NCT05768425 · ACTIVE NOT RECRUITING
DIagnostic Biomarkers and Symptoms in Patients With Alzheimer's Disease and Lewy bodY Dementia
This study tests whether a lab method called RT-QuIC can help doctors diagnose dementia with Lewy bodies more accurately. It checks the test in different body samples and compares people with Lewy body dementia, people with Alzheimer's, and healthy young adults. Cognitive and movement exams are included. No drug is given, and no phase is listed.
Eligibility criteria
Inclusion criteria for healthy controls (HC): * Age 18 - 40 years of age * Able to cooperate as evaluated by the primary investigator (PI) * Able to give informed consent Exclusion criteria * Signs of neurological/psychiatric conditions * Known genetic neurodegenerative disease in close family Inclusion criteria for patients with Dementia with Lewy Bodies (DLB): * Probable DLB (McKeith et al., 2017) or MCI-LB (McKeith et al., 2020) * Age > 50 years of age * Able to give informed consent * Able to cooperate as evaluated by the PI * MCI, mild or moderate dementia, and MMSE > 18 Exclusion criteria for patients with DLB: * Patients not able to give informed consent. * Current alcohol or drug abuse * Terminal illness * Diagnosed with major neurological/psychiatric conditions other than DLB. Inclusion criteria for controls (patients with Alzheimer's disease (AD)): * Probable AD (McKhann et al., 2011) or MCI-AD (Albert et al., 2011) * Age > 50 years of age * Able to give informed consent * Able to cooperate as evaluated by the PI * MCI, mild or moderate dementia, and MMSE > 18 Exclusion criteria for controls (patients with AD): * Patients not able to give consent. * Current alcohol or drug abuse * Terminal illness * Diagnosed with major neurological/psychiatric conditions other than AD.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2023-10-10