Trials in Maryland.
55 APOE4-relevant Alzheimer’s trials run in Maryland — 32 of them recruiting. Each one translated into plain English, with our read on what it means for an APOE4 carrier.
- APOE4 carriers explicitly welcomedNCT04468659AHEAD 3-45 Study: A Study to Evaluate Efficacy and Safety of Treatment With Lecanemab in Participants With Preclinical Alzheimer's Disease and Elevated Amyloid and Also in Participants With Early Preclinical Alzheimer's Disease and Intermediate Amyloid
This Phase 3 trial is testing lecanemab, an anti-amyloid antibody drug, in people who are cognitively normal but have early amyloid buildup in their brains —…
- Explicitly welcomes APOE4 carriersNCT06043700A Community-Based Screening Program to Identify Participants at High Risk for Amyloid Pathology
This is a screening study, not a treatment trial. Researchers are using blood tests to find people who may have high levels of amyloid protein in the brain — a…
- Enrolled carriers, prior data unfavorableNCT00348309Rosiglitazone (Extended Release Tablets) As Adjunctive Therapy For Subjects With Mild To Moderate Alzheimer's Disease
This trial tested whether rosiglitazone extended release, a diabetes drug, could improve thinking and memory in people already taking donepezil for mild to…
- Amyloid-focused, drug did not succeedNCT02008357Clinical Trial of Solanezumab for Older Individuals Who May be at Risk for Memory Loss
This Phase 3 trial tested solanezumab, an antibody drug given by IV infusion, in cognitively normal older adults who already had amyloid buildup in their…
- Observational only, genotype not requiredNCT02014246Genetic Characterization of Movement Disorders and Dementias
This is a genetic research study, not a treatment trial. Researchers at the National Institute on Aging are collecting blood or saliva samples from people with…
- Unrelated to APOE4 or Alzheimer'sNCT02855476HDClarity: a Multi-site Cerebrospinal Fluid Collection Initiative to Facilitate Therapeutic Development for Huntington's Disease
HDClarity is collecting cerebrospinal fluid and blood samples from people at various stages of Huntington's disease, plus healthy controls, across multiple…
- Heart trial, genotype not relevantNCT02884206Efficacy and Safety of LCZ696 Compared to Valsartan on Cognitive Function in Patients With Chronic Heart Failure and Preserved Ejection Fraction
This Phase 3 trial tested whether LCZ696 (sacubitril/valsartan, sold as Entresto) protects cognitive function better than valsartan alone in people with a…
- Observational only, no treatment involvedNCT02951598A Study of Health Care Use and Costs in Participants With Early Stage Alzheimer's Disease (AD)
This study is not testing a treatment. It is an observational study tracking how people with early-stage Alzheimer's disease or MCI use health care, what that…
- Unrelated to APOE4 or Alzheimer'sNCT03047369The Myelin Disorders Biorepository Project
This is a biorepository project, not a treatment trial. Researchers are collecting medical records and biological samples (like blood or tissue) from people…
- Open to carriers, not 4-specificNCT03108846Escitalopram for Agitation in Alzheimer's Disease
This Phase 3 trial is testing whether escitalopram, a common antidepressant, can safely reduce agitation in people who already have Alzheimer's dementia. Phase…
- Unrelated conditions, not APOE4-relevantNCT03225144Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
This is a screening and natural history study at the NIH, not a treatment trial. Researchers are enrolling people already diagnosed with ALS, frontotemporal…
- Open to carriers, not 4-specificNCT03507257Longitudinal Early-onset Alzheimer's Disease Study Protocol
LEADS is an observational study, not a treatment trial. Researchers are tracking how early-onset Alzheimer's and related conditions progress over time in…
- Open to carriers, genotype not requiredNCT03799991Vestibular Therapy in Alzheimer's Disease
This trial is testing whether vestibular physical therapy — exercises that retrain the inner ear balance system — can reduce falls in people with mild to…
- Diagnosis-specific, genotype not a factorNCT03887481Targeting Language-specific and Executive-control Networks With Transcranial Direct Current Stimulation in Logopenic Variant PPA
This trial tests whether brain stimulation using a weak electrical current (called tDCS) delivered to specific language and memory areas of the brain, combined…
- Open to carriers, genotype not consideredNCT04122001Effects of Electrical Stimulation on Verbal Learning in Typical and Atypical Alzheimer's Disease
This trial is testing whether mild electrical brain stimulation — called tDCS — applied to a specific region of the brain, combined with a word-learning…
- Open to carriers, not 4-specificNCT04123314Psilocybin for Depression in People With Mild Cognitive Impairment or Early Alzheimer's Disease
This early Phase 1 pilot study is testing whether a single supervised dose of psilocybin — the active compound in psychedelic mushrooms — is safe and can ease…
- Open to carriers, not 4-specificNCT04262206Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults
PREVENTABLE is a large Phase 4 trial testing whether atorvastatin 40 mg — a common cholesterol-lowering statin — can reduce the combined risk of death,…
- FTLD-focused, not APOE4-relevantNCT04363684ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)
This is a large North American research registry and natural history study tracking people with frontotemporal lobar degeneration (FTLD) and related conditions…
- Open to carriers, not 4-specificNCT04396873PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease
This trial uses specialized PET imaging to measure brain inflammation in people with Alzheimer's disease, Parkinson's, ALS, MCI, and related conditions.…
- Explicitly recruits APOE4 carriersNCT04601038Trial of CORT108297 to Attenuate the Effects of Acute Stress in the Allocortex (CORT-X)
This Phase 2 trial tests whether a drug called CORT108297 — which blocks a stress hormone receptor — can protect memory and thinking skills when the brain is…
- Open to carriers, not 4-specificNCT04765137Evaluate the Effect of Atorvastatin on Cerebrovascular Reactivity in Mild Cognitive Impairment (MCI)
This Phase 2 trial is testing whether atorvastatin, a common cholesterol-lowering drug, can improve how well blood vessels in the brain respond and regulate…
- Observational only, genotype not specifiedNCT04916210Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY
The DISCOVERY study is an observational study — no drug or treatment is being tested. Researchers are following stroke survivors over time, collecting…
- Unrelated to APOE4 genotypeNCT05072483Natural History Study of CADASIL
This is a long-term observational study — not a treatment trial — tracking how CADASIL, a rare inherited small-vessel disease of the brain, changes blood…
- Open to carriers, genotype not trackedNCT05151562Music Therapy for Patients With Alzheimer's Disease
This trial is testing whether personalized virtual music therapy sessions, built around songs tied to a person's memories, can improve mood, memory, and…
- Open to carriers, not 4-specificNCT05282550Targeting Cognition in Early Alzheimer's Disease by Improving Sleep With Trazodone
This trial is testing whether low-dose trazodone, a medication already used for sleep, can improve sleep quality and memory in people with amnestic mild…
- Not APOE4-related, PPA patients onlyNCT05386394Transcranial Direct Current Stimulation in the Treatment of Primary Progressive Aphasia
This trial is testing whether transcranial direct current stimulation (tDCS) — a mild electrical current applied to the scalp — combined with language therapy…
- Open to carriers, not 4-specificNCT05531656A Study to Evaluate the Safety and Efficacy of CT1812 in Early Alzheimer's Disease
This trial is testing CT1812, an experimental drug, in people with early Alzheimer's disease — either mild cognitive impairment or mild dementia confirmed by…
- Closed follow-up, genotype not a factorNCT05532657ACHIEVE Brain Health Follow-Up Study
This trial is a 3-year follow-up to a completed study called ACHIEVE. It is tracking whether older adults who received hearing aids earlier show less cognitive…
- Observational stroke study, genotype not requiredNCT05556395Global Blood-Brain Barrier Disruption and Post-Stroke Cognitive Decline
This study is trying to understand why some stroke survivors develop cognitive decline afterward. Researchers will measure blood-brain barrier disruption —…
- Late-stage dementia care, genotype not relevantNCT05644262Life's End Benefits of cannaBidiol and tetrahYdrocannabinol
This Phase 2 trial is testing whether a liquid oral combination of THC and CBD (the two main active compounds in cannabis) can reduce agitation in people with…
- Not relevant to APOE4 or Alzheimer'sNCT05686551GENERATION HD2. A Study to Evaluate the Safety, Biomarkers, and Efficacy of Tominersen Compared With Placebo in Participants With Prodromal and Early Manifest Huntington's Disease
This trial is testing tominersen, a drug injected into the spinal fluid, against a placebo in people with prodromal or early Huntington's Disease. The goal is…
- Vascular focus, genotype not mentionedNCT05703386Imaging the Pathogenesis of Cerebral Small Vessel Disease
This study is not testing a treatment. It is an observational study that uses repeated MRI scans to watch how white matter damage in the brain develops over…
- Likely directly relevant to APOE4 carriersNCT05795634Cognitive Vulnerability to Stress in Individuals at Risk for Alzheimer's Disease
This study is testing whether stress hormones and genes linked to Alzheimer's risk predict how much a brief social stress experience affects memory and…
- Not relevant to APOE4 carriersNCT05858996Testing the Pain Clinical Practice Guideline
This trial is testing a structured pain management program for nursing home residents who have dementia. Half of the participating homes will get the full…
- Open to carriers, genotype not requiredNCT05948930Working Memory and Physical Exercise Training in Patients With Mild Cognitive Impairment
This trial is testing whether combining aerobic exercise with computerized brain training improves memory and brain function in people with mild cognitive…
- Unrelated to APOE4 or Alzheimer'sNCT05956834A Multi-Modal Remote Monitoring Platform for Frontotemporal Lobar Degeneration (FTLD) Syndromes
This observational study is tracking motor symptoms in people diagnosed with Progressive Supranuclear Palsy (PSP) using two wearable sensor devices — PAMSys…
- ARIA risk — carriers discuss carefullyNCT06058234Medicare Anti-Aβ mAb Coverage With Evidence Development (CED) Study
This is not a typical drug experiment. It is a Medicare-required data collection study tracking real-world outcomes for patients already receiving FDA-approved…
- Unrelated to APOE4 or dementiaNCT06516965A Study to Evaluate the Efficacy and Safety Study of Povorcitinib in Participants With Prurigo Nodularis (STOP-PN2)
This Phase 3 trial is testing povorcitinib, a JAK inhibitor pill, against a placebo in people with prurigo nodularis — a chronic skin condition causing intense…
- FTD trial, not APOE4-relevantNCT06604520Vortioxetine for the Treatment of Mood and Cognitive Symptoms in Frontotemporal Dementia
This trial is testing whether vortioxetine, an antidepressant already approved for depression, can improve mood symptoms and thinking abilities in people with…
- Unrelated to APOE4 or Alzheimer'sNCT06667414Frequency of Selected Single Nucleotide Polymorphisms in Huntington Disease Gene Expansion Carriers
This study is mapping specific genetic markers called SNPs in people who carry the Huntington's disease gene mutation. Participants give a blood sample and…
- Open to carriers, not 4-specificNCT06721156A Study to Evaluate the Efficacy and Safety of MK-1167 in Participants With Alzheimer's Disease Dementia (MK-1167-008)
This trial is testing MK-1167, an experimental drug given alongside a standard Alzheimer's medication called an acetylcholinesterase inhibitor. Researchers…
- Open to carriers, not 4-specificNCT06847321Study of LHP588 in Subjects With P. Gingivalis-Positive Alzheimer's Disease
This Phase 2 trial is testing LHP588, an oral capsule taken once daily, in people with mild to moderate Alzheimer's disease who also test positive for P.…
- Open to carriers, not 4-specificNCT06930560HEARS-NPS: Addressing Hearing Loss as a Common Unmet Contributor of Neuropsychiatric Symptoms
This trial is testing a hearing care program for people who already have Alzheimer's disease or a related dementia and also have untreated hearing loss. The…
- Symptom trial, genotype not addressedNCT06937229A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease (ADAGIO-3)
This Phase 3 trial is testing two drug formulations — KarXT and KarX-EC, both containing the same active ingredient xanomeline — for long-term management of…
- Open to carriers, not 4-specificNCT07011732A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease (ADAGIO-1)
This trial is testing two drug combinations — KarXT (xanomeline plus trospium) and KarX-EC — to see whether they reduce agitation in people with confirmed…
- Not relevant to APOE4 carriersNCT07061470A Clinical Trial of Iron Supplementation for Youth With ADHD and Restless Sleep
This trial is testing whether a daily iron supplement (ferrous sulfate, available over the counter) reduces restless sleep and eases ADHD symptoms in children…
- Observational only, genotype not requiredNCT07099053Amyloid PET Imaging in the Baltimore Longitudinal Study of Aging
This observational study is tracking amyloid protein buildup in the brains of adults 55 and older using PET-CT scans, repeated every one to four years.…
- Open to carriers, not 4-specificNCT07169630PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairment (MCI)
This trial is testing a new PET scan radiotracer called 18F-PF974 to see if it can measure an enzyme called PDE4B in the brains of people with Alzheimer's…
- Unrelated to APOE4 entirelyNCT07204977Acamprosate in C9orf72 Hexanucleotide Repeat Expansion Amyotrophic Lateral Sclerosis (ACALS)
This trial is testing acamprosate — a pill already approved for alcohol dependence — in people who have ALS caused by a specific genetic mutation called…
- Not Alzheimer's, APOE4 irrelevantNCT07240805Digital Health Technologies for Progressive Supranuclear Palsy and Dementia With Lewy Bodies
This study is testing wearable sensor devices to track movement and physical function in people already diagnosed with Progressive Supranuclear Palsy, MCI with…
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Educational, not medical advice. Trial decisions belong between you and your physician.