NCT07730671 · NOT YET RECRUITING
PENSA+: Extended Follow-up of a Multimodal Lifestyle Intervention to Prevent Cognitive Decline in APOE-ε4 Carriers
PENSA+ is a follow-up study checking whether the effects of an earlier lifestyle program last about five years later. The original program combined several lifestyle changes, with or without a green tea compound called EGCG. Researchers will measure memory and thinking, brain scans, and blood markers. No new intervention is given, and no phase is listed.
Eligibility criteria
Inclusion Criteria - Any individual who has completed the PENSA study, does not meet any exclusion criteria, and provides consent is eligible to participate in this study. Exclusion Criteria Participants will be excluded from the study if they meet any of the following conditions: * A prior clinical diagnosis of dementia, regardless of etiology. * Current institutionalization (e.g., residence in nursing homes, long-term care facilities, or similar institutions). * Impaired decision-making capacity, defined as the inability to provide informed consent independently due to cognitive, legal, or medical reasons (e.g., loss of autonomy or requirement of a legal representative). * Current participation in another interventional clinical trial, or participation in an interventional clinical trial within the previous 3 months prior to baseline; unless deemed by the investigator not to interfere with PENSA+ procedures or outcomes.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-07-28