Trials in Missouri.

This trial tested bapineuzumab, an infused antibody designed to bind and clear beta amyloid from the brain, against a placebo. It measured whether it helped…

This trial tested whether bapineuzumab, an antibody given by infusion that helps clear beta amyloid from the brain, could affect thinking and daily function in…

This Phase 2 trial tested lecanemab, an anti-amyloid antibody given by infusion, in people with early Alzheimer's disease — either mild cognitive impairment or…

This trial tested two investigational drugs, CAD106 (a vaccine-like immunotherapy targeting amyloid) and CNP520 (a small molecule targeting amyloid…

This trial tested CNP520, a drug designed to reduce amyloid buildup in the brain, against a placebo in cognitively normal older adults at elevated risk for…

This study uses brain scans to look at how brain connections, blood vessel health, and Alzheimer's-related proteins (amyloid and tau) relate to each other in…

This Phase 3 trial tests lecanemab, an intravenous and subcutaneous antibody drug, against placebo in people with early Alzheimer's disease — either mild…

This Phase 3 trial is testing lecanemab, an anti-amyloid antibody drug, in people who are cognitively normal but have early amyloid buildup in their brains —…

This trial is testing whether sirolimus, an FDA-approved drug used in transplant medicine, can improve blood flow to the brain in cognitively healthy adults.…

This trial is testing whether sirolimus (rapamycin), an FDA-approved drug already used for other conditions, can improve blood flow and brain energy use in…

This trial tested bapineuzumab, an antibody drug given by infusion, against a placebo in people with mild to moderate Alzheimer's. It looked at how well the…

This trial tested bapineuzumab, an antibody drug given by infusion, against a placebo in people with mild to moderate Alzheimer's. Researchers measured safety…

This is an observational study, meaning no drug or treatment is given. Researchers follow families with a rare inherited gene mutation that causes Alzheimer's,…

This trial looked at the long-term safety and tolerability of bapineuzumab, an antibody drug given by infusion, in people with Alzheimer's who had finished an…

This study uses a brain scan called PIB PET, which can show amyloid buildup, to work out what kind of dementia develops in people with Parkinson's disease. The…

This trial tests whether a more precise form of whole-brain radiation can spare the hippocampus, the brain's memory center, in people whose cancer has spread…

Enroll-HD is an observational study, meaning no drug or treatment is given. It follows people with Huntington's disease, and their relatives and controls,…

This trial tests several investigational drugs, including gantenerumab, solanezumab, E2814 and lecanemab, against placebo. It asks whether they slow cognitive…

This Phase 3 trial tested solanezumab, an antibody drug given by IV infusion, in cognitively normal older adults who already had amyloid buildup in their…

This trial tested lanabecestat, a BACE inhibitor drug designed to reduce amyloid production in the brain, against a placebo over two years in people with early…

This study uses a radioactive tracer called flortaucipir (F 18 T807) and PET brain scans to look for tau, a protein that clumps in Alzheimer's. Researchers…

This study uses two kinds of brain scans, called PiB PET and VAT PET, to look at people who have Parkinson disease. The scans measure amyloid plaques and a…

This Phase 3 trial tested whether LCZ696 (sacubitril/valsartan, sold as Entresto) protects cognitive function better than valsartan alone in people with a…

This study is not testing a treatment. It is an observational study tracking how people with early-stage Alzheimer's disease or MCI use health care, what that…

This trial is testing whether CPAP — the device used to treat sleep apnea — can slow the progression of memory problems in people who already have mild…

LEADS is an observational study, not a treatment trial. Researchers are tracking how early-onset Alzheimer's and related conditions progress over time in…

This trial is testing whether Cognitive Behavioral Therapy for Insomnia works better than basic sleep hygiene education for women who have both fibromyalgia…

This study uses brain scans with a tracer called PIB to look for amyloid, a sticky protein that may be linked to Alzheimer's. It focuses on adult children of…

This is not a treatment trial. It is a study building a pool of adults with Down syndrome, ages 25 to 55, who are ready to be recruited into future Alzheimer's…

PREVENTABLE is a large Phase 4 trial testing whether atorvastatin 40 mg — a common cholesterol-lowering statin — can reduce the combined risk of death,…

This is a large North American research registry and natural history study tracking people with frontotemporal lobar degeneration (FTLD) and related conditions…

This Phase 3 trial tested donanemab, an anti-amyloid antibody drug, against placebo in people with early Alzheimer's disease. Researchers measured how well it…

This trial is testing a behavioral strategy-training program designed to help people with Parkinson's disease manage everyday memory problems. Participants are…

This is a blood-collection study, not a drug test. Researchers are measuring neurofilament, a protein that can signal nerve cell damage, in people from…

This trial is testing a new PET imaging tool called [11C]-CS1P1, which is designed to measure neuroinflammation in the brain. Researchers want to see if this…

This study uses brain scans to look at amyloid and tau, two proteins linked to Alzheimer's. Researchers give small amounts of imaging tracers (PiB and…

This trial tests whether suvorexant, an existing prescription sleep medication, can slow the buildup of amyloid-beta, a protein linked to Alzheimer's, in the…

This trial is testing a web-based version of Cognitive Behavioral Therapy for Insomnia, called NiteCAPP, designed specifically for family caregivers of people…

This trial is studying what happens when researchers share a personalized five-year risk estimate for Alzheimer's dementia with healthy older adults who have…

This study collects blood samples and runs memory and thinking tests to look for genes that influence who gets Alzheimer's disease. It focuses on families…

This trial tests donanemab, an anti-amyloid antibody given by infusion, against a placebo in people with no memory or thinking problems but signs of amyloid in…

This observational study is looking at whether excess body fat — especially when combined with metabolic problems like high blood sugar or insulin resistance —…

This trial tests two investigational drugs, E2814 and lecanemab, in people who carry a gene mutation that causes early-onset Alzheimer's. It measures changes…

This trial is comparing two different PET scan tracers — Flortaucipir and MK-6240 — that are used to measure tau tangles in the brain, a hallmark of…

This study is examining how depression, early Alzheimer's-related brain changes, and antidepressant use affect how older adults drive. Researchers will use PET…

This trial tests ACI-24.060, an active vaccine-style treatment meant to prompt the body to make its own antibodies against amyloid, a sticky protein linked to…

This Phase 3 trial is testing remternetug, an anti-amyloid antibody given by IV or injection under the skin, in people with early symptomatic Alzheimer's…

This early study compares three new brain scan tracers that light up tau, a protein that builds up in Alzheimer's. People with Alzheimer's and healthy older…

This trial tests whether a pill called AR1001 can slow memory and thinking decline in people with early Alzheimer's, compared with a placebo. It also checks…

This trial is testing CT1812, an experimental drug, in people with early Alzheimer's disease — either mild cognitive impairment or mild dementia confirmed by…