NCT03821857 · Phase 4 · RECRUITING
Sex-Specific Effects of Endocrine Disruption on Aging and Alzheimer's Disease
This study looks at whether a woman's ovarian hormones are linked to how the brain ages and to Alzheimer's risk. Participants get a brain scan using flortaucipir, a tracer that shows tau, a protein tied to Alzheimer's. It is a Phase 4 trial, meaning the tracer is already approved, and it is used here as a research tool.
Eligibility criteria
Mayo Clinic Rochester- Inclusion Criteria: * Women who previously participated in this study * Currently aged 60 years and older * More than six months post chemotherapy or major surgery requiring general anesthesia * Willing and able to sign informed consent Exclusion Criteria: * Not able to read and speak English * In hospice * Claustrophobic * If undergoing Tau imaging, cannot have QT Prolongation Mayo Clinic Jacksonville- Inclusion Criteria: * African American Women * Currently aged 60 years and older * More than six months post chemotherapy or major surgery requiring general anesthesia * Willing and able to sign informed consent Exclusion Criteria: * Not able to read and speak English * In hospice * Claustrophobic * If undergoing Tau imaging, cannot have QT Prolongation
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-11-24