Trials in Maryland.
80 APOE4-relevant Alzheimer’s trials run in Maryland — 43 of them recruiting. Each one translated into plain English, with our read on what it means for an APOE4 carrier.
- Non-carriers only, not for APOE4NCT00574132Bapineuzumab in Patients With Mild to Moderate Alzheimer's Disease (ApoE4 Non-Carrier)
This trial tested bapineuzumab, an infused antibody designed to bind and clear beta amyloid from the brain, against a placebo. It measured whether it helped…
- Drug trial for diagnosed APOE4 carriersNCT00575055Bapineuzumab in Patients With Mild to Moderate Alzheimer's Disease (ApoE4 Carrier)
This trial tested whether bapineuzumab, an antibody given by infusion that helps clear beta amyloid from the brain, could affect thinking and daily function in…
- APOE4 carriers explicitly welcomedNCT04468659AHEAD 3-45 Study: A Study to Evaluate Efficacy and Safety of Treatment With Lecanemab in Participants With Preclinical Alzheimer's Disease and Elevated Amyloid and Also in Participants With Early Preclinical Alzheimer's Disease and Intermediate Amyloid
This Phase 3 trial is testing lecanemab, an anti-amyloid antibody drug, in people who are cognitively normal but have early amyloid buildup in their brains —…
- Drug trial — APOE4 carriers excludedNCT05986721Clinical Trial of AGB101 for Mild Cognitive Impairment
This trial tests AGB101, a once-daily pill (220 mg), against a placebo for 78 weeks in people with mild cognitive impairment likely due to Alzheimer's.…
- Explicitly welcomes APOE4 carriersNCT06043700A Community-Based Screening Program to Identify Participants at High Risk for Amyloid Pathology
This is a screening study, not a treatment trial. Researchers are using blood tests to find people who may have high levels of amyloid protein in the brain — a…
- Enrolled carriers, prior data unfavorableNCT00348309Rosiglitazone (Extended Release Tablets) As Adjunctive Therapy For Subjects With Mild To Moderate Alzheimer's Disease
This trial tested whether rosiglitazone extended release, a diabetes drug, could improve thinking and memory in people already taking donepezil for mild to…
- Drug trial, genotype not specified in sourceNCT00667810Study Evaluating The Efficacy And Safety Of Bapineuzumab In Alzheimer Disease Patients
This trial tested bapineuzumab, an antibody drug given by infusion, against a placebo in people with mild to moderate Alzheimer's. It looked at how well the…
- Cancer trial, not for healthy carriersNCT01227954Avoiding the Hippocampus During Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases
This trial tests whether a more precise form of whole-brain radiation can spare the hippocampus, the brain's memory center, in people whose cancer has spread…
- Huntington's study, not about APOE4NCT01574053Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort
Enroll-HD is an observational study, meaning no drug or treatment is given. It follows people with Huntington's disease, and their relatives and controls,…
- Amyloid-focused, drug did not succeedNCT02008357Clinical Trial of Solanezumab for Older Individuals Who May be at Risk for Memory Loss
This Phase 3 trial tested solanezumab, an antibody drug given by IV infusion, in cognitively normal older adults who already had amyloid buildup in their…
- Observational only, genotype not requiredNCT02014246Genetic Characterization of Movement Disorders and Dementias
This is a genetic research study, not a treatment trial. Researchers at the National Institute on Aging are collecting blood or saliva samples from people with…
- Unrelated to APOE4 or Alzheimer'sNCT02855476HDClarity: a Multi-site Cerebrospinal Fluid Collection Initiative to Facilitate Therapeutic Development for Huntington's Disease
HDClarity is collecting cerebrospinal fluid and blood samples from people at various stages of Huntington's disease, plus healthy controls, across multiple…
- Heart trial, genotype not relevantNCT02884206Efficacy and Safety of LCZ696 Compared to Valsartan on Cognitive Function in Patients With Chronic Heart Failure and Preserved Ejection Fraction
This Phase 3 trial tested whether LCZ696 (sacubitril/valsartan, sold as Entresto) protects cognitive function better than valsartan alone in people with a…
- Observational only, no treatment involvedNCT02951598A Study of Health Care Use and Costs in Participants With Early Stage Alzheimer's Disease (AD)
This study is not testing a treatment. It is an observational study tracking how people with early-stage Alzheimer's disease or MCI use health care, what that…
- Unrelated to APOE4 or Alzheimer'sNCT03047369The Myelin Disorders Biorepository Project
This is a biorepository project, not a treatment trial. Researchers are collecting medical records and biological samples (like blood or tissue) from people…
- Open to carriers, not 4-specificNCT03108846Escitalopram for Agitation in Alzheimer's Disease
This Phase 3 trial is testing whether escitalopram, a common antidepressant, can safely reduce agitation in people who already have Alzheimer's dementia. Phase…
- Unrelated conditions, not APOE4-relevantNCT03225144Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
This is a screening and natural history study at the NIH, not a treatment trial. Researchers are enrolling people already diagnosed with ALS, frontotemporal…
- Open to carriers, not 4-specificNCT03507257Longitudinal Early-onset Alzheimer's Disease Study Protocol
LEADS is an observational study, not a treatment trial. Researchers are tracking how early-onset Alzheimer's and related conditions progress over time in…
- Open to carriers, genotype not requiredNCT03799991Vestibular Therapy in Alzheimer's Disease
This trial is testing whether vestibular physical therapy — exercises that retrain the inner ear balance system — can reduce falls in people with mild to…
- Diagnosis-specific, genotype not a factorNCT03887481Targeting Language-specific and Executive-control Networks With Transcranial Direct Current Stimulation in Logopenic Variant PPA
This trial tests whether brain stimulation using a weak electrical current (called tDCS) delivered to specific language and memory areas of the brain, combined…
- Huntington's trial, not relevant to APOE4NCT04120493Safety and Proof-of-Concept (POC) Study With AMT-130 in Adults With Early Manifest Huntington's Disease
This trial tests AMT-130, a gene therapy delivered by brain surgery into a deep brain region called the striatum, in adults with early Huntington's disease. It…
- Open to carriers, genotype not consideredNCT04122001Effects of Electrical Stimulation on Verbal Learning in Typical and Atypical Alzheimer's Disease
This trial is testing whether mild electrical brain stimulation — called tDCS — applied to a specific region of the brain, combined with a word-learning…
- Open to carriers, not 4-specificNCT04123314Psilocybin for Depression in People With Mild Cognitive Impairment or Early Alzheimer's Disease
This early Phase 1 pilot study is testing whether a single supervised dose of psilocybin — the active compound in psychedelic mushrooms — is safe and can ease…
- Open to carriers, not 4-specificNCT04262206Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults
PREVENTABLE is a large Phase 4 trial testing whether atorvastatin 40 mg — a common cholesterol-lowering statin — can reduce the combined risk of death,…
- FTLD-focused, not APOE4-relevantNCT04363684ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)
This is a large North American research registry and natural history study tracking people with frontotemporal lobar degeneration (FTLD) and related conditions…
- Open to carriers, not 4-specificNCT04396873PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease
This trial uses specialized PET imaging to measure brain inflammation in people with Alzheimer's disease, Parkinson's, ALS, MCI, and related conditions.…
- Not APOE4-related; FTD gene families onlyNCT04516499Neurofilament Surveillance Project (NSP)
This is a blood-collection study, not a drug test. Researchers are measuring neurofilament, a protein that can signal nerve cell damage, in people from…
- Explicitly recruits APOE4 carriersNCT04601038Trial of CORT108297 to Attenuate the Effects of Acute Stress in the Allocortex (CORT-X)
This Phase 2 trial tests whether a drug called CORT108297 — which blocks a stress hormone receptor — can protect memory and thinking skills when the brain is…
- Not Alzheimer's-focused, genotype not mentionedNCT04753320Remote Monitoring in Progressive Supranuclear Palsy (PSP)
This study tests no drug. It watches how wearable sensors and remote digital tools track falls, movement, speech, and thinking in people with progressive…
- Open to carriers, not 4-specificNCT04765137Evaluate the Effect of Atorvastatin on Cerebrovascular Reactivity in Mild Cognitive Impairment (MCI)
This Phase 2 trial is testing whether atorvastatin, a common cholesterol-lowering drug, can improve how well blood vessels in the brain respond and regulate…
- Observational only, genotype not specifiedNCT04916210Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY
The DISCOVERY study is an observational study — no drug or treatment is being tested. Researchers are following stroke survivors over time, collecting…
- Drug trial, genotype not specified, ARIA riskNCT05026866A Donanemab (LY3002813) Study in Participants With Preclinical Alzheimer's Disease (TRAILBLAZER-ALZ 3)
This trial tests donanemab, an anti-amyloid antibody given by infusion, against a placebo in people with no memory or thinking problems but signs of amyloid in…
- Unrelated to APOE4 genotypeNCT05072483Natural History Study of CADASIL
This is a long-term observational study — not a treatment trial — tracking how CADASIL, a rare inherited small-vessel disease of the brain, changes blood…
- Open to carriers, genotype not trackedNCT05151562Music Therapy for Patients With Alzheimer's Disease
This trial is testing whether personalized virtual music therapy sessions, built around songs tied to a person's memories, can improve mood, memory, and…
- Not APOE4-related; FTD-GRN drug trialNCT05262023A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DNL593 in Healthy Participants and Participants With Frontotemporal Dementia (FTD-GRN)
This study is testing DNL593, an experimental drug, against a placebo. It looks at safety, how the body processes the drug, and its effects on the body. It…
- Open to carriers, not 4-specificNCT05282550Targeting Cognition in Early Alzheimer's Disease by Improving Sleep With Trazodone
This trial is testing whether low-dose trazodone, a medication already used for sleep, can improve sleep quality and memory in people with amnestic mild…
- Not APOE4-related, PPA patients onlyNCT05386394Transcranial Direct Current Stimulation in the Treatment of Primary Progressive Aphasia
This trial is testing whether transcranial direct current stimulation (tDCS) — a mild electrical current applied to the scalp — combined with language therapy…
- Open to carriers, not 4-specificNCT05531656A Study to Evaluate the Safety and Efficacy of CT1812 in Early Alzheimer's Disease
This trial is testing CT1812, an experimental drug, in people with early Alzheimer's disease — either mild cognitive impairment or mild dementia confirmed by…
- Closed follow-up, genotype not a factorNCT05532657ACHIEVE Brain Health Follow-Up Study
This trial is a 3-year follow-up to a completed study called ACHIEVE. It is tracking whether older adults who received hearing aids earlier show less cognitive…
- Symptom drug trial, not APOE4-specificNCT05543681Clinical Trial on Agitation in Alzheimer's Dementia
This trial tests whether IGC-AD1, a twice-daily oral THC-based medication, can ease agitation in people with mild to severe Alzheimer's dementia. Agitation…
- Observational stroke study, genotype not requiredNCT05556395Global Blood-Brain Barrier Disruption and Post-Stroke Cognitive Decline
This study is trying to understand why some stroke survivors develop cognitive decline afterward. Researchers will measure blood-brain barrier disruption —…
- Late-stage dementia care, genotype not relevantNCT05644262Life's End Benefits of cannaBidiol and tetrahYdrocannabinol
This Phase 2 trial is testing whether a liquid oral combination of THC and CBD (the two main active compounds in cannabis) can reduce agitation in people with…
- Veterans only, not APOE4-specificNCT05663034CBT-I vs. MBTI for Traumatic Brain Injury (TBI)-Related Insomnia and Post-Traumatic Stress Symptoms
This trial compares two talk-based therapies for insomnia in military veterans and service members with a past traumatic brain injury and trauma-related stress…
- Not relevant to APOE4 or Alzheimer'sNCT05686551GENERATION HD2. A Study to Evaluate the Safety, Biomarkers, and Efficacy of Tominersen Compared With Placebo in Participants With Prodromal and Early Manifest Huntington's Disease
This trial is testing tominersen, a drug injected into the spinal fluid, against a placebo in people with prodromal or early Huntington's Disease. The goal is…
- Vascular focus, genotype not mentionedNCT05703386Imaging the Pathogenesis of Cerebral Small Vessel Disease
This study is not testing a treatment. It is an observational study that uses repeated MRI scans to watch how white matter damage in the brain develops over…
- Likely directly relevant to APOE4 carriersNCT05795634Cognitive Vulnerability to Stress in Individuals at Risk for Alzheimer's Disease
This study is testing whether stress hormones and genes linked to Alzheimer's risk predict how much a brief social stress experience affects memory and…
- Not relevant to APOE4 carriersNCT05858996Testing the Pain Clinical Practice Guideline
This trial is testing a structured pain management program for nursing home residents who have dementia. Half of the participating homes will get the full…
- Open to carriers, genotype not requiredNCT05948930Working Memory and Physical Exercise Training in Patients With Mild Cognitive Impairment
This trial is testing whether combining aerobic exercise with computerized brain training improves memory and brain function in people with mild cognitive…
- Unrelated to APOE4 or Alzheimer'sNCT05956834A Multi-Modal Remote Monitoring Platform for Frontotemporal Lobar Degeneration (FTLD) Syndromes
This observational study is tracking motor symptoms in people diagnosed with Progressive Supranuclear Palsy (PSP) using two wearable sensor devices — PAMSys…
- Military TBI study, not APOE4-specificNCT06034509Cognitive and Vascular Functioning Following TBI
This is an observational study, so nothing is being given or changed. Researchers will look at blood markers, brain scans, and clinical data in service members…
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Educational, not medical advice. Trial decisions belong between you and your physician.