Understanding Brain Inflammation in Cognitive Problems (BRIC)

Eligibility criteria

Inclusion Criteria:
MCI-LB/DLB group:
1. Age ≥60 years
2. Fulfil criteria for probable MCI-LB (McKeith et al., 2020) or DLB (McKeith et al., 2017)
3. Capacity to consent to participation in the study
4. MMSE ≥20
5. If on cholinesterase inhibitors and/or memantine, stable dose for 3 months
Control group:
1. Age ≥60 years
2. MMSE ≥27
3. No evidence of mild cognitive impairment or dementia
Exclusion Criteria:
1. Active systemic inflammatory disease
2. Active autoimmune disease
3. Taking immune system modifying medications (e.g., oral steroids or tumour necrosis factor inhibitors)
4. Taking incretin analogues (e.g., liraglutide), minocycline or other microglial suppressing agents
5. History of clinical stroke
6. Current major depression
7. History of bipolar disorder, non-organic psychosis (e.g., longstanding schizophrenia) or recurrent severe depression
8. Chronic migraine

The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.

Eligibility criteria as of 2025-05-19