NCT04099823 · RECRUITING
MR Evaluation of Cerebrospinal Fluid (CSF) Dynamics
This study tests an MRI method that tracks how cerebrospinal fluid, the fluid cushioning the brain, flows. Researchers want to see if it can help diagnose and better understand conditions like hydrocephalus and Alzheimer's. It involves imaging only, no drug. It has no phase because it tests a scan, not a treatment.
You may qualify if
- A healthy control will be defined as an otherwise healthy person who does not have a medical condition that affects brain function or have problems with concentration, memory, balance, or coordination.
- Patients who have a suspected diagnosis of altered CSF dynamics including but not limited to normal pressure hydrocephalus will be referred to Dr. Cogswell by their care team to be included in the study. Conditions of altered CSF dynamics include obstructive and non-obstructive hydrocephalus and may be associated with headaches and/or decreased cognitive function.
- Similarly, patients with impaired cognitive function including but not limited to Alzheimer's disease will be referred to Dr. Cogswell by their care team to be included in the study.
You're excluded if
- Subjects with non-MRI compatible devices
- required sedation
- women who may be pregnant will be excluded.
- The first 10 subjects with normal pressure hydrocephalus will not have previously been shunted.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-01-06