NCT05446805 · RECRUITING
Depression and Driving
This study is examining how depression, early Alzheimer's-related brain changes, and antidepressant use affect how older adults drive. Researchers will use PET brain scans and spinal fluid tests to look for amyloid and tau proteins — the biological markers tied to Alzheimer's — and then measure real-world driving behavior. The phase is unspecified, meaning this is most likely an observational study, not a treatment trial.
You may qualify if
- Drive on average at least once per week
- Has a valid driver's license
- Willing to complete blood draw
- Willing to complete either lumbar puncture or PET imaging
- 65 years or older
- Speaks English
You're excluded if
- Not willing to complete blood draw and/or one other biomarker
- Less than 65 years of age
- Does not drive a vehicle/ is no longer actively driving
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-06-08