Recruiting now.
806 APOE4-relevant Alzheimer’s trials are recruiting participants right now. Each one translated into plain English, with our read on what it means for an APOE4 carrier.
- Observational only, China-based populationNCT03653156China Cognition and Aging Study
This is a large observational study based in China, not a drug or treatment trial. Researchers are building a national database by following thousands of…
- APOE4 carriers explicitly includedNCT04575337Study on Biomarkers for Early Diagnosis of Alzheimer's Disease
This is an observational study based in China that is tracking elderly people over five years to identify early biological markers of Alzheimer's disease.…
- Requires at least one APOE4 alleleNCT05245903Passive Sensor Identification of Digital Biomarkers to Assess Effects of Orally Administered Nicotinamide Riboside
This trial is testing whether a supplement called nicotinamide riboside (a form of vitamin B3) produces measurable changes in brain energy metabolism in people…
- Directly recruits APOE4 carriersNCT05599425Health Behavior Change in Midlife Adults at Risk for Alzheimer's Disease
This trial tests two versions of a healthy-living education program aimed at helping middle-aged adults make lasting lifestyle changes — better diet, more…
- APOE4 carriers explicitly namedNCT05649514Sleep Impairment in Subjects at Risk of Developing Alzheimer's Disease
This study is observing whether poor sleep is linked to cognitive decline in people at early risk of Alzheimer's. Participants undergo sleep studies, cognitive…
- APOE4 carriers central to studyNCT06335836The Effects of Social Isolation and Social Interaction on the Risk of Dementia Progression and Brain Function in SCD (Subjective Cognitive Decline, SCD)
This trial is studying how social isolation and social interaction affect the brain and the risk of progressing from subjective cognitive decline to more…
- APOE4 genotyped, non-drug device trialNCT06467253Comparison of Two Non-invasive Neuromodulation Techniques as Synergistic Therapy to Cognitive Stimulation in Amnestic Mild Cognitive Impairment (aMCI)
This trial is testing two types of non-invasive brain stimulation — repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current…
- Observational only, genotype not studiedNCT06818409Is the CRP-Albumin-Lymphocyte (CALLY) Index Effective in Predicting Postoperative Delirium in Geriatric Patients Undergoing Hip Fracture Surgery
This study is testing whether a simple blood-test index called the CALLY Index, which combines three routine lab values, CRP, albumin, and lymphocyte count,…
- Actively recruits APOE4 carriersNCT07007208Biomarkers of the Locus Coeruleus Nucleus: Links With Early Tau Pathology, Cognition and Alzheimer's Disease Risk
This trial is studying a brain region called the locus coeruleus, which may show early signs of tau protein buildup before other areas affected in Alzheimer's.…
- Genotype-stratified, carriers likely eligibleNCT07027072Study to Evaluate the Efficacy and Safety of KDS2010 in Patients With Alzheimer's Disease With Mild Cognitive Impairment and Mild Dementia Due to Alzheimer's Disease
This trial is testing KDS2010, an experimental oral drug taken once daily, in people who have early Alzheimer's-related memory problems — either mild cognitive…
- APOE4-aware design, not carrier-specificNCT07208344Intravenous Infusion of Umbilical Cord Blood as an Adjunctive Treatment for Alzheimer's Disease
This trial is testing whether infusing stem-like cells from donated umbilical cord blood — on top of a standard Alzheimer's drug — is safe and shows early…
- Exclusively recruits APOE4 carriersNCT07516119Predicting Pre-dementia
This observational study is testing whether a multimodal prediction model — combining genetic risk scores, blood biomarkers, health record data, and wearable…
- 4/4 carriers excluded, one copy may qualifyNCT07688213A Study to Investigate the Safety and Effectiveness of SAR448851 in Participants With Early Alzheimer's Disease
This Phase 2 trial is testing SAR448851, a once-daily oral pill, in people with early Alzheimer's disease who have confirmed amyloid buildup in the brain.…
- Observational only, genotype not requiredNCT02014246Genetic Characterization of Movement Disorders and Dementias
This is a genetic research study, not a treatment trial. Researchers at the National Institute on Aging are collecting blood or saliva samples from people with…
- Imaging study, genotype not consideredNCT02649985PET Brain Imaging in Multiple Sclerosis, Alzheimer's Disease, and Other Neurological and Neuropsychiatric Diseases
This Phase 1 study uses specialized PET brain scans to look for microglial activation — a sign of brain inflammation — in people with multiple sclerosis and…
- Closed cohort, APOE4 not specifiedNCT02685969Brain Characterization of Amyloid Protein and Glucose Metabolism of ALFA Project Participants
This study uses two types of PET brain scans to measure amyloid protein buildup and glucose metabolism in cognitively healthy adults who are mostly children of…
- Observational only, genotype not relevantNCT02811653Motor Slowing and Its Lesion-related Correlates in Alzheimer's Disease
This trial is studying the relationship between movement slowness and brain changes visible on MRI in people with Alzheimer's disease and related conditions.…
- Unrelated to APOE4 or Alzheimer'sNCT02855476HDClarity: a Multi-site Cerebrospinal Fluid Collection Initiative to Facilitate Therapeutic Development for Huntington's Disease
HDClarity is collecting cerebrospinal fluid and blood samples from people at various stages of Huntington's disease, plus healthy controls, across multiple…
- Parkinson's trial, genotype not relevantNCT03025334tDCS on Parkinson's Disease Cognition
This trial is testing whether a non-invasive brain stimulation technique called high-definition transcranial direct current stimulation (HD-tDCS) can improve…
- Unrelated to APOE4 or Alzheimer'sNCT03047369The Myelin Disorders Biorepository Project
This is a biorepository project, not a treatment trial. Researchers are collecting medical records and biological samples (like blood or tissue) from people…
- Open to carriers, not 4-specificNCT03082755Nighttime Agitation and Restless Legs Syndrome in People With Alzheimer's Disease
This Phase 4 trial is testing whether gabapentin enacarbil (Horizant), a drug already approved for restless legs syndrome, can reduce nighttime agitation in…
- Genotype-blind, not APOE4-specificNCT03135327Clinical Applications of Advanced Ophthalmic Imaging
This study is testing whether advanced eye-imaging tools — including OCT scans and retinal imaging — can detect changes in the eyes of people with conditions…
- AD comparison group, not APOE4-focusedNCT03217396Biomarkers of Synaptic Damage in Multiple Sclerosis
This study is collecting blood and spinal fluid samples from people with multiple sclerosis, ALS, Alzheimer's disease, and Parkinson's disease to look for…
- Unrelated conditions, not APOE4-relevantNCT03225144Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
This is a screening and natural history study at the NIH, not a treatment trial. Researchers are enrolling people already diagnosed with ALS, frontotemporal…
- Explicitly lists APOE4-positive carriersNCT03233646Retinal Imaging in Neurodegenerative Disease
This study uses non-invasive eye-imaging technology — optical coherence tomography (OCT) and wide-field retinal photography — to look for early signs of…
- Unrelated to APOE4 or Alzheimer'sNCT03434548IMarkHD: in Vivo Longitudinal Imaging of HD Pathology
This trial uses PET and MRI brain scans to track how Huntington's disease changes the brain over three years, from before symptoms appear through later stages.…
- Observational only, genotype not relevantNCT03552926Constitution of a Clinico-radiological Database and a Biobank for Patients With Lacunar Infarcts
This is an observational study — no drug or device is being tested. Researchers in France are building a database and tissue bank from patients who have had a…
- Open to at-risk groups, genotype not specifiedNCT03592563CUHK Brain Health Longitudinal Study
This is a long-term observational study at the Chinese University of Hong Kong that is tracking people with brain diseases, people at high risk for them, and…
- Device study, genotype not consideredNCT03614962Warmth and Transcutaneous Electrical Nerve Stimulation (TENS) in Improving Cognitive Functions in People with Dementia
This trial tests whether a special hat that delivers both gentle warmth and mild electrical stimulation (TENS) to acupuncture points on the head can improve…
- Observational only, genotype not specifiedNCT03621839New CSF Biomarkers for Alzheimer's Disease
This study is collecting leftover cerebrospinal fluid (CSF) — the fluid drawn during routine lumbar punctures for dementia diagnosis — to test new biological…
- Open registry, genotype not requiredNCT03638583Alzheimer Prevention Trials (APT) Webstudy
The APT Webstudy is not a treatment trial. It is an online registry that tracks cognitive health over time in people 50 and older who do not have dementia. The…
- FAD gene study, not APOE4-relevantNCT03657732The Chinese Familial Alzheimer's Network
This is a Chinese registry and research network, not a treatment trial. Researchers are enrolling families with hereditary Alzheimer's disease caused by known…
- Open to carriers, not 4-specificNCT03657745Alzheimer's Disease Treatment With Combination of 40Hz Light and Cognitive Therapy
This trial is testing an iPad app called AlzLife that flashes light at 40 times per second (40Hz) combined with cognitive exercises. The idea is that this…
- Open to carriers, genotype not trackedNCT03665831Deep TMS for Comorbid Depression and Cognitive Impairment in Older Adults
This trial is testing whether a non-invasive brain stimulation device called deep TMS, using a specialized H1 coil aimed at the left prefrontal cortex, can…
- Open to carriers, not 4-specificNCT03672266Studies of Brain and Body Interaction
This study records biological signals from the nervous system while participants perform everyday movements like walking and pointing, and practice slow…
- Observational registry, genotype not relevantNCT03687112National Bank Alzheimer
This is an observational registry, not a treatment trial. France's National Alzheimer Database collects demographic, clinical, and diagnostic data from…
- Open to carriers, genotype not requiredNCT03799991Vestibular Therapy in Alzheimer's Disease
This trial is testing whether vestibular physical therapy — exercises that retrain the inner ear balance system — can reduce falls in people with mild to…
- Open to carriers, genotype not consideredNCT03810794Clinical Evaluation on the Therapeutic Effect of Acupuncture Treatment for Alzheimer's Disease
This trial is testing whether adding acupuncture to the standard Alzheimer's drug donepezil works better than donepezil alone. Researchers will track cognitive…
- Not relevant to APOE4 carriersNCT03836950rTMS to Improve Cognition in Parkinson's
This trial is testing repetitive transcranial magnetic stimulation, or rTMS, a non-invasive device that delivers magnetic pulses to the brain, to see whether…
- Open to carriers, genotype ignoredNCT03840083Sleep-dependent Learning in Aging
This study is exploring how sleep helps the brain consolidate memories, and whether age-related memory problems are tied to changes in sleep, changes in memory…
- Observational only, genotype not specifiedNCT03851523Longitudinal Study for the Characterization of the Phases of Subjective Perception of Cognitive Decline and Mild Cognitive Impairment of Alzheimer's Disease.
This observational study tracks people over time to understand the very earliest signs of Alzheimer's disease — specifically, what happens when someone feels…
- Open to carriers, genotype not requiredNCT03860857Biomarker Exploration in Aging, Cognition and Neurodegeneration
This observational study is tracking brain changes in people 60 and older who currently have normal cognition. Researchers are using MRI, amyloid PET, tau PET,…
- Diagnosis-specific, genotype not a factorNCT03887481Targeting Language-specific and Executive-control Networks With Transcranial Direct Current Stimulation in Logopenic Variant PPA
This trial tests whether brain stimulation using a weak electrical current (called tDCS) delivered to specific language and memory areas of the brain, combined…
- Observational only, genotype not addressedNCT03894254Predictive Factors of Autonomy Loss in Real-life Cohort
This French observational study is not testing a drug or treatment. It is building a long-term database of about 5,400 patients with Alzheimer's disease or…
- Late-stage dementia care, not preventionNCT03926520Electroconvulsive Therapy (ECT) for Agitation in Dementia (AD)
This trial is testing whether electroconvulsive therapy (ECT) — brief, controlled electrical stimulation of the brain — can safely reduce severe agitation in…
- Observational only, not APOE4-specificNCT03934957Hamburg City Health Study - a German Cohort Study
The Hamburg City Health Study is a large, long-term observational study following thousands of German residents aged 45 to 74. Researchers are tracking who…
- Not relevant to APOE4 carriersNCT03945968The Role of Concomitant Diseases in Postoperative Complications Risk Stratification.
This study is looking at how pre-existing conditions — including Alzheimer's disease — affect the risk of complications after abdominal surgery. Researchers…
- Observational only, genotype not addressedNCT03946930Cognitive Decline in AD
This is an observational cohort study, not a treatment trial. Researchers are following older adults already diagnosed with Alzheimer's disease to identify…
- Observational only, genotype not relevantNCT03987633EMPOWER-1: A Multi-site Clinical Cohort Research Study to Reduce Health Inequality
EMPOWER-1 is an observational cohort study based in the UK testing whether commonly prescribed drugs actually work as expected across different ethnic and…
- No relevance to APOE4 carriersNCT04045600Refinements of Functional Communication Training
This trial is testing three versions of a behavioral therapy called Functional Communication Training, or FCT, which teaches children with severe problem…
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Educational, not medical advice. Trial decisions belong between you and your physician.