Trials in Minnesota.
65 APOE4-relevant Alzheimer’s trials run in Minnesota — 26 of them recruiting. Each one translated into plain English, with our read on what it means for an APOE4 carrier.
- Non-carriers only, not for APOE4NCT00574132Bapineuzumab in Patients With Mild to Moderate Alzheimer's Disease (ApoE4 Non-Carrier)
This trial tested bapineuzumab, an infused antibody designed to bind and clear beta amyloid from the brain, against a placebo. It measured whether it helped…
- Drug trial for diagnosed APOE4 carriersNCT00575055Bapineuzumab in Patients With Mild to Moderate Alzheimer's Disease (ApoE4 Carrier)
This trial tested whether bapineuzumab, an antibody given by infusion that helps clear beta amyloid from the brain, could affect thinking and daily function in…
- Built exclusively for APOE 4/4 carriersNCT02565511A Study of CAD106 and CNP520 Versus Placebo in Participants at Risk for the Onset of Clinical Symptoms of Alzheimer's Disease
This trial tested two investigational drugs, CAD106 (a vaccine-like immunotherapy targeting amyloid) and CNP520 (a small molecule targeting amyloid…
- Built specifically for APOE4 carriersNCT03131453A Study of CNP520 Versus Placebo in Participants at Risk for the Onset of Clinical Symptoms of Alzheimer's Disease
This trial tested CNP520, a drug designed to reduce amyloid buildup in the brain, against a placebo in cognitively normal older adults at elevated risk for…
- APOE4 carriers explicitly welcomedNCT04468659AHEAD 3-45 Study: A Study to Evaluate Efficacy and Safety of Treatment With Lecanemab in Participants With Preclinical Alzheimer's Disease and Elevated Amyloid and Also in Participants With Early Preclinical Alzheimer's Disease and Intermediate Amyloid
This Phase 3 trial is testing lecanemab, an anti-amyloid antibody drug, in people who are cognitively normal but have early amyloid buildup in their brains —…
- Enrolled carriers, prior data unfavorableNCT00348309Rosiglitazone (Extended Release Tablets) As Adjunctive Therapy For Subjects With Mild To Moderate Alzheimer's Disease
This trial tested whether rosiglitazone extended release, a diabetes drug, could improve thinking and memory in people already taking donepezil for mild to…
- APOE4 stratified, suggests less benefitNCT00428090Rosiglitazone (Extended Release Tablets) As Monotherapy In Subjects With Mild To Moderate Alzheimer's Disease
This Phase 3 trial tested rosiglitazone XR, a diabetes drug already approved for type 2 diabetes, as a standalone treatment for mild to moderate Alzheimer's…
- Cancer trial, not for healthy carriersNCT01227954Avoiding the Hippocampus During Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases
This trial tests whether a more precise form of whole-brain radiation can spare the hippocampus, the brain's memory center, in people whose cancer has spread…
- Huntington's study, not about APOE4NCT01574053Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort
Enroll-HD is an observational study, meaning no drug or treatment is given. It follows people with Huntington's disease, and their relatives and controls,…
- Not Alzheimer's, not APOE4-specificNCT01799915Natural History Study of Synucleinopathies
This is an observational study, not a drug test. Researchers follow people with synucleinopathies, such as Parkinson disease, Lewy body dementia, and multiple…
- Speech disorder imaging study, not APOE4-specificNCT01818661Longitudinal Multi-Modality Imaging in Progressive Apraxia of Speech
This study uses brain scans, including a PET scan with a tracer drug called AV-1451 that highlights tau protein, to follow people with progressive apraxia of…
- Amyloid-focused, drug did not succeedNCT02008357Clinical Trial of Solanezumab for Older Individuals Who May be at Risk for Memory Loss
This Phase 3 trial tested solanezumab, an antibody drug given by IV infusion, in cognitively normal older adults who already had amyloid buildup in their…
- Not Alzheimer's-related; no APOE4 focusNCT02180139tDCS in Cervical Dystonia
This study tests whether brief, painless electrical stimulation of the brain, called tDCS, can ease symptoms of cervical dystonia, a condition that causes…
- Not Alzheimer's-focused, not APOE4-specificNCT02327845Phenotype, Genotype & Biomarkers in ALS and Related Disorders
This is an observational study, so nothing is being tested as a treatment. Researchers are looking at how the genes and symptoms of ALS and related conditions,…
- Lymphoma study, not Alzheimer's-relatedNCT02633111DNA Sequencing-Based Monitoring of Minimal Residual Disease to Predict Clinical Relapse in Aggressive B-cell Non-Hodgkin Lymphomas
This study looks at whether a blood test can spot aggressive B-cell lymphoma coming back after first-round chemotherapy. The test reads tumor DNA left in the…
- Diagnosed patients only, not APOE4-specificNCT02740634Molecular and Structural Imaging in Alzheimer's Disease: A Longitudinal Study
This study uses two brain scans, PiB for amyloid and AV-1451 for tau, to look at how those proteins build up in people already diagnosed with typical or…
- Cancer patients only, genotype not specifiedNCT03016741Cognitive Effects of Androgen Receptor Directed Therapies for Advanced Prostate Cancer
This trial is studying whether prostate cancer hormone therapies — specifically abiraterone acetate and enzalutamide — affect brain structure and cognitive…
- Unrelated to APOE4 or Alzheimer'sNCT03047369The Myelin Disorders Biorepository Project
This is a biorepository project, not a treatment trial. Researchers are collecting medical records and biological samples (like blood or tissue) from people…
- Not relevant; Alzheimer's patients excludedNCT03313011The Neurobiology of Two Distinct Types of Progressive Apraxia of Speech
This study uses brain imaging and clinical testing to tell apart two types of progressive apraxia of speech, a rare condition where speech slowly becomes…
- Not relevant: ALS records study, no APOE4NCT03489278Clinical Procedures to Support Research in ALS
This study uses information already in the medical records of people with ALS and related conditions to learn more about those diseases. It tests no drug or…
- Open to carriers, not 4-specificNCT03507257Longitudinal Early-onset Alzheimer's Disease Study Protocol
LEADS is an observational study, not a treatment trial. Researchers are tracking how early-onset Alzheimer's and related conditions progress over time in…
- Women 60+, APOE4 not mentionedNCT03821857Sex-Specific Effects of Endocrine Disruption on Aging and Alzheimer's Disease
This study looks at whether a woman's ovarian hormones are linked to how the brain ages and to Alzheimer's risk. Participants get a brain scan using…
- Not APOE4-related, movement disorder focusNCT03924414Trial of Parkinson's And Zoledronic Acid
This trial is testing whether a single IV infusion of zoledronic acid, a bone-strengthening drug already approved for osteoporosis, can reduce fractures in…
- Late-stage dementia care, not preventionNCT03926520Electroconvulsive Therapy (ECT) for Agitation in Dementia (AD)
This trial is testing whether electroconvulsive therapy (ECT) — brief, controlled electrical stimulation of the brain — can safely reduce severe agitation in…
- Imaging study, genotype not specifiedNCT04099823MR Evaluation of Cerebrospinal Fluid (CSF) Dynamics
This study tests an MRI method that tracks how cerebrospinal fluid, the fluid cushioning the brain, flows. Researchers want to see if it can help diagnose and…
- Open to carriers, not 4-specificNCT04148391NYX-458 in Subjects With Mild Cognitive Impairment or Mild Dementia Due to Parkinson's Disease or Lewy Body Dementia (Cognition, Memory, Attention, Thinking)
This trial is testing NYX-458, an experimental oral drug, against a placebo in people who have mild cognitive impairment or mild dementia caused by Parkinson's…
- Open to carriers, genotype not trackedNCT04171323The Active Mind Trial: An Adaptive Randomized Trial to Improve Function and Delay Dementia
This trial is testing different combinations of computerized brain exercises to see which combination best helps older adults with mild cognitive impairment…
- Open to carriers, not 4-specificNCT04262206Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults
PREVENTABLE is a large Phase 4 trial testing whether atorvastatin 40 mg — a common cholesterol-lowering statin — can reduce the combined risk of death,…
- FTLD-focused, not APOE4-relevantNCT04363684ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)
This is a large North American research registry and natural history study tracking people with frontotemporal lobar degeneration (FTLD) and related conditions…
- Not APOE4-related; FTD gene families onlyNCT04516499Neurofilament Surveillance Project (NSP)
This is a blood-collection study, not a drug test. Researchers are measuring neurofilament, a protein that can signal nerve cell damage, in people from…
- Symptomatic patients only, not APOE4-specificNCT04785300ALSENLITE: Senolytics for Alzheimer's Disease
This trial gives people with mild cognitive impairment or early-to-moderate Alzheimer's two pills together, dasatinib and quercetin. These are called…
- Observational only, genotype not specifiedNCT04916210Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY
The DISCOVERY study is an observational study — no drug or treatment is being tested. Researchers are following stroke survivors over time, collecting…
- Kidney-memory observation study, not APOE4-specificNCT04975464BRINK (BRain In Kidney Disease) Memory Study 2.0
BRINK 2.0 is an observational study. It tests no drug or treatment. Researchers give memory, thinking, and daily-activity tests to people with and without…
- Genetic study, carriers likely relevantNCT05010603Late Onset Alzheimer's Disease
This study collects blood samples and runs memory and thinking tests to look for genes that influence who gets Alzheimer's disease. It focuses on families…
- Drug trial, genotype not specified, ARIA riskNCT05026866A Donanemab (LY3002813) Study in Participants With Preclinical Alzheimer's Disease (TRAILBLAZER-ALZ 3)
This trial tests donanemab, an anti-amyloid antibody given by infusion, against a placebo in people with no memory or thinking problems but signs of amyloid in…
- Not relevant to APOE4 carriersNCT05184569Veri-T: A Trial of Verdiperstat in Patients With svPPA Due to TDP-43 Pathology
This Phase 1 trial is testing whether verdiperstat, a drug that may reduce harmful inflammation in brain cells, is safe and tolerable for people with semantic…
- Imaging study, genotype not requiredNCT05361382Head-to-Head Harmonization of Tau Tracers in Alzheimer's Disease
This trial is comparing two different PET scan tracers — Flortaucipir and MK-6240 — that are used to measure tau tangles in the brain, a hallmark of…
- Not a participant trial, staff onlyNCT05530590Minnesota Inclusive LTSS for LGBTQ Seniors
This trial tests two versions of a workforce training program for nursing homes and assisted living facilities in Minnesota. The goal is to teach staff how to…
- Open to carriers, not 4-specificNCT05531656A Study to Evaluate the Safety and Efficacy of CT1812 in Early Alzheimer's Disease
This trial is testing CT1812, an experimental drug, in people with early Alzheimer's disease — either mild cognitive impairment or mild dementia confirmed by…
- Closed follow-up, genotype not a factorNCT05532657ACHIEVE Brain Health Follow-Up Study
This trial is a 3-year follow-up to a completed study called ACHIEVE. It is tracking whether older adults who received hearing aids earlier show less cognitive…
- Community care study, genotype not relevantNCT05550727The PorchLight Project
The PorchLight Project is testing a training program for volunteer Senior Companions who visit and support older adults with memory loss. The goal is to see…
- Caregiver support, genotype irrelevantNCT05779839A Study of Caregiver Connections Via Technology in Dementia
This trial is testing whether a technology-based matching program can connect dementia caregivers with peer support partners more effectively than random…
- Observational only, genotype not requiredNCT05826457North American Prodromal Synucleinopathy Consortium Stage 2
This study is building a research foundation — enrolling people with REM sleep behavior disorder (RBD) and healthy controls to prepare for future trials of…
- Observational study, not APOE4-specificNCT06284213Biomarkers for Vascular Contributions to Cognitive Impairment and Dementia Consortium
This is an observational study, not a drug test. Researchers will collect brain scans and blood samples from about 1,800 older adults, then follow them over…
- Open to carriers, not 4-specificNCT06340659Concurrent Aerobic Exercise and Cognitive Training to Prevent Alzheimer's in At-risk Older Adults (The Exergames Telerehabilitation Study)
This trial compares two home-based, telehealth exercise programs for older adults who notice they are forgetting things more than before. One group does…
- No Alzheimer's or APOE4 relevanceNCT06413173Remotely Supervised tDCS+ for Complex Attention in mTBI (Cognetric)
This trial tests whether a non-invasive brain stimulation technique called tDCS, delivered at home and combined with cognitive training exercises, can improve…
- Observational study, genotype not relevantNCT064674615-HT RBD REM Sleep Behavior Disorder
This study is investigating whether a specific type of REM sleep behavior disorder — triggered by SSRI antidepressants rather than arising on its own — might…
- Not about APOE4; requires TTR variantNCT06563895Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant
This trial tests whether a daily pill called acoramidis can delay or prevent heart or nerve damage in people who carry an inherited TTR gene variant but have…
- Drug trial, APOE4 handling not statedNCT06653153A Study of Remternetug (LY3372993) in Early Alzheimer's Disease (TRAILRUNNER-ALZ 3)
This trial tests remternetug, an anti-amyloid antibody drug, against a placebo. It measures how long it takes for memory, thinking, or daily-function problems…
- Open to MCI group, genotype not specifiedNCT06897670Identifying Cerebral Hemodynamic Patterns in Mood Disorders and Mild Cognitive Impairment: A Functional Near-Infrared Spectroscopy (fNIRS) Study
This study uses a noninvasive brain scanner called fNIRS — essentially a lightweight headband that tracks blood flow and oxygen in the brain — to compare brain…
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Educational, not medical advice. Trial decisions belong between you and your physician.