NCT03147937 · ACTIVE NOT RECRUITING
Cognitive Changes After Major Joint Replacement - Full Trial (Cognigram 2)
This study tracks changes in thinking and memory in people age 50 and older having a hip or knee replacement. Researchers use a computer-based cognitive test before surgery and after discharge. It is an observational study with no drug or treatment given. The phase is not specified, and no approved therapy is being tested.
You may qualify if
- All patients ≥ 50 years of age undergoing elective total hip or knee arthroplasty at Sunnybrook Health Sciences Centre
You're excluded if
- Lack of informed consent
- Inability to comply with study procedures or follow-up visits
- Patients with diagnosed dementia or those being treated with donepezil (Aricept®)
- Patients with severe cognitive impairment defined as baseline with a CBB score of equal to or less than 80 in at least one of the 4 CBB domains
- Patients with uncontrolled psychiatric diagnoses including schizophrenia, bipolar disorder, major depressive mood disorder
- Patients undergoing a second joint replacement \& previously enrolled in this study within the past 6 months
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-09-05