NCT05556395 · RECRUITING
Global Blood-Brain Barrier Disruption and Post-Stroke Cognitive Decline
This study is trying to understand why some stroke survivors develop cognitive decline afterward. Researchers will measure blood-brain barrier disruption — essentially leakiness in the protective lining around the brain — at the time of stroke, then track thinking and memory over the next three years to see if that early measurement predicts who declines. This is an observational study, meaning no treatment is being tested.
Inclusion criteria
- Acute ischemic stroke demonstrated on an MRI scan that includes perfusion imaging with an exogenous contrast agent
Exclusion criteria
- Inability to perform telephone-based cognitive assessments
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-09-29