Open to carriers, not 4-specificNCT06403345A Feasiblity Study of Green Activity Program for People Living With Memory Challenges
This study tests a structured program of outdoor nature activities — things like dog walking, gardening, hiking, and outdoor yoga — for people already…
- Observational study, genotype not mentionedNCT06539403Thinking About Memory: How Confident Are You in Your Memory, and Does it Change With Age?
This study looks at how people with and without memory concerns think about their own memory abilities — a concept called metacognition. Participants complete…
- Open to carriers, not 4-specificNCT06542458Under-Represented Communities Diagnosed With SCD or MCI Through Tele-Cog
This observational study is following older adults from underrepresented and under-resourced communities who have already been diagnosed with subjective…
- Open to carriers, not 4-specificNCT06561906Establish Diagnostic and Prognostic Models for Preclinical AD Patients Based on Multimodal MRI, Behavioral, Genetic, and Plasma Biomarkers
This study is not testing a drug or treatment. Researchers are combining brain MRI scans, memory and behavior tests, genetic information, and blood markers to…
- Open to carriers, not 4-specificNCT06588946Β-OHB Supplementation and Brain Health in Older Adults
This trial tests whether a ketone supplement, taken for 14 days, changes blood flow and brain network activity in older adults who notice memory slips but test…
- Observational only, genotype not addressedNCT06621758Communication Regarding Preclinical Dementia Diagnostic and Diagnostic Disclosure Among Patients with MCI and SCD
This study uses questionnaires to learn what people with mild cognitive impairment or subjective cognitive decline want to know during diagnostic counseling —…
- Observational only, genotype not addressedNCT06650969China Diabetes Cognitive Dysfunction Early Diagnosis and Intervention Study (China-DECODE Study)
This is an observational study based in China tracking people with Type 2 diabetes to better understand how and why cognitive problems develop over time, from…
- Non-drug study, genotype not consideredNCT06657274EARLY-COGN^3 - Smart Digital Solutions for EARLY Treatment of COGnitive Disability: a Neuropsychological, Neurophysiological and Neurobiological Perspective in Chronic Neurological Diseases - PNRR-MCNT2-2023-12377069
This trial is testing a home-based digital cognitive training program called RICORDO-DTx against unstructured at-home mental stimulation, in people with mild…
- Sleep device study, genotype not specifiedNCT06669546Effects of Real vs. Soundless Acoustic Stimulation During Deep Sleep on Brain Activity, Memory, and Blood Biomarkers in Older Adults (60-85) With Mild Memory Impairment
This study tests whether gentle sounds timed to brain rhythms during deep sleep can improve sleep, memory, and blood markers linked to dementia. Sixty older…
- Observational only, genotype irrelevantNCT06701630Italian Adaptation and Validation of Functional and Behavioural Scales for Subjective Cognitive Decline, Mild Cognitive Impairment and Mild Dementia.
This study is not a treatment trial. Researchers in Italy are translating and validating a set of questionnaires used to measure daily functioning and behavior…
- Diagnostic tool study, genotype irrelevantNCT06711952German Validation Study of the Subjective Cognitive Decline Questionnaire (SCD-Q)
This study is testing whether a self-reported questionnaire called the SCD-Q accurately measures how people perceive their own memory and thinking changes — in…
- Non-drug trial, genotype not specifiedNCT06821828The Efficacy of Modified Olfactory Training for MCI High-Risk Individuals
This trial is testing whether a modified smell-training device can slow cognitive decline in older adults who already show early warning signs: mild olfactory…
- Observational registry, genotype not addressedNCT06889818Korean Joint Registry for Alzheimer's Treatment and Diagnostics (JOY-ALZ)
This is a real-world registry study based in Korea, not a randomized drug trial. It is tracking how well anti-amyloid antibody therapies like lecanemab and…
- Lifestyle study, not APOE4-specificNCT06896201Comfortage - AD Prevention Strategies
This Italian study looks at lifestyle-based approaches to Alzheimer's prevention in people with subjective cognitive decline or mild cognitive impairment. It…
- Open to carriers, not 4-specificNCT06993207HOme-based Brain Monitoring With a GARment-EEG to Study Cognitive Decline in the Aging Population
This study is testing a wearable EEG headband kit called HOGAR, designed to monitor brain activity and sleep at home. Researchers want to know whether this…
- Open to carriers, not 4-specificNCT07051239Sleep Stimulation to Enhance Waste Clearance in the Brain
This study tests whether gentle sounds played during sleep, timed to your brain's slow waves, can boost the brain's waste-clearing activity and help memory.…
- Open to carriers, genotype not consideredNCT07051408Predictors Of Cognitive Decline Using Digital Devices
This study is testing whether people with memory concerns will actually use digital devices — a smartwatch, a sleep headband, and smartphone apps — in their…
- Open to carriers, genotype not requiredNCT07130669FACE Phase II (a Stage II Trial)
This trial is testing a facial expression-based software engine that watches your face during at-home brain-training exercises and adjusts the difficulty in…
- Non-drug device trial, genotype not requiredNCT07212504Effect of Accelerated Neuromodulation of Anterior Cingulate Cortex to Enhance Cognition in Older Adults With Mild Memory Problems
This trial is testing whether a non-invasive brain stimulation technique called deep Transcranial Magnetic Stimulation (dTMS), delivered in an accelerated…
- Observational registry, not APOE4-specificNCT07213700InRAD Observational Study
This is an observational registry, not a treatment trial. Nothing is given to participants. Researchers collect real-world health information from people being…
- Open to carriers, not 4-specificNCT07236190Biomarker-based Trial of NPC-1 for Alzheimer's Pathology
This trial is giving one group of older adults a combination of two plant-derived compounds, parthenolide and ipriflavone, and checking blood markers of…
- Non-drug study, genotype not mentionedNCT07286448Personalized Digital Training for COGnitive FITness in Mild Cognitive Impairment
This trial tests a home-based digital brain-training app called RICORDO against a paper-and-video education program called S.A.M.B.A. in people aged 50 and…
- Behavioral study, genotype not specifiedNCT07289061Positive Psychology for Early Cognitive Decline: Effects on Cognitive and Brain Function
This study tests whether a 24-week Positive Psychology program, done in small online groups with short home practices, improves thinking and brain function in…
- Open to carriers, not 4-specificNCT07364019The Brain Health PRO Online Risk Factor Reduction Study to Prevent Dementia
This trial is testing an online educational program called Brain Health PRO, which teaches lifestyle changes aimed at reducing dementia risk. Over six months,…
- Lifestyle study, genotype not requiredNCT07376135LETHE-AT: a Personalized Multidomain Lifestyle Intervention for Individuals at Increased Risk of Memory Impairment.
This trial is testing whether a personalized, technology-assisted lifestyle program — covering exercise, diet, sleep, cognitive training, and social activity —…
- Supplement study, not APOE4-specificNCT07383311Autophagy-Enhancers to Reduce Sleep Disturbances
This trial tests whether spermidine, a natural compound found in foods like wheat germ and soybeans, taken as a daily supplement for 12 weeks, changes sleep…
- APOE4 genotype explicitly analyzedNCT07402161The Signature of Alzheimer's Disease in Subjective Cognitive Decline
This study is testing whether a combination of tools — blood biomarkers, EEG brain recordings, speech analysis, and genetic profiling — can reliably spot early…
- Non-drug sleep study, not APOE4-specificNCT07440498Study of Bedroom Environment Sleep Intervention at Home for Older Adults Living Alone With Memory Concerns
This small pilot study tests whether simple bedroom changes plus brief sleep habit coaching can improve sleep in adults 65 and older who live alone, have…
- Exercise study, genotype not specifiedNCT07444554High-Velocity Resistance Training for Brain Blood Flow and Cognitive Function in Older Adults
This trial tests whether 12 weeks of supervised, fast-movement strength training changes how well blood flows in the brain, and whether thinking skills like…
- Observational only, Italy-based, not 4-specificNCT07457138Lombard Cohort of Brain Health Services
This Italian observational study is enrolling about 1,000 adults in the Lombardy region who have subjective memory concerns but no diagnosed cognitive…
- APOE4 response explicitly studiedNCT07479914Art of Memory for Cognitive Enhancement in the Monza Brain Health Service
This pilot trial is testing whether structured memory technique training (mnemonics, or the art of memory) improves cognitive performance in adults over 50…
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Educational, not medical advice. Trial decisions belong between you and your physician.