Recruiting now.
1133 APOE4-relevant Alzheimer’s trials are recruiting participants right now. Each one translated into plain English, with our read on what it means for an APOE4 carrier.
- Observational only, China-based populationNCT03653156China Cognition and Aging Study
This is a large observational study based in China, not a drug or treatment trial. Researchers are building a national database by following thousands of…
- Excludes APOE4 homozygotes (4/4 carriers)NCT03671889ExAblate Blood-Brain Barrier (BBB) Disruption for the Treatment of Alzheimer's Disease
This study tests whether a focused-ultrasound device, guided by MRI, can safely and temporarily open the blood-brain barrier in people with probable…
- APOE4 carriers explicitly includedNCT04575337Study on Biomarkers for Early Diagnosis of Alzheimer's Disease
This is an observational study based in China that is tracking elderly people over five years to identify early biological markers of Alzheimer's disease.…
- Requires at least one APOE4 alleleNCT05245903Passive Sensor Identification of Digital Biomarkers to Assess Effects of Orally Administered Nicotinamide Riboside
This trial is testing whether a supplement called nicotinamide riboside (a form of vitamin B3) produces measurable changes in brain energy metabolism in people…
- APOE4 carriers explicitly namedNCT05649514Sleep Impairment in Subjects at Risk of Developing Alzheimer's Disease
This study is observing whether poor sleep is linked to cognitive decline in people at early risk of Alzheimer's. Participants undergo sleep studies, cognitive…
- APOE4 carriers central to studyNCT06335836The Effects of Social Isolation and Social Interaction on the Risk of Dementia Progression and Brain Function in SCD (Subjective Cognitive Decline, SCD)
This trial is studying how social isolation and social interaction affect the brain and the risk of progressing from subjective cognitive decline to more…
- APOE4 genotyped, non-drug device trialNCT06467253Comparison of Two Non-invasive Neuromodulation Techniques as Synergistic Therapy to Cognitive Stimulation in Amnestic Mild Cognitive Impairment (aMCI)
This trial is testing two types of non-invasive brain stimulation — repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current…
- Observational only, genotype not studiedNCT06818409Is the CRP-Albumin-Lymphocyte (CALLY) Index Effective in Predicting Postoperative Delirium in Geriatric Patients Undergoing Hip Fracture Surgery
This study is testing whether a simple blood-test index called the CALLY Index, which combines three routine lab values, CRP, albumin, and lymphocyte count,…
- Actively recruits APOE4 carriersNCT07007208Biomarkers of the Locus Coeruleus Nucleus: Links With Early Tau Pathology, Cognition and Alzheimer's Disease Risk
This trial is studying a brain region called the locus coeruleus, which may show early signs of tau protein buildup before other areas affected in Alzheimer's.…
- Genotype-stratified, carriers likely eligibleNCT07027072Study to Evaluate the Efficacy and Safety of KDS2010 in Patients With Alzheimer's Disease With Mild Cognitive Impairment and Mild Dementia Due to Alzheimer's Disease
This trial is testing KDS2010, an experimental oral drug taken once daily, in people who have early Alzheimer's-related memory problems — either mild cognitive…
- APOE4-aware design, not carrier-specificNCT07208344Intravenous Infusion of Umbilical Cord Blood as an Adjunctive Treatment for Alzheimer's Disease
This trial is testing whether infusing stem-like cells from donated umbilical cord blood — on top of a standard Alzheimer's drug — is safe and shows early…
- Open to carriers, not 4-specificNCT07349706IMST for Dementia Risk Reduction
This trial tests whether a simple breathing-muscle workout, done at home for about 5 to 10 minutes a day over 8 weeks, can improve blood pressure, thinking,…
- Directly recruits APOE4 carriers with MCINCT07392723ALA-enriched Nutrition for Prevention of Cognitive Decline in APOE4 Older Adults
This trial tests whether a daily dose of alpha-linolenic acid (ALA), a plant-based omega-3 found in flaxseed oil, affects memory and thinking, and the health…
- Exclusively enrolls APOE4 carriersNCT07399171Study to Evaluate the Effect of HT-4253 for the Prevention of Alzheimer's Disease in APOE4 Carriers
This Phase 2 trial is testing an experimental drug called HT-4253 in APOE4 carriers who already show early amyloid buildup in their blood but have no dementia…
- Recruits APOE4/4 carriers, drug trialNCT07477431Levetiracetam for Persons at Risk for Alzheimer's Disease
This small pilot study tests whether very low doses of levetiracetam, an existing seizure drug, can calm overactive signaling in the brain's memory center.…
- Exclusively recruits APOE4 carriersNCT07516119Predicting Pre-dementia
This observational study is testing whether a multimodal prediction model — combining genetic risk scores, blood biomarkers, health record data, and wearable…
- APOE4 carriers explicitly excludedNCT07612449Percepta for Cognitive Optimization
This trial is testing a dietary supplement called Percepta, made from cat's claw bark extract and oolong tea extract, to see whether it improves cognitive…
- APOE4-focused registry, France residents onlyNCT07679906ALZEVIT: Nationwide Digital APOE ε4 Cohort for Early Alzheimer's Disease Prevention and Trial Readiness
ALZEVIT is an observational study in France, not a drug test. It builds a large registry by checking APOE genotype from a home saliva kit, then tracks memory,…
- 4/4 carriers excluded, one copy may qualifyNCT07688213A Study to Investigate the Safety and Effectiveness of SAR448851 in Participants With Early Alzheimer's Disease
This Phase 2 trial is testing SAR448851, a once-daily oral pill, in people with early Alzheimer's disease who have confirmed amyloid buildup in the brain.…
- Directly recruits APOE4 carriers onlyNCT07728175Effects of Sirolimus on Asymptomatic ApoE4 Carriers
This trial is testing whether sirolimus (rapamycin), an FDA-approved drug already used for other conditions, can improve blood flow and brain energy use in…
- Safety registry, APOE4 genotype trackedNCT07762092A Post Authorization Registry Study of Participants Treated With LEQEMBI
This is a post-approval registry study — not a clinical trial testing whether Leqembi works, but an ongoing safety watch now that the drug is in use.…
- Phoenix pick: randomised by APOE genotype; designed after a result in APOE4/4 carriersNCT07794670Randomized Study to Evaluate the Effect of Obicetrapib in Participants With Preclinical Alzheimer's Disease
This trial is testing whether obicetrapib, a 10 mg daily tablet, affects people with preclinical Alzheimer's, meaning brain changes without noticeable memory…
- Family genetics study, not APOE4-specificNCT00064870Alzheimer's Disease Genetics Study
This study collects blood or tissue samples from families with several members who have Alzheimer's or another dementia. Researchers want to find genes that…
- ALS family study, unrelated to APOE4NCT00317616The Pre-symptomatic Familial Amyotrophic Lateral Sclerosis (Pre-fALS) Study
This is an observational study, not a drug test. Researchers follow healthy people from families with inherited ALS (Lou Gehrig's disease) over time. They use…
- Aphasia diagnosis required, not APOE4-specificNCT00537004Language in Primary Progressive Aphasia
This study looks at how language and brain function change over time in people with primary progressive aphasia, a condition that gradually affects speech and…
- Rare inherited mutation families, not APOE4NCT00869817Dominantly Inherited Alzheimer Network (DIAN)
This is an observational study, meaning no drug or treatment is given. Researchers follow families with a rare inherited gene mutation that causes Alzheimer's,…
- Cell-donation research, not APOE4-specificNCT00874783Development of IPS from Donated Somatic Cells of Patients with Neurological Diseases
This study collects skin cells or a few hairs from people with neurodegenerative diseases, and from healthy donors, to turn them into stem cells in the lab.…
- Not APOE4-related; rare VCP gene studyNCT01353430Characterization of Inclusion Body Myopathy Associated With Paget's Disease of Bone and Frontotemporal Dementia (IBMPFD)
This is a research study, not a drug trial. Investigators are collecting blood, urine, family histories and questionnaires from families with a rare inherited…
- Huntington's study, not about APOE4NCT01574053Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort
Enroll-HD is an observational study, meaning no drug or treatment is given. It follows people with Huntington's disease, and their relatives and controls,…
- Rare disease registry, not APOE4-relevantNCT01793168Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
This is not a drug or treatment trial. It is a free patient registry run by Sanford Research in South Dakota. People with a rare disease, an undiagnosed…
- Not Alzheimer's, not APOE4-specificNCT01799915Natural History Study of Synucleinopathies
This is an observational study, not a drug test. Researchers follow people with synucleinopathies, such as Parkinson disease, Lewy body dementia, and multiple…
- Speech disorder imaging study, not APOE4-specificNCT01818661Longitudinal Multi-Modality Imaging in Progressive Apraxia of Speech
This study uses brain scans, including a PET scan with a tracer drug called AV-1451 that highlights tau protein, to follow people with progressive apraxia of…
- Observational only, genotype not requiredNCT02014246Genetic Characterization of Movement Disorders and Dementias
This is a genetic research study, not a treatment trial. Researchers at the National Institute on Aging are collecting blood or saliva samples from people with…
- Open to carriers, not 4-specificNCT02022943Alzheimer's Prevention Registry: A Program to Accelerate Enrollment Into Studies
This is not a treatment study. It is a registry, a contact list. People share their contact details and get emails about Alzheimer's prevention research and…
- Parkinsonism diagnosis required, not APOE4-specificNCT02194816Modifiable Variables in Parkinsonism (MVP)
This is an observational study, not a drug test. People with Parkinson's disease or related conditions fill out online questionnaires every six months for five…
- Observational study, genotype not mentionedNCT02302482Predictive Factors and Autonomy Level Change
This is an observational study, so nothing is being tested on patients. Researchers follow about 1,000 people with memory problems at a French memory clinic…
- Imaging study, genotype not specifiedNCT02414347F 18 T807 Tau PET Imaging of Alzheimer's Disease
This study uses a radioactive tracer called flortaucipir (F 18 T807) and PET brain scans to look for tau, a protein that clumps in Alzheimer's. Researchers…
- Imaging study, genotype not mentionedNCT02420470The Early Warning System for the Diabetic Encephalopathy
This study uses advanced brain MRI scans to look for early changes in the brains of people with type 2 diabetes or prediabetes. Researchers want to see whether…
- Diagnostic study, genotype not specifiedNCT02426398Developing a New EEG Method for the Early Diagnosis of Dementia
This study tests whether a standard EEG, a brain-wave recording already used in routine care, can help diagnose dementia. Researchers built new software to…
- Observational depression study, not APOE4-specificNCT02434393Characterizing Cognitive Decline in Late Life Depression: The ADNI Depression Project
This observational study follows older adults with late life depression to understand why some develop memory and thinking problems faster. Participants get…
- Imaging study, genotype not consideredNCT02649985PET Brain Imaging in Multiple Sclerosis, Alzheimer's Disease, and Other Neurological and Neuropsychiatric Diseases
This Phase 1 study uses specialized PET brain scans to look for microglial activation — a sign of brain inflammation — in people with multiple sclerosis and…
- Closed cohort, APOE4 not specifiedNCT02685969Brain Characterization of Amyloid Protein and Glucose Metabolism of ALFA Project Participants
This study uses two types of PET brain scans to measure amyloid protein buildup and glucose metabolism in cognitively healthy adults who are mostly children of…
- Diagnosed patients only, not APOE4-specificNCT02740634Molecular and Structural Imaging in Alzheimer's Disease: A Longitudinal Study
This study uses two brain scans, PiB for amyloid and AV-1451 for tau, to look at how those proteins build up in people already diagnosed with typical or…
- Parkinson patients only, not APOE4-specificNCT02763683Investigations of Dementia in Parkinson Disease
This study uses two kinds of brain scans, called PiB PET and VAT PET, to look at people who have Parkinson disease. The scans measure amyloid plaques and a…
- Not APOE4-specific; for existing neurologic damageNCT02795052Neurologic Stem Cell Treatment Study
This study takes a person's own bone marrow stem cells and delivers them through a vein and the lower nose. Researchers want to see whether neurologic function…
- Observational study, genotype not specifiedNCT02800395Influence of Oxidative Stress and Nutrition Biomarkers on the Cognitive Decline Evolution in Alzheimer Disease
This French study follows people with memory complaints to see whether blood markers of oxidative stress (cell wear and tear) and nutrition can predict how…
- Observational only, genotype not relevantNCT02811653Motor Slowing and Its Lesion-related Correlates in Alzheimer's Disease
This trial is studying the relationship between movement slowness and brain changes visible on MRI in people with Alzheimer's disease and related conditions.…
- Unrelated to APOE4 or Alzheimer'sNCT02855476HDClarity: a Multi-site Cerebrospinal Fluid Collection Initiative to Facilitate Therapeutic Development for Huntington's Disease
HDClarity is collecting cerebrospinal fluid and blood samples from people at various stages of Huntington's disease, plus healthy controls, across multiple…
- FTD imaging study, not APOE4-focusedNCT02945774Molecular Neuroimaging of Neuroinflammation in Neurodegenerative Dementias
This study uses a brain scan (PET/MRI) with a tracer called FEPPA to look for inflammation in the brains of people with frontotemporal dementia, and to see how…
- Not Alzheimer's-focused, APOE4 not addressedNCT02964637Diagnosing Frontotemporal Lobar Degeneration
This is an observational study, meaning no drug or treatment is given. Researchers are working to build better diagnostic tools, such as brain imaging and…
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Educational, not medical advice. Trial decisions belong between you and your physician.