NCT07679906 · RECRUITING
ALZEVIT: Nationwide Digital APOE ε4 Cohort for Early Alzheimer's Disease Prevention and Trial Readiness
ALZEVIT is an observational study in France, not a drug test. It builds a large registry by checking APOE genotype from a home saliva kit, then tracks memory, thinking, brain scans and risk factors over time. The aim is to understand how different genotypes progress. No phase applies because nothing is being given.
You may qualify if
- Participants who sign the electronic Informed Consent form.
- Adults aged over 45 years old (inclusive) at the time of consent.
- Participants residing in France.
- Participants able to read and understand the study information in French or with the help of a legal representative.
- Participants are capable of electronically signing the consent form.
- Participants affiliated with the French national health insurance system.
- Participants with access to the internet and a valid email address.
- Participants can self-collect and return a saliva sample using a provided kit (ORAcollect® Dx device).
You're excluded if
- Participants who do not sign the Informed Consent form.
- Participants who are unable to read or understand French.
- Participants younger than 45 years at the time of consent.
- Participants with known cognitive impairments, severe dementia, or psychiatric conditions that prevent informed consent.
- Participants with a documented substance use disorder (alcohol or drug dependence) within the past 24 months.
- Participants who cannot be reliably contacted by email or phone.
- Participants previously enrolled in the ALZEVIT study or its pilot phase.
- Participants who are legally protected adults or under guardianship, curatorship, or judicial/administrative custody.
- Participants whose physical condition does not allow them to perform the tasks required by the study.
- Participants who, in the judgment of the Investigator, are unlikely to comply with study procedures.
- Participants who are study staff (investigators, sub-investigators, coordinators, assistants) or their immediate family members.
- Participants who are incarcerated or deprived of liberty by judicial or administrative decision.
- Participants with any disease or condition that, in the opinion of the Investigator, would compromise participation or safety.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-09-02