Lewy body dementia trials.
45 Lewy body dementia trials, curated for APOE4 carriers — 25 of them recruiting. Each one translated into plain English, with our read on what it means for an APOE4 carrier.
- Explicitly lists APOE4-positive carriersNCT03233646Retinal Imaging in Neurodegenerative Disease
This study uses non-invasive eye-imaging technology — optical coherence tomography (OCT) and wide-field retinal photography — to look for early signs of…
- Open to carriers, not 4-specificNCT03672266Studies of Brain and Body Interaction
This study records biological signals from the nervous system while participants perform everyday movements like walking and pointing, and practice slow…
- Not APOE4-related, movement disorder focusNCT03924414Trial of Parkinson's And Zoledronic Acid
This trial is testing whether a single IV infusion of zoledronic acid, a bone-strengthening drug already approved for osteoporosis, can reduce fractures in…
- Genotype collected, not carrier-specificNCT04117178Monitoring Anti-Dementia Drugs by Serum Levels
This Phase 4 trial is testing whether measuring the actual blood levels of two common dementia drugs, donepezil and memantine, helps doctors fine-tune the dose…
- Open to carriers, not 4-specificNCT04148391NYX-458 in Subjects With Mild Cognitive Impairment or Mild Dementia Due to Parkinson's Disease or Lewy Body Dementia (Cognition, Memory, Attention, Thinking)
This trial is testing NYX-458, an experimental oral drug, against a placebo in people who have mild cognitive impairment or mild dementia caused by Parkinson's…
- Unrelated to APOE4 or Alzheimer'sNCT04246437[18F]F-DOPA Imaging in Patients With Autonomic Failure
This trial uses a special PET scan tracer called F-DOPA to measure dopamine production in the brain. It is studying people with autonomic nervous system…
- DLB trial, collects APOE4 dataNCT04588285Ambroxol in New and Early DLB, A Phase IIa Multicentre Randomized Controlled Double Blind Clinical Trial
This trial is testing whether ambroxol, a drug that boosts an enzyme called GCase, can slow cognitive decline, functional loss, and behavioral symptoms in…
- Open to carriers, not 4-specificNCT04715399UPenn Observational Research Repository on Neurodegenerative Disease
This is an observational study at the University of Pennsylvania — no drug or treatment involved. Researchers are building a long-term data repository by…
- Not Alzheimer-focused, genotype irrelevantNCT04997642Parkinson's Disease and Movement Disorders Clinical Database
This is not a treatment trial. It is a research database at the University of Pennsylvania that collects long-term clinical information, biological samples,…
- LBD trial, genotype not relevantNCT05014971Telehealth in Lewy Body Dementia
This trial tests whether telehealth video visits can improve access to specialized, team-based care for people with Lewy body dementia. Instead of traveling to…
- Observational only, genotype not consideredNCT05023564PUMCH Dementia Longitudinal Cohort Study
This is an observational cohort study based at a major Chinese hospital. Researchers are following elderly Chinese patients who already have a confirmed…
- Genotype irrelevant, not APOE4-specificNCT05222386Community Outreach for Palliative Engagement -- Parkinson Disease
This trial tests whether training community doctors in palliative care, combined with telemedicine support, improves quality of life for people with…
- Open to carriers, not 4-specificNCT05460143Optical Neuroimaging and Cognition
This study is testing whether near-infrared spectroscopy, a light-based brain scan, can detect changes in brain oxygen use and metabolism in people with…
- Open to carriers, not 4-specificNCT05479552A Diagnostic Test for Dementia With Lewy Bodies
This study is testing a diagnostic tool called the Syn-One Test, which looks for a protein called alpha-synuclein in a skin biopsy. The goal is to better…
- Diagnostic tool study, genotype irrelevantNCT05558709Social-cognitive Functioning: Validation of a New Neuropsychological Test
This trial is validating a new neuropsychological test called REALSoCog, a serious video game designed to detect social behavior problems in people with…
- Open to carriers, not 4-specificNCT05596760Promoting Goals-of-Care Discussions for Patients With Memory Problems and Their Caregivers
This trial tests a one-page tool called the Jumpstart Guide, given to doctors before a clinic visit, to see if it helps them have better conversations with…
- Caregiver support, genotype irrelevantNCT05779839A Study of Caregiver Connections Via Technology in Dementia
This trial is testing whether a technology-based matching program can connect dementia caregivers with peer support partners more effectively than random…
- Observational only, genotype not requiredNCT05826457North American Prodromal Synucleinopathy Consortium Stage 2
This study is building a research foundation — enrolling people with REM sleep behavior disorder (RBD) and healthy controls to prepare for future trials of…
- Lewy body trial, not APOE4 relevantNCT05847985Language and Lewy Body Diseases: Sentence Comprehension Problems and Modifying Noninvasive Brain Stimulation Treatment
This trial is testing whether a mild electrical brain stimulation technique called tDCS can help people with Lewy body diseases, specifically Parkinson's…
- Survey only, genotype not consideredNCT06005935Environmental and Reproductive Health Risk for Lewy Body Dementia
This survey study is collecting information about environmental exposures, work history, and reproductive health to understand what factors might contribute to…
- Observational only, genotype not specifiedNCT06120361The Swedish BioFINDER - Primary Care Study
This Swedish study is testing whether blood-based biomarkers and cognitive assessments can accurately detect Alzheimer's disease and other forms of cognitive…
- Observational study, genotype not specifiedNCT06122415The Swedish BioFINDER - Memory Clinic Study
This Swedish study is testing whether new blood tests can replace spinal fluid tests for diagnosing memory and dementia conditions. Researchers are comparing…
- Open to carriers, genotype-relevant donationNCT06203106NYSCF Scientific Discovery Biobank
This is a biobank study, not a treatment trial. NYSCF is collecting blood, skin, or saliva samples from people with various diseases — including Alzheimer's —…
- Records study, no APOE4 relevanceNCT06209515Sociodemographic Factors and Criminal Behaviour Preceding Neurodegenerative Disease - Retrospective Register Study
This is not a clinical treatment trial. It is a Finnish records-based research study examining whether people later diagnosed with a neurodegenerative disease…
- Observational only, genotype not relevantNCT06337578Advances in Telephone-based Cognitive Screening Procedures
This Italian observational study is testing whether cognitive screening done by telephone works as well as standard in-person testing for people with…
- Observational only, genotype not trackedNCT06357195DIAMOND-Lewy Guidelines for Antipsychotic Use in Older Patients
This observational study is tracking how often older adults in emergency departments receive antipsychotics or benzodiazepines, and whether having standardized…
- Lifestyle study, genotype not requiredNCT06378372How Does Pianistic Musical Training Influence the Development of Alzheimer's Disease?
This trial is testing whether learning to play the piano can influence how Alzheimer's disease progresses. Participants with early to moderate cognitive…
- Not relevant to APOE4 carriersNCT06389032PERSEVERE: Peer Mentor Support and Caregiver Education in Lewy Body Dementia
This trial is testing a peer mentorship program for family caregivers of people with Lewy Body Dementia. Trained caregivers who have been through LBD…
- Observational study, genotype not relevantNCT064674615-HT RBD REM Sleep Behavior Disorder
This study is investigating whether a specific type of REM sleep behavior disorder — triggered by SSRI antidepressants rather than arising on its own — might…
- Open to carriers, not 4-specificNCT06596746Neurodegenerative Diseases Progression Markers (MARKERS-NDD)
MARKERS-NDD is an observational study — no drug or treatment involved. Researchers are collecting clinical data, brain scans, blood tests, movement…
- Open to carriers, not 4-specificNCT06607900hUC-MSC-sEV-001 Nasal Drops for Neurodegenerative Diseases
This Phase 1 trial is testing nasal drops made from tiny particles released by human umbilical cord stem cells. Researchers want to know if the drops are safe…
- Observational only, genotype not a factorNCT06629207Artificial Intelligence in Molecular Imaging: Predicting Parkinson's Risk in REM Sleep Behavior Disorder
This study is tracking people who have REM sleep behavior disorder — a condition where people act out their dreams — to see if brain scans analyzed by AI can…
- Existing dementia only, genotype irrelevantNCT06631742Exergaming Revolution in Dementia
This pilot trial is testing whether 12 weeks of exergaming — playing video games that require physical movement, using a platform called the Dividat Senso —…
- Non-drug trial, genotype not consideredNCT06733714Association of Transcranial Alternating Current Stimulation with Digital Cognitive Training for Cognitive Remediation in Older Adults
This trial combines two non-drug approaches — a brain-stimulation device called tACS, which delivers mild electrical currents to the scalp, and a computerized…
- Open to carriers, not 4-specificNCT06862557Pulsed Electromagnetic Field Treatment With Dementia Patients
This trial is testing a wearable device that emits pulsed electromagnetic fields, used at home three times a day for 120 days, in people with mild to moderate…
- Unrelated to APOE4 or Alzheimer'sNCT06949865AI-Enhanced Optimization of Acute Levodopa Challenge Test
This trial is testing whether AI and video analysis can improve how doctors diagnose different types of Parkinson's-related conditions. Patients take a…
- Open to carriers, not 4-specificNCT06978946Deep Cervical Lymphaticovenous Anastomosis Surgery for Moderate-to-Advanced Dementia Patients
This trial is testing a surgical procedure called Deep Cervical Lymphaticovenous Anastomosis, or DLVA, in people aged 50 to 80 with moderate to severe…
- Diagnostic study, genotype not targetedNCT07166744Contribution of Pathological Alpha-synuclein as a Diagnostic Biomarker for Dementia With Lewy Bodies
This study is testing whether a specific lab measurement of abnormal alpha-synuclein protein, drawn from spinal fluid, a nasal swab, and blood, can reliably…
- Unrelated to APOE4 genotypeNCT0717628618F-mFBG Cardiac Uptake With Lewy Body Dementia
This trial is testing a radioactive imaging agent called 18F-mFBG to see how well it can detect nerve damage in the heart caused by Lewy body diseases like…
- Not Alzheimer's, APOE4 irrelevantNCT07240805Digital Health Technologies for Progressive Supranuclear Palsy and Dementia With Lewy Bodies
This study is testing wearable sensor devices to track movement and physical function in people already diagnosed with Progressive Supranuclear Palsy, MCI with…
- Open to carriers, not 4-specificNCT07545473Retinal Hyperspectral Imaging in Neurodegenerative Diseases
This study tests whether a special eye-scanning camera can detect signs of Alzheimer's and other brain diseases by photographing the retina using multiple…
- Unrelated to APOE4 or Alzheimer'sNCT07604883Early Molecular Biomarkers for Differentiating Parkinsonian Syndromes
This observational study is looking for molecular clues in blood, urine, and stool that could help doctors tell Parkinson's disease apart from rarer movement…
- Lewy body focus, genotype not specifiedNCT07629349Dementia With Lewy Bodies: Clinical Symptoms, Biomarkers and Progression
This observational study is tracking people who show early signs of dementia with Lewy bodies, such as visual hallucinations, movement changes, cognitive…
- Caregiver trial, no APOE4 relevanceNCT07637097VOCALE LBD: Online Peer Support for Caregivers of People With Lewy Body Dementia
This trial tests whether an online peer support program called VOCALE LBD helps reduce depression in family caregivers of people with Lewy Body Dementia.…
- Biobank study, not genotype specificNCT07798700Biofluid Research on Age-Related or Inherited Neurodegeneration
This isn't a treatment trial. It's a biobank collecting blood, DNA/RNA, and family history from people with neurodegenerative diseases (Alzheimer's,…
Copy a forum-ready post
Keep exploring
Educational, not medical advice. Trial decisions belong between you and your physician.