NCT04957537 · RECRUITING
Semantic Rehabilitation for Patients With Primary Progressive Semantic Aphasia
This trial is testing a behavioral therapy program designed to help people with semantic primary progressive aphasia — a rare condition that gradually erodes the ability to understand and use word meanings. Researchers are measuring whether structured language and meaning-focused sessions can slow or improve that decline. This is a Phase NA study, meaning it is a small, specialized trial focused on evaluating the therapy approach rather than a large-scale drug test.
You may qualify if
- Have a diagnosis of primary progressive semantic aphasia according to the criteria of Gorno-Tempini et al (2011) (Appendix A)
- Being in the mild to moderate stage of dementia (MMSE score between 10 and 28) (Crum et al., 1993; Derouesné et al., 1999)
- Common French
- Being affiliated to a social security scheme
- Being over the age of 18 years old
You're excluded if
- Have significant uncorrected visual and/or hearing impairment
- Have a history of brain injuries, major head trauma
- Have untreated psychiatric disorders
- Have significant motor and/or comprehension problems that make it impossible to take part in the study
- Chronical use of drugs and/or alcohol
- Under guardians or curators
- Severe depression (Beck's depression scale score > 9) (Beck \& al., 1961)
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-08-11