Sleep Stimulation to Enhance Waste Clearance in the Brain

Eligibility criteria

For the positive amyloid load group:
-Participants who meet the criteria of subjective cognitive decline or mild cognitive impairment (Clinical Dementia Rating \< 2; Mini-Mental State Examination ≥ 21) and brain amyloid-beta (Aβ) accumulation confirmed by CSF or amyloid-PET, the inclusion age range is 55-80 years.
For healthy groups:
-Inclusion age range is 18-80 years.
Inclusion criteria:
* Proficiency in the French language (close to native level) to complete the neuropsychological evaluation and cognitive tests.
* MRI compatibility: absence of metallic materials in the body (implants, vascular clips, certain types of orthopedic material, etc.), a pacemaker or other types of stimulators, cochlear implants, or any other electronic devices.
Exclusion criteria:
* Current or past psychiatric or neurological conditions (except for those directly associated with the patient group).
* The presence of severe untreated sleep disorders.
* The presence of irregular sleep-wake cycles (due to shiftwork or extreme chronotype).
* The presence of moderate depression or high levels of anxiety.
* Ongoing treatment with psychotropic medications (benzodiazepines, antidepressants).
* Regular or excessive consumption of alcohol or caffeinated drinks.
* Consumption of other psychoactive substances known to have an impact on the central nervous system.
* Insufficient visual or auditory acuity to complete the assessments if uncorrected. Normal hearing is required for sound stimulation to be effective.
* Claustrophobia that prevents undergoing brain imaging (MRI).
* Pregnancy or currently breastfeeding

The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.

Eligibility criteria as of 2025-07-09