NCT04975464 · ACTIVE NOT RECRUITING
BRINK (BRain In Kidney Disease) Memory Study 2.0
BRINK 2.0 is an observational study. It tests no drug or treatment. Researchers give memory, thinking, and daily-activity tests to people with and without chronic kidney disease, then follow them for up to four more years. The goal is to compare how often memory problems occur and to find risk factors. No phase applies because nothing is being tested.
Eligibility criteria
Inclusion Criteria for CKD Participants: 1. In stages 3b-5 of chronic kidney disease (GFR ≤ 60 ± 5 ml/min/1.73m2) at the first baseline visit in BRINK 1.0. 2. Able to complete an approximately 90 minute cognitive and physical testing battery. 3. Able to sign the informed consent, or allow a caregiver, relative, surrogate, or witness to sign the informed consent if participant is unable to do so. Inclusion Criteria for non-CKD Participants: 1. GFR ≥ 60 ± 5 ml/min/1.73m2 at the first baseline visit in BRINK 1.0. 2. Able to complete an approximately 90 minute cognitive and physical testing battery. 3. Able to sign the informed consent, or allow a caregiver, relative, surrogate, and/or witness to sign the informed consent if participant is unable to do so. Exclusion Criteria: Exclusion Criteria for CKD and non-CKD Participants: 1. Acute psychiatric illness that would impede cognitive testing 2. Active chemical dependence 3. Legally blind or unable to complete cognitive tests due to visual loss or deafness
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-11-04