NCT07854327 · RECRUITING
Restoring Cervical Lymphatic Drainage in Alzheimer's Disease
This small pilot study tests a microsurgery that connects tiny lymphatic vessels in the neck to nearby veins. Researchers want to see if it is feasible and safe, and whether it changes brain scans, blood markers, or thinking tests. Only five people with Alzheimer's will take part. It is an early exploratory study, not designed to show real benefit.
You may qualify if
- Diagnosis of Alzheimer's disease according to NIA-AA 2024 criteria.
- Not eligible for other disease-modifying therapies.
- Ability to personally provide written informed consent after clinical evaluation -of decisional capacity.
You're excluded if
- Coagulopathy or active infection of the head and neck region.
- Prior extensive cervical lymph node dissection or radiotherapy.
- Uncontrolled systemic disease or contraindication to general anesthesia.
- Participation in another interventional trial within the previous 3 months.
- Known hypersensitivity or allergy to indocyanine green.
- Evidence of alternative or concomitant causes of cognitive decline other than Alzheimer's disease, such as subdural hematoma, primary or metastatic brain malignancy, or normal-pressure hydrocephalus.
- Current or recent treatment with immunosuppressive or immunomodulatory therapy within the previous 3 months.
- Clinically significant infectious disease within the previous 6 months.
- Severe psychiatric disorder that could interfere with cognitive assessment or study participation.
- Pregnancy or breastfeeding.
- End-stage malignant disease with an estimated life expectancy of less than 6 months.
- History indicative of systemic autoimmune disease.
- Inability to personally provide valid informed consent.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-10-02