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For APOE4 carriers

Beat the odds.Defeat Alzheimer's.

Bloodwork tuned to your genes. A community of carriers like you. Protocols validated by APOE4 research. Access to APOE4 studies and clinical trials. Group savings on the supplements that matter.

89% improve APOE4 biomarkers in 3mo60-day money-back guarantee
Dr. Kevin Tran, Doctor of Pharmacy, APOE 4/4 carrier, founder of PhoenixBuilt by Dr. Kevin Tran, Doctor of Pharmacy, APOE 4/4
I · Community · Pod 047 · 92% match

Four carriers. Real progress.

7 days to match
Year 10
Cognition intact
Donna D.
APOE 4/4 · 72
5.4A1C
Down from 5.7
Deb B.
APOE 4/4 · Coach
0.09pTau
Half of borderline
John Y.
APOE 3/4 · MO
7Hcy
Down from 13
Gertrude B.
APOE 4 · AU
✧ Matched on genotype · goals · stage · time zoneNext match · 1 Jun

Phoenix tracks 27 APOE4-critical biomarkers against APOE4-optimal ranges. 603+ members are already working their protocol.

Active members
603+
4 new APOE4 carriers join us every day
Improvements in APOE4 biomarkers
89%
in 3 months · self-reported
Member rating
4.9/5
32% are healthcare professionals
60-day retention
94%
Members stay because it works
As seen in
The signal problem

You can't afford to guess.

There is no shortage of advice for APOE4. There is a shortage of advice that works for your genotype. Phoenix is the difference.

The signal

Tuned to your genotype, validated by your bloodwork, run by 603+ carriers.

27APOE4-optimized biomarkers
2.6×Greater cognitive benefitFINGER trial · carriers vs non-carriers (Ngandu 2015)
89%Members improved a critical biomarkerwithin 3 months
One year from now

One plan. Yours.

Here’s what life feels like when the overwhelm gets quiet.

And you feel calmer.
Not pulled in ten directions.

  1. 01You start with one clear path.
  2. 02Each day, Phoenix AI helps show what to keep, change, or drop.
  3. 03You keep what fits your life.
  4. 04You have people who truly understand.
  5. 05You hear about studies you may qualify for.
  6. 06You get a short list of supplements worth trying.
What you'll track

27 critical biomarkers, read against APOE4-optimal ranges.

Not the generic lab “normal.” The optimal window for a 4/4 carrier, so you see what is actually working before it shows up as symptoms.

Biomarker
Standard
APOE4 optimal
Why it matters
01 / LIPIDS
ApoB
mg/dL
< 90
40–60
APOE4 carriers metabolize lipids differently. <130 is dangerously permissive.
● Each 10 mg/dL drop = 9% lower CV risk
Belloy ME et al. Neuron. 2019;101(5):820–838
02 / NEURO
pTau-217
pg/mL
not run
< 0.18
Detects Alzheimer's pathology 20 years before symptoms.
● 93–96% accuracy decades before symptoms
Mattsson-Carlgren N et al. EMBO Mol Med. 2021;13(12):e14619
03 / LIPIDS
Omega-3 Index
%
> 4
> 8
APOE4 brains are starved for DHA. Doubling intake is non-optional.
● ≥8% linked to 69% lower cardiac risk + larger brain volume
Yassine HN et al. Alzheimers Dement. 2020;16(12):1674–1685
04 / METABOLIC
HbA1c
%
< 5.7
4.5–5.2
APOE4 brains run insulin-resistant even at 'normal' A1C. The link to amyloid is direct.
● Each 1% above optimal = 20–30% higher cardiovascular mortality
Crane PK et al. N Engl J Med. 2013;369(6):540–548
05 / INFLAMMATION
hs-CRP
mg/L
< 3.0
< 1.0
APOE4 brains run hot. Chronic inflammation × APOE4 = accelerated amyloid deposition.
● Hypertension + APOE4 + inflammation = synergistic risk
Tao Q et al. Neurology. 2018;91(5):e483–e492
06 / METHYLATION
Homocysteine
µmol/L
< 15
< 9
Methylation matters more for APOE4. Standard ranges miss it.
● B-vitamin protocol → 53% less brain atrophy in MCI
Smith AD et al. PLoS One. 2010;5(9):e12244
+ 21 more biomarkers in the Core dashboard · every range backed by peer-reviewed citation
See the science behind the framework
The math of APOE4

Your risk isn't fixed.
It's a number you can move.

An APOE 4/4 genotype can push lifetime Alzheimer's risk toward 60 percent. But multidomain prevention trials show APOE4 carriers respond especially strongly, so the right actions, started early, can move that number substantially.

● Lifetime Alzheimer's risk by age 85Scale: 0–100% lifetime risk
~60%
APOE 4/4 untreated
Measured lifetime risk · Genin 2011
~22%
APOE 4/4 optimized
Modeled · FINGER-style intervention
About 63% lower risk in the optimized scenario (from ~60% to ~22%)
Genin E et al., Mol Psychiatry 2011Ngandu T et al., Lancet 2015 (FINGER)Fortea J et al., Nat Med 2024
2.6×
FINGER trial · APOE4 carriers

APOE4 carriers showed 2.6× greater cognitive benefit from multidomain intervention (diet + exercise + cognitive training + vascular management) than non-carriers. The earlier you start, the bigger the gap.

Start moving your number →7 minutes · 60-day guarantee
✧ Accountability pods

Get matched with carriers
who actually get it.

Each month, Phoenix matches you into a private pod of 2–4 APOE4 carriers working the same goal you are. Real people, real accountability. So you never optimize alone.

Next match opens 1 Jun · 7 days to set your goal
Your pod · September
Lipid control — lowering ApoB
Illustrative
YouYou
EllenEllen
JohnJohn
DonnaDonna
Ellen
Ellen7:14 a.m.
ApoB came back 89 this month, down from 134 in March. It wasn't one supplement. It was finally staying consistent because you all check in on me.
John
John9:02 a.m.
That's the push I needed. Booked my first CAC scan for Oct 4. I'd have put it off again on my own.
104 other pods this monthLipidsCognitionSleepZone 2MetabolicHormones+97 more
3.2xmore consistent
94%active at 60 days
+21%wellbeing vs solo
Member outcomes

Real members. Real outcomes.

Bloodwork moved. Brain fog cleared. A decade lived clear-headed at 4/4. The numbers our members are actually changing, verified by labs, validated by life.

Read all member stories
Portrait of Dr. John Yoder
Dr. John Yoder, 68
Retired Physician · Missouri
3/4
0.09
p-tau · half of borderline
● Verified by labs

“I would have never heard of P-tau testing without this group. Even if none of this prevents Alzheimer’s, I’m living these years healthy and energetic.”

Portrait of Robin P. Shwetzer
Robin P. Shwetzer, 62
NBC-HWC Coach · Florida
3/4
5.7 → 5.4
A1C · brain fog gone
● Verified by labs

“A1C 5.7 to 5.4 on keto-flex, brain fog gone in about a month. Homocysteine 13 to 7 with methylated B vitamins.”

Portrait of Donna Dorans
Donna Dorans, 72
Year 10 since diagnosis
4/4
Intact
Cognition · decade with 4/4
● Verified by family

“It’s like I found my people. The Phoenix app is building something personal that works for me, not a one-size-fits-all protocol.”

Three of dozens · full interviews, deltas, and screenshots on the stories page
Browse every story
The counterfactual

Same genes. Different destinies.

Two women. Same APOE 4/4 diagnosis, the highest known genetic risk for Alzheimer's. Both fought back in their early 50s. Both gave it everything. Twenty years later, only one still recognized her grandchildren.

She didn't try harder. So what did she know?

Start measuring

5 minutes · 60-day money-back

Dr. Kevin Tran, Doctor of Pharmacy, APOE 4/4 carrier, founder of Phoenix
Founder · Member 001
Dr. Kevin Tran
DOCTOR OF PHARMACY · APOE 4/4
Who am I?

I carry the same genotype you do.

I'm a Doctor of Pharmacy, and I spent a decade studying the very gene I turned out to carry, two copies of it. When the result came back, my doctor told me the same thing yours probably did, come back at sixty. I refused to wait. So I read 800 papers, consulted 40 researchers, and built the protocol I needed, the one I now run on my own bloodwork and share with hundreds of carriers.

  • Doctor of Pharmacy, clinical residency in geriatric care
  • I carry APOE 4/4, the same as you
  • I advised Biogen on Alzheimer's strategy
  • I wrote Phoenix's 27-biomarker APOE4 framework

“I built Phoenix because I needed it. Now we build it together.”

Dr. Kevin Tran, APOE 4/4
Clinical trials engine

Every APOE4 trial,
filtered to you, daily.

Phoenix scans ClinicalTrials.gov nightly and surfaces the ones you might qualify for , by genotype, geography, biomarker profile. One-tap interest gets you a warm intro from our research team.

Today · 3 new matches
Sarah K. · 4/4 · CA
Lecanemab early-access · APOE 4/4 cohort
● UCSF
92%
match
Lifestyle-Rx trial · APOE4 + insulin resistance
● Mass General
88%
match
GLP-1 + cognition · APOE4 women 50–65
● Stanford
84%
match
Updated nightly · 1,200+ trials scanned
Full transparency

What it would cost to build this yourself.

The honest math. What you'd pay to put this together on your own, month after month, and what you pay instead.

Standalone alternativeper month
Biomarker tracking + blood analysis
From Alzheimer’s & APOE4 experts
$200
Covered
Phoenix AI, personalized to your APOE4
Better than a functional-medicine consult
$1,500
Covered
Accountability pod, 4-person matched
Group-coaching equivalent
$100
Covered
APOE4 community + expert Q&As
Vetted private network
$80
Covered
APOE4 studies, subsidies & group discounts
Collective negotiating power
$250
Covered
Total if sourced separately
$2,130/mo
With Phoenix Core
You save $2,061 every month
$69/mo
Start with Core →Compare every tier7 min · 60-day guarantee
Honest answers

Questions members ask first.

Q.01I just found out. Is it too late?

It is not. APOE4 raises lifetime Alzheimer's risk roughly 4–5× above baseline, but it does not seal fate. The members with the largest biomarker swings are the ones who started in their fifties and sixties, every year of intervention bends the curve.

Q.02I am joining for a parent, partner, or someone I love.

You belong here too. About one in three of our members is a caregiver or family member supporting an APOE4 carrier, you get the same tools, pod, and Dr. Tran access, and you'll find people who have walked exactly your road.

Q.03I am not a biohacker.

Neither are most members, average is a 55-year-old woman. The app walks you through every step, your pod keeps you honest, and Dr. Tran is one message away.

Q.04I am 3/4, not 4/4. Does this apply?

Yes. Phoenix is built for any APOE4 carrier. The urgency dial is lower, the playbook is the same.

Q.05Can I cancel?

Yes, any time, one click, no questions. 60-day full money-back guarantee on your first quarter.

Start now

Don't wait for symptoms.
Start today.

Every month without tracking is a month of data you can't get back. Join 603+ APOE4 carriers already tracking 27 APOE4-critical biomarkers against APOE4-optimal ranges.

Next pod matching opens 1 Jun · join in the next 7 days
7 minutes60-day guarantee

“I built Phoenix because I needed it. Now we build it together.”

Dr. Kevin Tran, APOE 4/4
The Phoenix app, iOS & Android

Phoenix provides health optimization guidance and community support. It is not a medical treatment, diagnosis tool, or substitute for professional medical advice. Consult your physician before starting any new health program.

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