NCT07444554 · NOT YET RECRUITING
High-Velocity Resistance Training for Brain Blood Flow and Cognitive Function in Older Adults
This trial tests whether 12 weeks of supervised, fast-movement strength training changes how well blood flows in the brain, and whether thinking skills like processing speed and executive function improve. Half the group trains three times a week; half keeps usual routines. It is not a drug study. The phase label is not applicable, since this is an exercise study.
You may qualify if
- Age 60 to 79 years
- Able to walk on a treadmill at a comfortable, self-selected pace for at least 30 minutes with short breaks
- Has at least one vascular risk factor (such as high blood pressure or high cholesterol)
- Has a first-degree family history of dementia or self-reported concerns about memory or thinking
- Fluent in English
- Willing and able to provide written informed consent
- Cleared to participate in supervised resistance training based on physical activity screening and, if required, physician clearance
You're excluded if
- Diagnosis of Alzheimer disease, other dementia, stroke, Parkinson disease, multiple sclerosis, or another major neurological disorder
- Unstable cardiovascular disease (such as recent heart attack, unstable chest pain, or uncontrolled abnormal heart rhythm)
- Uncontrolled high blood pressure
- Major psychiatric illness that would interfere with participation
- Medical condition that makes moderate-to-high intensity resistance training unsafe
- Current participation in structured high-intensity resistance training
- Any medical condition that, in the opinion of the study investigator, would increase risk during participation
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-10-14