Frontotemporal dementia trials.
102 Frontotemporal dementia trials, curated for APOE4 carriers — 69 of them recruiting. Each one translated into plain English, with our read on what it means for an APOE4 carrier.
- Carriers specifically sought, non-drug deviceNCT07222605Research Study for Patients With Neurological Diseases Which Evaluates the Patient Experience of the MemorEM Device
This pilot study tests a wearable head device called MemorEM in people with neurological diseases including Alzheimer's, Parkinson's, and frontotemporal…
- Aphasia diagnosis required, not APOE4-specificNCT00537004Language in Primary Progressive Aphasia
This study looks at how language and brain function change over time in people with primary progressive aphasia, a condition that gradually affects speech and…
- Not APOE4-related; rare VCP gene studyNCT01353430Characterization of Inclusion Body Myopathy Associated With Paget's Disease of Bone and Frontotemporal Dementia (IBMPFD)
This is a research study, not a drug trial. Investigators are collecting blood, urine, family histories and questionnaires from families with a rare inherited…
- Rare disease registry, not APOE4-relevantNCT01793168Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
This is not a drug or treatment trial. It is a free patient registry run by Sanford Research in South Dakota. People with a rare disease, an undiagnosed…
- Speech disorder imaging study, not APOE4-specificNCT01818661Longitudinal Multi-Modality Imaging in Progressive Apraxia of Speech
This study uses brain scans, including a PET scan with a tracer drug called AV-1451 that highlights tau protein, to follow people with progressive apraxia of…
- Observational family study, not APOE4-specificNCT02055092Young Onset Dementia - the Difficult Diagnosis and the Stressful Life for the Whole Family
This is an observational study, not a drug test. Researchers are looking at how young onset dementia, meaning symptoms starting before age 65, affects quality…
- Not Alzheimer's-focused, not APOE4-specificNCT02327845Phenotype, Genotype & Biomarkers in ALS and Related Disorders
This is an observational study, so nothing is being tested as a treatment. Researchers are looking at how the genes and symptoms of ALS and related conditions,…
- Not APOE4-specific; for existing neurologic damageNCT02795052Neurologic Stem Cell Treatment Study
This study takes a person's own bone marrow stem cells and delivers them through a vein and the lower nose. Researchers want to see whether neurologic function…
- FTD imaging study, not APOE4-focusedNCT02945774Molecular Neuroimaging of Neuroinflammation in Neurodegenerative Dementias
This study uses a brain scan (PET/MRI) with a tracer called FEPPA to look for inflammation in the brains of people with frontotemporal dementia, and to see how…
- Not Alzheimer's-focused, APOE4 not addressedNCT02964637Diagnosing Frontotemporal Lobar Degeneration
This is an observational study, meaning no drug or treatment is given. Researchers are working to build better diagnostic tools, such as brain imaging and…
- Observational study, not APOE4-specificNCT03174938The Swedish BioFINDER 2 Study
BioFINDER 2 is an observational study in Sweden. It uses brain scans (amyloid and tau PET), spinal fluid tests, and MRI to track how Alzheimer's and related…
- Unrelated conditions, not APOE4-relevantNCT03225144Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
This is a screening and natural history study at the NIH, not a treatment trial. Researchers are enrolling people already diagnosed with ALS, frontotemporal…
- Explicitly lists APOE4-positive carriersNCT03233646Retinal Imaging in Neurodegenerative Disease
This study uses non-invasive eye-imaging technology — optical coherence tomography (OCT) and wide-field retinal photography — to look for early signs of…
- Not relevant; Alzheimer's patients excludedNCT03313011The Neurobiology of Two Distinct Types of Progressive Apraxia of Speech
This study uses brain imaging and clinical testing to tell apart two types of progressive apraxia of speech, a rare condition where speech slowly becomes…
- Observational study, genotype not specifiedNCT03402919Comprehensive Assessment of Neurodegeneration and Dementia
This is an observational study, meaning no drug or treatment is being tested. Researchers across Canada will follow people aged 50 to 90 over time, including…
- Not relevant: ALS records study, no APOE4NCT03489278Clinical Procedures to Support Research in ALS
This study uses information already in the medical records of people with ALS and related conditions to learn more about those diseases. It tests no drug or…
- Diagnosis-specific, genotype not a factorNCT03887481Targeting Language-specific and Executive-control Networks With Transcranial Direct Current Stimulation in Logopenic Variant PPA
This trial tests whether brain stimulation using a weak electrical current (called tDCS) delivered to specific language and memory areas of the brain, combined…
- Not Alzheimer's-focused, not APOE4-specificNCT03912987TRIAL READY (Clinical Trial Readiness)
This is an observational study, not a drug test. It collects biological fluid samples, such as blood, from people with ALS and related conditions, plus healthy…
- Monitoring tool, genotype not relevantNCT04114994Longitudinal Cognitive Assessment by BoCA
This study is testing a self-administered online cognitive test called BoCA — the Boston Cognitive Assessment. Researchers want to see how well it tracks…
- Unrelated to APOE4 genotypeNCT04220021Safety and Therapeutic Potential of the FDA-approved Drug Metformin for C9orf72 ALS/FTD
This trial is testing whether metformin, a widely used diabetes drug, is safe for people with a specific genetic form of ALS and frontotemporal dementia caused…
- FTLD-focused, not APOE4-relevantNCT04363684ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)
This is a large North American research registry and natural history study tracking people with frontotemporal lobar degeneration (FTLD) and related conditions…
- Wrong condition, not APOE4-relevantNCT04408625Phase 1/2 Clinical Trial of LY3884963 in Patients With Frontotemporal Dementia With Progranulin Mutations (FTD-GRN)
This trial is testing LY3884963, a biological therapy delivered directly into the fluid around the brain and spine, in people who have frontotemporal dementia…
- Not APOE4-related; FTD gene families onlyNCT04516499Neurofilament Surveillance Project (NSP)
This is a blood-collection study, not a drug test. Researchers are measuring neurofilament, a protein that can signal nerve cell damage, in people from…
- FTD genetics only, not APOE4NCT04639622GENetic Fronto Temporal Dementia Initiative in Lille
This trial is tracking people from families with a known genetic mutation linked to frontotemporal dementia (FTD) — specifically mutations in GRN, MAPT, or…
- Open to carriers, not 4-specificNCT04715399UPenn Observational Research Repository on Neurodegenerative Disease
This is an observational study at the University of Pennsylvania — no drug or treatment involved. Researchers are building a long-term data repository by…
- Not for APOE4; FTD gene mutations onlyNCT04747431A Study of PBFT02 in Participants With FTD and Mutations in the Granulin Precursor (GRN) or C9ORF72 Genes
PBFT02 is a gene therapy meant to deliver a working copy of the GRN gene to the brain. This trial looks at its safety, how well people tolerate it, and early…
- Diagnosis study, not APOE4-specificNCT04844060Cerebro Spinal Fluid Collection (CSF)
This study collects cerebrospinal fluid, the fluid around the brain and spine, through a lumbar puncture (spinal tap). Researchers want to see whether…
- Not Alzheimer's-focused, APOE4 not mentionedNCT04875416Phenotype, Genotype and Biomarkers 2
This is an observational study, meaning no drug or treatment is given. Researchers are looking at people with ALS and related conditions, including…
- Not relevant to APOE4 riskNCT04881617Treatment for Speech and Language in Primary Progressive Aphasia
This trial is testing two speech-language therapies for people with primary progressive aphasia, a neurological condition that slowly erodes the ability to…
- Not relevant to most carriersNCT04920318Enhancing Language Function in Primary Progressive Aphasia
This trial is testing whether pairing a mild electrical brain stimulation technique called tDCS with standard language therapy works better than language…
- Diagnostic study, genotype not relevantNCT04946916Neurofilament Light Chains and Cognitive Impairment in Chronic Psychiatric Disease
This study is testing whether a simple blood test measuring a protein called neurofilament light chain (NfL) can help doctors tell apart cognitive decline…
- Unrelated condition, not APOE4-relevantNCT04957537Semantic Rehabilitation for Patients With Primary Progressive Semantic Aphasia
This trial is testing a behavioral therapy program designed to help people with semantic primary progressive aphasia — a rare condition that gradually erodes…
- Not APOE4-related; FTD-GRN drug trialNCT05262023A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DNL593 in Healthy Participants and Participants With Frontotemporal Dementia (FTD-GRN)
This study is testing DNL593, an experimental drug, against a placebo. It looks at safety, how the body processes the drug, and its effects on the body. It…
- Observational study, not APOE4-specificNCT05288842Tanycytes in Alzheimer's Disease and Frontotemporal Dementia
This is an observational study, not a treatment trial. Researchers take blood and spinal fluid (lumbar puncture) from healthy adults and people with…
- Wrong disease, not APOE4-relevantNCT05315661The Safety and The Efficacy Evaluation of ET-STEM in Patients With Frontotemporal Dementia
This Phase 1 trial is testing whether ET-STEM — mesenchymal stem cells treated with the drug ethionamide — is safe and tolerable when given in three repeated…
- Device study, symptomatic patients, not 4-specificNCT05326750Non-invasive Neurostimulation as a Tool for Diagnostics and Management for Neurodegenerative Diseases
This trial tests whether a gentle, non-invasive brain stimulation device, applied to the scalp over the back of the brain at 40 Hz, can improve symptoms in…
- Not Alzheimer-focused, genotype irrelevantNCT05368350Treating Primary Progressive Aphasia and Apraxia of Speech Using Non-invasive Brain Stimulation
This trial is testing whether a gentle electrical current applied to specific brain regions can improve speech and language problems in people with primary…
- Imaging study, genotype not a factorNCT05374278First-in-Human Evaluation of an Astrocytic Glutamate Transporter (EAAT2) PET Tracer in Dementia
This trial is testing a new PET scan tracer called [18F]RP-115, which is designed to image a protein called EAAT2 — a glutamate transporter found on brain…
- Not APOE4-related, PPA patients onlyNCT05386394Transcranial Direct Current Stimulation in the Treatment of Primary Progressive Aphasia
This trial is testing whether transcranial direct current stimulation (tDCS) — a mild electrical current applied to the scalp — combined with language therapy…
- Not relevant to APOE4 carriersNCT05443633Enhancing Language Function in Aphasia
This trial is testing whether individualized speech-language training works better than standard language therapy for people with aphasia — a language…
- Imaging study, not APOE4-specificNCT05456503PET Imaging Tau Accumulation in FTLD and Atypical Alzheimer's Using [18F]-PI-2620
This study uses a brain scan with a tracer called PI-2620 to look at tau, a protein that builds up in some brain diseases. Researchers will compare scans from…
- Diagnostic tool study, genotype irrelevantNCT05558709Social-cognitive Functioning: Validation of a New Neuropsychological Test
This trial is validating a new neuropsychological test called REALSoCog, a serious video game designed to detect social behavior problems in people with…
- Open to carriers, not 4-specificNCT05596760Promoting Goals-of-Care Discussions for Patients With Memory Problems and Their Caregivers
This trial tests a one-page tool called the Jumpstart Guide, given to doctors before a clinic visit, to see if it helps them have better conversations with…
- Not relevant to APOE4 carriersNCT05741853Cognitive Reserve and Response to Speech-Language Intervention in Bilingual Speakers With Primary Progressive Aphasia
This trial is testing two speech-language therapy approaches — script training and word-finding practice — in bilingual people who have primary progressive…
- Not APOE4-related; youth FTD family studyNCT05779813Genetic Frontotemporal Dementia Initiative for Neurodevelopment
This is an observational study, not a drug test. It follows children and teens ages 9 to 16 who have a parent or grandparent with a genetic form of…
- Caregiver support, genotype irrelevantNCT05779839A Study of Caregiver Connections Via Technology in Dementia
This trial is testing whether a technology-based matching program can connect dementia caregivers with peer support partners more effectively than random…
- Genetic study, not APOE4-specificNCT05911932Investigating Genetic Status in Patients Presenting to Clinic
This is a genetic research study, not a treatment trial. Researchers at a memory clinic will collect blood samples from people with suspected or confirmed…
- Unrelated to APOE4 or Alzheimer'sNCT05956834A Multi-Modal Remote Monitoring Platform for Frontotemporal Lobar Degeneration (FTLD) Syndromes
This observational study is tracking motor symptoms in people diagnosed with Progressive Supranuclear Palsy (PSP) using two wearable sensor devices — PAMSys…
- Observational study, genotype not relevantNCT06059313Premorbid Personality Profile of Patients With Cognitive and Behavioral Disorders
This study is looking at whether a person's personality before they got sick might help explain why some people develop behavioral and cognitive symptoms from…
- Not applicable to APOE4 carriersNCT06064890A Study to Evaluate the Safety and Effect of AVB-101, a Gene Therapy Product, in Subjects With a Genetic Sub-type of Frontotemporal Dementia (FTD-GRN)
This Phase 1 trial is testing AVB-101, a gene therapy delivered directly into the brain through a surgical procedure. It targets a specific inherited form of…
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Educational, not medical advice. Trial decisions belong between you and your physician.