Frontotemporal dementia trials.
60 Frontotemporal dementia trials, curated for APOE4 carriers — 40 of them recruiting. Each one translated into plain English, with our read on what it means for an APOE4 carrier.
- Carriers specifically sought, non-drug deviceNCT07222605Research Study for Patients With Neurological Diseases Which Evaluates the Patient Experience of the MemorEM Device
This pilot study tests a wearable head device called MemorEM in people with neurological diseases including Alzheimer's, Parkinson's, and frontotemporal…
- Unrelated conditions, not APOE4-relevantNCT03225144Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
This is a screening and natural history study at the NIH, not a treatment trial. Researchers are enrolling people already diagnosed with ALS, frontotemporal…
- Explicitly lists APOE4-positive carriersNCT03233646Retinal Imaging in Neurodegenerative Disease
This study uses non-invasive eye-imaging technology — optical coherence tomography (OCT) and wide-field retinal photography — to look for early signs of…
- Diagnosis-specific, genotype not a factorNCT03887481Targeting Language-specific and Executive-control Networks With Transcranial Direct Current Stimulation in Logopenic Variant PPA
This trial tests whether brain stimulation using a weak electrical current (called tDCS) delivered to specific language and memory areas of the brain, combined…
- Monitoring tool, genotype not relevantNCT04114994Longitudinal Cognitive Assessment by BoCA
This study is testing a self-administered online cognitive test called BoCA — the Boston Cognitive Assessment. Researchers want to see how well it tracks…
- Unrelated to APOE4 genotypeNCT04220021Safety and Therapeutic Potential of the FDA-approved Drug Metformin for C9orf72 ALS/FTD
This trial is testing whether metformin, a widely used diabetes drug, is safe for people with a specific genetic form of ALS and frontotemporal dementia caused…
- FTLD-focused, not APOE4-relevantNCT04363684ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)
This is a large North American research registry and natural history study tracking people with frontotemporal lobar degeneration (FTLD) and related conditions…
- Wrong condition, not APOE4-relevantNCT04408625Phase 1/2 Clinical Trial of LY3884963 in Patients With Frontotemporal Dementia With Progranulin Mutations (FTD-GRN)
This trial is testing LY3884963, a biological therapy delivered directly into the fluid around the brain and spine, in people who have frontotemporal dementia…
- FTD genetics only, not APOE4NCT04639622GENetic Fronto Temporal Dementia Initiative in Lille
This trial is tracking people from families with a known genetic mutation linked to frontotemporal dementia (FTD) — specifically mutations in GRN, MAPT, or…
- Open to carriers, not 4-specificNCT04715399UPenn Observational Research Repository on Neurodegenerative Disease
This is an observational study at the University of Pennsylvania — no drug or treatment involved. Researchers are building a long-term data repository by…
- Not relevant to APOE4 riskNCT04881617Treatment for Speech and Language in Primary Progressive Aphasia
This trial is testing two speech-language therapies for people with primary progressive aphasia, a neurological condition that slowly erodes the ability to…
- Not relevant to most carriersNCT04920318Enhancing Language Function in Primary Progressive Aphasia
This trial is testing whether pairing a mild electrical brain stimulation technique called tDCS with standard language therapy works better than language…
- Diagnostic study, genotype not relevantNCT04946916Neurofilament Light Chains and Cognitive Impairment in Chronic Psychiatric Disease
This study is testing whether a simple blood test measuring a protein called neurofilament light chain (NfL) can help doctors tell apart cognitive decline…
- Unrelated condition, not APOE4-relevantNCT04957537Semantic Rehabilitation for Patients With Primary Progressive Semantic Aphasia
This trial is testing a behavioral therapy program designed to help people with semantic primary progressive aphasia — a rare condition that gradually erodes…
- Wrong disease, not APOE4-relevantNCT05315661The Safety and The Efficacy Evaluation of ET-STEM in Patients With Frontotemporal Dementia
This Phase 1 trial is testing whether ET-STEM — mesenchymal stem cells treated with the drug ethionamide — is safe and tolerable when given in three repeated…
- Not Alzheimer-focused, genotype irrelevantNCT05368350Treating Primary Progressive Aphasia and Apraxia of Speech Using Non-invasive Brain Stimulation
This trial is testing whether a gentle electrical current applied to specific brain regions can improve speech and language problems in people with primary…
- Imaging study, genotype not a factorNCT05374278First-in-Human Evaluation of an Astrocytic Glutamate Transporter (EAAT2) PET Tracer in Dementia
This trial is testing a new PET scan tracer called [18F]RP-115, which is designed to image a protein called EAAT2 — a glutamate transporter found on brain…
- Not APOE4-related, PPA patients onlyNCT05386394Transcranial Direct Current Stimulation in the Treatment of Primary Progressive Aphasia
This trial is testing whether transcranial direct current stimulation (tDCS) — a mild electrical current applied to the scalp — combined with language therapy…
- Not relevant to APOE4 carriersNCT05443633Enhancing Language Function in Aphasia
This trial is testing whether individualized speech-language training works better than standard language therapy for people with aphasia — a language…
- Diagnostic tool study, genotype irrelevantNCT05558709Social-cognitive Functioning: Validation of a New Neuropsychological Test
This trial is validating a new neuropsychological test called REALSoCog, a serious video game designed to detect social behavior problems in people with…
- Open to carriers, not 4-specificNCT05596760Promoting Goals-of-Care Discussions for Patients With Memory Problems and Their Caregivers
This trial tests a one-page tool called the Jumpstart Guide, given to doctors before a clinic visit, to see if it helps them have better conversations with…
- Not relevant to APOE4 carriersNCT05741853Cognitive Reserve and Response to Speech-Language Intervention in Bilingual Speakers With Primary Progressive Aphasia
This trial is testing two speech-language therapy approaches — script training and word-finding practice — in bilingual people who have primary progressive…
- Caregiver support, genotype irrelevantNCT05779839A Study of Caregiver Connections Via Technology in Dementia
This trial is testing whether a technology-based matching program can connect dementia caregivers with peer support partners more effectively than random…
- Unrelated to APOE4 or Alzheimer'sNCT05956834A Multi-Modal Remote Monitoring Platform for Frontotemporal Lobar Degeneration (FTLD) Syndromes
This observational study is tracking motor symptoms in people diagnosed with Progressive Supranuclear Palsy (PSP) using two wearable sensor devices — PAMSys…
- Observational study, genotype not relevantNCT06059313Premorbid Personality Profile of Patients With Cognitive and Behavioral Disorders
This study is looking at whether a person's personality before they got sick might help explain why some people develop behavioral and cognitive symptoms from…
- Not applicable to APOE4 carriersNCT06064890A Study to Evaluate the Safety and Effect of AVB-101, a Gene Therapy Product, in Subjects With a Genetic Sub-type of Frontotemporal Dementia (FTD-GRN)
This Phase 1 trial is testing AVB-101, a gene therapy delivered directly into the brain through a surgical procedure. It targets a specific inherited form of…
- Single-patient study, not APOE4-specificNCT06093126Lemborexant for Insomnia in a Patient With Dementia: An N-of-1 Trial
This trial tests lemborexant, a newer sleep medication, in a single patient with early-onset dementia and insomnia. Unlike older sleep drugs, it is designed to…
- Observational only, genotype not specifiedNCT06120361The Swedish BioFINDER - Primary Care Study
This Swedish study is testing whether blood-based biomarkers and cognitive assessments can accurately detect Alzheimer's disease and other forms of cognitive…
- Observational study, genotype not specifiedNCT06122415The Swedish BioFINDER - Memory Clinic Study
This Swedish study is testing whether new blood tests can replace spinal fluid tests for diagnosing memory and dementia conditions. Researchers are comparing…
- Not Alzheimer's focused, genotype irrelevantNCT06191198Communication Bridge 3 Study
This Phase 2 trial is comparing two speech-language therapy approaches for people with mild to moderate Primary Progressive Aphasia, a condition that gradually…
- Open to carriers, genotype-relevant donationNCT06203106NYSCF Scientific Discovery Biobank
This is a biobank study, not a treatment trial. NYSCF is collecting blood, skin, or saliva samples from people with various diseases — including Alzheimer's —…
- Records study, no APOE4 relevanceNCT06209515Sociodemographic Factors and Criminal Behaviour Preceding Neurodegenerative Disease - Retrospective Register Study
This is not a clinical treatment trial. It is a Finnish records-based research study examining whether people later diagnosed with a neurodegenerative disease…
- Not APOE4-focused, PPA patients onlyNCT06211374Communication Bridge Pilot Study
This trial is testing a web-based communication program called Communication Bridge, designed specifically for people with primary progressive aphasia (PPA) —…
- Observational only, genotype not relevantNCT06337578Advances in Telephone-based Cognitive Screening Procedures
This Italian observational study is testing whether cognitive screening done by telephone works as well as standard in-person testing for people with…
- Observational only, genotype not relevantNCT06338397Social & Affective Cognition in Alzheimer's Disease & Associated Disorders
This study is testing a tool called SCANN to measure how well people with Alzheimer's disease or frontotemporal degeneration understand social cues and…
- Admin study, no APOE4 focusNCT06377033Using the EHR to Advance Genomic Medicine Across a Diverse Health System
This trial is testing whether small prompts built into the electronic health record (EHR) — called behavioral nudges — can get more doctors and patients to…
- Observational only, genotype not consideredNCT06528964Proteinopathies Expression in Skin of Neurodegenerative Disorders
This observational study collects small skin biopsies from people who have been diagnosed with Alzheimer's disease, Parkinson's disease, or several related…
- Unrelated to APOE4 or Alzheimer'sNCT06595212Genetics and Environment iNtersection In the ALS-FTD Spectrum: an Italian Twins Cohort studY With a Multi-Omics Approach
This Italian study is recruiting twins where at least one twin has ALS or frontotemporal dementia (FTD). By comparing the affected twin to their unaffected…
- Open to carriers, not 4-specificNCT06596746Neurodegenerative Diseases Progression Markers (MARKERS-NDD)
MARKERS-NDD is an observational study — no drug or treatment involved. Researchers are collecting clinical data, brain scans, blood tests, movement…
- FTD trial, not APOE4-relevantNCT06604520Vortioxetine for the Treatment of Mood and Cognitive Symptoms in Frontotemporal Dementia
This trial is testing whether vortioxetine, an antidepressant already approved for depression, can improve mood symptoms and thinking abilities in people with…
- Device study, genotype not consideredNCT06668610A Multifocal TDCS-EEG Protocol for Improving Symptoms of Mild Cognitive Impairment and Early Dementia
This trial is testing whether a non-invasive brain stimulation technique called multifocal tDCS, combined with cognitive training, can ease thinking and mood…
- Non-drug trial, genotype not consideredNCT06733714Association of Transcranial Alternating Current Stimulation with Digital Cognitive Training for Cognitive Remediation in Older Adults
This trial combines two non-drug approaches — a brain-stimulation device called tACS, which delivers mild electrical currents to the scalp, and a computerized…
- Not APOE4-specific, Italy onlyNCT06739967Speech and Language Interventions for Italian People With PPA
This pilot study is testing tailored speech and language therapy for people in Italy who have primary progressive aphasia, a condition that gradually erodes…
- Non-Alzheimer's trial, genotype not relevantNCT06761729The Ketogenic Diet in the Treatment of Behavioral Variant Frontotemporal Dementia
This trial is testing a specific ketogenic diet formula called JT821 in people diagnosed with behavioral variant frontotemporal dementia, a type of dementia…
- Open to carriers, not 4-specificNCT06768996Music, Social Attention, and Dementia
This study is testing whether rhythmic music activities — drumming or clapping together versus alone — can improve social connection and attention between…
- Genotype not a stated focusNCT06803784Discovery and Validation of Protein Structural Complexes in Circulating Biofluids As Novel Biomarkers for Early Diagnosis, Prognosis and Therapeutic Management of Patients Affected by Neurodegenerative Disorders
This study is collecting blood and other biofluid samples from people with Parkinson's, Alzheimer's, FTD, ALS, and healthy volunteers. The goal is to find new…
- Not relevant to APOE4 carriersNCT06870838Neuroinflammation in FTLD
This observational study is investigating neuroinflammation in frontotemporal lobar degeneration, a group of brain diseases distinct from Alzheimer's.…
- Unrelated to APOE4 or Alzheimer'sNCT06885918ALS Research Collaborative
This is a natural history study — not a drug trial — focused on ALS and related motor neuron diseases. Researchers are collecting biological and clinical data…
- Open to carriers, not 4-specificNCT06978946Deep Cervical Lymphaticovenous Anastomosis Surgery for Moderate-to-Advanced Dementia Patients
This trial is testing a surgical procedure called Deep Cervical Lymphaticovenous Anastomosis, or DLVA, in people aged 50 to 80 with moderate to severe…
- Diagnostic study, genotype not consideredNCT07100470Metabolic Characterization of Alzheimer's Disease and Frontotemporal Dementia by 23Na-MRI and FDG-PET
This study uses two specialized brain scans — a sodium MRI (which measures salt concentrations in brain cells) and an FDG-PET scan (which measures glucose…
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Educational, not medical advice. Trial decisions belong between you and your physician.