NCT04881617 · ACTIVE NOT RECRUITING
Treatment for Speech and Language in Primary Progressive Aphasia
This trial is testing two speech-language therapies for people with primary progressive aphasia, a neurological condition that slowly erodes the ability to speak and communicate. One approach trains word-finding skills; the other uses scripted video conversations. Researchers want to know whether either therapy slows the decline in communication ability over time. This is a Phase NA behavioral study, meaning it is evaluating real-world therapeutic techniques rather than a drug.
You may qualify if
- Meets diagnostic criteria for Primary Progressive Aphasia (PPA; Gorno-Tempini et al., 2011)
- Score of 15 or higher on the Mini-Mental State Examination
You're excluded if
- Other neurological or psychiatric diagnosis that may contribute to cognitive-linguistic deficits
- Significant, uncorrected visual or hearing impairment that would interfere with participation
- Score of less than 15 on the Mini-Mental State Examination
- Prominent initial non-speech-language impairment (cognitive, behavioral, motoric)
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-11-13