ISRCTN52227045 · RECRUITING
Life-style and multi-omics to approach cognitive decline and dementia
This is an observational study, not a drug test. Researchers in Spain will follow over 300 people aged 45 to 80 with subjective cognitive decline or mild cognitive impairment for about 10 years. Visits happen every 2 years. They will track diet, lifestyle, metabolism and gut bacteria alongside memory changes. No phase is listed.
You may qualify if
- Men and women aged between 45-80 years old
- Mini-Mental State Examination (MMSE) ≥ 26, hospital anxiety scale ≤ , hospital depression scale ≤ 11
You're excluded if
- Mini-Mental State Examination (MMSE) <26 or inability to give informed consent
- Diagnosis of dementia
- Presence of depressive symptoms (Geriatric Depression Scale ≤5)
- Major medical or psychiatric condition
- Evidence of impairment due to psychoactive drugs
- Alcohol or drug abuse
- Inability to perform imaging studies (i.e.CAT, MR)
- Other conditions under the neurologist criteria
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2023-05-30
Source: ISRCTN registry, record ISRCTN52227045, retrieved 2026-10-27. Registry text licensed CC BY 4.0.