NCT02434393 · RECRUITING
Characterizing Cognitive Decline in Late Life Depression: The ADNI Depression Project
This observational study follows older adults with late life depression to understand why some develop memory and thinking problems faster. Participants get brain MRI, amyloid and tau PET scans, blood tests, and cognitive testing. Nobody receives a treatment. It has no formal phase because it measures and observes rather than tests an intervention.
Eligibility criteria
Inclusion Criteria: 1. Individual participated in original Characterizing Cognitive Decline in Late Life Depression study or Multimodal MRI Characteristics of Psychotherapy Response in Late Life Depression Study. Exclusion Exceptions: 1. Antidepressant medication treatment is allowed only if the medication dose is stable for 4 weeks prior to the MRI scan. 2. Psychotherapy interventions is allowed only if they have completed at least 4 weeks of individual or group psychotherapy intervention prior to the MRI scan. 3. Participants taking cognitive enhancing medications will be able to enter the study.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-11-25