NCT06588946 · Phase 2 · NOT YET RECRUITING
Β-OHB Supplementation and Brain Health in Older Adults
This trial tests whether a ketone supplement, taken for 14 days, changes blood flow and brain network activity in older adults who notice memory slips but test normally. Everyone also takes a placebo for 14 days, in random order. It is a Phase 2 trial, testing early effects and safety, not yet proven or approved.
You may qualify if
- Being objectively cognitively normal as determined by a Montreal Cognitive Assessment (MoCA) score ≥26 with independent living and ambulating
- SCD will be determined using the Prospective-Retrospective Memory Questionnaire (PRMQ) following the SCD Initiative Working Group framework
You're excluded if
- A diagnosis of mild cognitive impairment, dementia, or psychiatric and/or mood disorders (e.g., major depression)
- MoCA score \<26
- Diagnosis of cardiometabolic disease (e.g., hypertension, type 2 diabetes)
- Obesity (BMI >30 kg/m2)
- History of heart attack or stroke
- History of smoking
- Currently following a ketogenic diet or taking ketogenic supplements
- Having MRI contraindications
- Participants with literacy, visual, hearing, and/or speech issues, as well as individuals who are not proficient in English will not be eligible for this trial
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-02-26