NCT01799915 · RECRUITING
Natural History Study of Synucleinopathies
This is an observational study, not a drug test. Researchers follow people with synucleinopathies, such as Parkinson disease, Lewy body dementia, and multiple system atrophy, plus people with early signs like blood pressure drops on standing or acting out dreams. They track symptoms and biological markers over time to learn how these diseases progress. No phase was listed.
You may qualify if
- Both male and female patients will be included
- Aged 18 or over
- Referred to any of the participating consortium sites with orthostatic intolerance, defined as symptoms of dizziness or lightheadedness in the standing position that disappear when supine.
You're excluded if
- Diabetes according to the American Diabetes Association criteria
- Congestive heart failure
- Lupus or other collagen vascular disease
- Systemic illness thought to be responsible for the orthostatic intolerance
- Drug-induced orthostatic hypotension (i.e., the use of alpha-blockers, diuretics, tricyclic antidepressants or others thought by the investigator to play an important role in the patient's orthostatic hypotension)
- Isolated vasovagal syncope
- Inability to comply with the protocol, e.g. uncooperative attitude, inability to return for follow-up visits, and unlikelihood of completing the study.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-06-10